Senior Data Scientist, Science

<h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">The Team</span></h2> <p><span style="font-family: helvetica, arial, sans-serif;">CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease.&nbsp;</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems — paving the way for new discoveries that will change medicine in the decades that follow:</span></p> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Building an AI-based virtual cell model to predict and understand cellular behavior</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Developing state-of-the-art imaging systems to observe living cells in action</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Instrumenting tissues to better understand inflammation, a key driver of many diseases</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Engineering and harnessing the immune system for early detection, prevention, and treatment of disease</span></li> </ul> <p><span style="font-family: helvetica, arial, sans-serif;">CZI’s <a href="http://www.chanzuckerberg.com/science">work in science</a> includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural &amp; Artificial Intelligence at Harvard University. Join us in accelerating science.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">As a Senior Data Scientist, you'll lead the creation of groundbreaking datasets that power our AI/ML efforts within and across our scientific grand challenges. Working at the intersection of data science, biology, and AI, your work will focus on creating large, AI-ready datasets, spanning single-cell sequencing, immune receptor profiling, and mass spectrometry peptidomics data. You will define data needs, format standards, analysis approaches and quality metrics and build pipelines to ingest, transform, and validate data products that form the foundation of our experiments.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;"><strong>Our Data Ecosystem:</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif;">These efforts will form a part of, and interoperate with CZI's larger data ecosystem. We are generating unprecedented scientific datasets that drive biological innovation:</span></p> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Billions of standardized cells of single-cell transcriptomic data, with a focus on&nbsp; measuring genetic and environmental perturbations</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">10s of thousands of donor-matched DNA &amp; RNA samples</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">10s PBs-scale static and dynamic imaging datasets</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">100s TBs-scale mass spectrometry datasets</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Diverse, large multi-modal biological datasets that enable biological bridges across measurement types and facilitate multi-modal model training to define how cells act.</span></li> </ul> <p><span style="font-family: helvetica, arial, sans-serif;">When analysis of a dataset is complete, you will help publish it through public resources like CELLxGENE Discover, the CryoET Portal, and the Virtual Cell Platform, used by tens of thousands of scientists monthly to advance understanding of genetic variants, disease risk, drug toxicities, and therapeutic discovery.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;"><strong>Your Impact</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif;">You'll collaborate with cross-functional teams to lead dataset definition, ingestion, transformation, and delivery for AI modeling and experimental analysis. Success means delivering high-quality, usable datasets that directly address modeling challenges and accelerate scientific progress. Join us in building the data foundation that will transform our understanding of human biology and move us along the path to curing, preventing, and managing all disease.</span></p> <h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">What You'll Do</span></h2> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Contribute the tools required for a robust data ecosystem: build single cell data ingestion pipelines, select data formats, standards, and database schemas, and write validation tools, QC approaches, and analysis pipelines.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Collaborate with Platform Scientists, ML engineers, AI Researchers, and Data Engineers to iteratively evaluate, refine and grow datasets to improve our biological understanding of inflammation.&nbsp;</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Work closely with Platform Scientists to identify technical variables and devise&nbsp; approaches to harmonize data across generation sites to enable joint analysis.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Discover and define new data generation opportunities, and manage the delivery of those data products to our scientific teams.</span></li> </ul> <h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">What You'll Bring</span></h2> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">10+ years of experience with large scale high throughput biological&nbsp; data (single cell sequencing, immune receptor profiling, mass spectrometry).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Demonstrated ability to deliver multiple large biological data products.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience with big data: extraction, transport, loading, databases, standardization, validation, QC, and analysis.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience with processing and orchestration pipelines, such as <a href="https://argoproj.github.io/workflows/">Argo Workflows</a>, <a href="https://www.databricks.com/?itm_data=dwh-glossary">Databricks</a></span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Strong fundamentals in statistical reasoning and machine learning.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience with biological data analysis and QC best practices</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Excellent written and verbal communication skills.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Enthusiasm to ramp up on technologies and learn new domains.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience working in a multidisciplinary environment (scientific platforms, engineering, product, AI Research).</span></li> </ul> <h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">Compensation</span></h2> <p><span style="font-family: helvetica, arial, sans-serif;">The Redwood City, CA base pay range for this role is $190,000 - $261,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.&nbsp;</span></p> <h2><span style="color: rgb(40, 40, 39); font-family: helvetica, arial, sans-serif;">Work Mode</span></h2> <p><span style="font-family: helvetica, arial, sans-serif;">As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.</span></p> <h2><span style="color: rgb(223, 22, 33); font-family: helvetica, arial, sans-serif;"><span style="color: rgb(40, 40, 39);"><strong>Benefits for the Whole You</strong></span>&nbsp;</span></h2> <p><span style="font-family: helvetica, arial, sans-serif;">We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.&nbsp;</span></p> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">CZI provides a generous employer match on employee 401(k) contributions to support planning for the future.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Paid time off to volunteer at an organization of your choice.&nbsp;</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Funding for select family-forming benefits.&nbsp;</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Relocation support for employees who need assistance moving to the Bay Area</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;"><a href="https://chanzuckerberg.com/careers/#benefits"><span style="text-decoration: underline; color: rgb(222, 31, 38);">And more</span></a>!</span></li> </ul> <p><span style="font-family: helvetica, arial, sans-serif;">If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">Explore our&nbsp;<a href="https://chanzuckerberg.com/careers/working-reimagined/"><span style="text-decoration: underline; color: rgb(222, 31, 38);">work modes</span></a>,&nbsp;<a href="https://chanzuckerberg.com/careers/#benefits"><span style="text-decoration: underline; color: rgb(222, 31, 38);">benefits</span></a>, and&nbsp;<span style="text-decoration: underline; color: rgb(222, 31, 38);"><a style="color: rgb(222, 31, 38); text-decoration: underline;" href="https://chanzuckerberg.com/careers/candidate-journey/">interview process</a></span>&nbsp;at&nbsp;<a href="https://www.chanzuckerberg.com/careers"><span style="color: rgb(222, 31, 38);">www.chanzuckerberg.com/careers</span></a>.</span></p> <p><span style="font-weight: 400; color: #7e8c8d;">#LI-Hybrid&nbsp;</span></p><div class="content-conclusion"><table style="width: 100%; height: 60px; margin-left: auto; margin-right: auto;"> <tbody> <tr> <td style="width: 10%;"><span style="color: #000000;">&nbsp;</span></td> <td style="width: 10%;"><span style="color: #000000;">&nbsp;</span></td> <td class="" style="width: 10%;" width="30"><span style="color: #000000;"><a style="color: #000000;" href="https://www.facebook.com/chanzuckerberginitiative/" target="_blank"> <img style="display: block; margin-left: auto; margin-right: auto; max-width: 100%;" src="https://chanzuckerberg.com/wp-content/themes/czi/img/facebook-red.svg" alt="Facebook" border="0"></a></span></td> <td class="" style="width: 10%;" width="30"><span style="color: #000000;"><a style="color: #000000;" href="https://www.instagram.com/chanzuckerberginitiative/" target="_blank"><img style="display: block; margin-left: auto; margin-right: auto; max-width: 100%;" src="https://chanzuckerberg.com/wp-content/themes/czi/img/instagram-red.svg" alt="Instagram" border="0"></a></span></td> <td class="" style="width: 10%;" width="30"><span style="color: #000000;"><a style="color: #000000;" href="https://www.threads.net/@chanzuckerberginitiative/" target="_blank"><img style="display: block; 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