Wait, What Do You Do?

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner? About Pioneering Medicines: Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship’s innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship’s bioplatform companies. Within Flagship’s Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners’ R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary: Reporting to the CSO, this position serves as a member of the Drug Discovery leadership team and will work collaboratively with all other Functions in Pioneering Medicines (PM), as well as with other Flagship Pioneering companies (FSP). This individual will oversee Discovery biology and pharmacology activities within the company, a world-class organization dedicated to the discovery and advancement of novel therapeutic approaches across different disease areas. The ideal candidate will have experience in target identification/validation, drug discovery, and preclinical translational research. This individual will play and serve as a critical interface between Discovery Biology/Translational Sciences and Clinical Development leadership to support a portfolio with several preclinical and clinical programs. Responsibilities: <ul> <li>Work with CSO and other company leaders to develop and implement Research Strategy</li> <li>Lead a department of cell biologists, pharmacologists for the discovery of new therapeutics in autoimmune, oncology, cardiovascular and metabolic space.</li> <li>Lead the investigation of disease biology and identification/validation of new drug targets and execute efficient preclinical lead optimization and translational biology, incorporating target engagement and functional biomarkers of drug action.</li> <li>Work across FSP to identify targets, platforms, or other areas of collaboration.</li> <li>Ensure scientific rigor across a robust portfolio of both early and late-stage discovery programs and exploratory research in emerging areas of autoimmunity and cancer</li> <li>Oversee strategic and tactical execution of discovery research and preclinical activities to enable robust, timely and compliant IND submissions with clear development paths</li> <li>Lead and recruit at the highest scientific caliber and maintain an effective network of outside partners, KOLs, collaborators and service organizations</li> <li>Lead partnerships with external collaborators to deliver company research priorities and meaningfully contribute to the product portfolio</li> <li>Participate in the identification and evaluation of potential programs across the FSP landscape.</li> </ul> Required Experience: <ul> <li>PhD in Cell Biology or related field with broad expertise in autoimmunity, metabolic disease and/or inflammation research.</li> <li>A minimum of 10 years of scientific experience after the doctoral degree and a distinguished record of progressive leadership in a relevant scientific organization(s)</li> <li>Solid background in drug discovery is required</li> <li>Expertise in multiple modalities such as small molecules, large molecules, gene therapies and cell therapies</li> <li>Experience leading projects and teams in pre-clinical pharmacology, inflammation and/or translational research</li> <li>Extensive publication record in first-tier journals and a knowledge-base that can contribute to an innovation-centric research organization</li> <li>Outstanding management expertise with strong administrative skills and experience in planning, scheduling, and execution of multiple programs and projects, strategic planning in a dynamic and cutting-edge research environment</li> <li>A demonstrated track record of being an effective collaborator</li> <li>The ability to recruit, train, and inspire a high-performing team that is prepared to meet the ongoing challenges and opportunities of a rapidly growing and ambitious organization</li> </ul> About Flagship  Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.    What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet.  Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies.  At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.  Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. <div class="content-conclusion"> </div> <div class="content-conclusion">   Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.  </div> The salary range for this role is $252,000 - $410,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.<div class="content-conclusion">  Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com. </div>

Pioneering Medicines: Vice President / Senior Vice President