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&lt;p&gt;Montai Health is a privately held, early-stage biotechnology company within the Flagship Pioneering Portfolio founded in 2019. Montai Health’s mission is to improve health outcomes for as many people as possible by unlocking the power of natural bioactives to more rapidly develop safe and efficacious therapies to treat and preempt disease. We do that through our CONECTA™ platform which comprehensively maps Anthromolecule bioactivity across pathways that drive disease. The CONECTA platform leverages rapid and ever-growing advancements in the digitization of natural chemistry and human biology coupled with powerful computational tools for linking chemical structure and bioactivity. This confluence of biotechnologies enables Montai to build a powerful, one-of-a-kind discovery platform focused on creating safe, effective, and more human-centric medicines than ever before.&lt;/p&gt;
&lt;p&gt;We know that pioneering is an expedition.&amp;nbsp; Our values reflect our mission and our culture:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Human driven pioneering&lt;/li&gt;
&lt;li&gt;Relentless hunger for impact&lt;/li&gt;
&lt;li&gt;Interdependently ambitious&lt;/li&gt;
&lt;li&gt;Inclusive courage&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Please join us on our expedition! For more information, please visit &lt;a href=&quot;http://www.montai.com&quot;&gt;www.montai.com&lt;/a&gt;.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for an experienced Head of Systems Biology and Data Science to lead our systems biology and platform data strategy and drive external data access and collaborations. This role will serve as a thought leader driving the computational strategy and systems biology development for our exciting platform reporting to the CTO.&lt;/p&gt;
&lt;p&gt;The successful candidate will be results-driven executive with a proven track record in managing and driving project success as a computational leader in the pharma/biotech industry, preferably with small molecule programs. Furthermore, the successful candidate will have excellent communication and collaboration skills, knowledge of computational and systems biology, data strategy, and experience managing internal and external teams.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Responsibilities&lt;/u&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop our data strategy to acquire or create new data sources, as well as tools for simulation, visualization, and integration with our biology team, ensuring data flows and compliance with applicable regulations.&lt;/li&gt;
&lt;li&gt;Identify and establish partnerships with external partners and vendors to obtain critical data to support target identification, compound discovery, and drug development.&lt;/li&gt;
&lt;li&gt;Serve as a thought leader and strategy lead on computational and systems biology in the development of the platform and partner on advancing our pipeline&lt;/li&gt;
&lt;li&gt;Lead the development and implementation of systems biology, translational bioinformatics, and data science approaches to address discovery, early development and clinical development needs across therapeutic areas – including disease pathway ranking, patient subtyping and biomarker identification.&lt;/li&gt;
&lt;li&gt;Lead the continued identification and exploration of molecules with a history of human consumption to build our Anthrographs™&lt;/li&gt;
&lt;li&gt;Grow and lead a team of skilled bioinformatic and computational scientists, data scientists and engineers&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Required Qualifications: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;8+ Years of Data Science or Systems Biology experience in Pharma, PhD in computational biology, statistical genetics, systems biology, or related field.&lt;/li&gt;
&lt;li&gt;Strong track record of developing therapeutics using a systems biology approach focused on pathways in either the discovery or development process&lt;/li&gt;
&lt;li&gt;Experience working with or building platforms for target or therapeutic discovery&lt;/li&gt;
&lt;li&gt;Track record of leading and managing data partnerships with vendors or partners&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;5+ years of direct supervisory experience leading a team of scientists (including PhD-level scientists) and a track record of recruiting, mentoring, and developing top talent.&lt;/li&gt;
&lt;li&gt;Outstanding communication, collaboration, networking, and program leadership skills.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in a dynamic environment with a sense of urgency and creativity and focus on deliverables.&lt;/li&gt;
&lt;li&gt;Team player with a strong work ethic, able to work both independently and collaboratively&lt;/li&gt;
&lt;li&gt;Continuously learns and adapts quickly to new information&lt;/li&gt;
&lt;li&gt;Authentic, proactively appreciative of different points of view, backgrounds and perspectives&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Values and Behaviors&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking individuals with an entrepreneurial spirit, strong communication skills, outstanding organization skills and impeccable record keeping, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/strong&gt; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;/div&gt;

VP, Head of Data Science and Systems Biology 

&lt;p&gt;&lt;strong&gt;Senior Scientist/Principal Scientist : Innovation Team&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Harbinger Health, a Flagship-founded company, is pioneering early cancer detection. Harbinger aims to detect cancer, at the earliest stages, to save lives. Our platform leverages proprietary biological insights and artificial intelligence to enable high-resolution, molecular views on cancer from blood. We are a highly dynamic, entrepreneurial, and innovation-driven organization seeking collaborative, passionate, and dedicated people to join our team.&lt;/p&gt;
&lt;p&gt;Flagship Pioneering conceives, creates, resources, and develops first-in-category bioplatform companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in more than $200 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 42 transformative companies, including Axcella Health (Nasdaq: AXLA), Codiak BioSciences (Nasdaq: CDAK) Denali Therapeutics (Nasdaq: DNLI), Evelo Biosciences (Nasdaq: EVLO), Foghorn Therapeutics (Nasdaq: FHTX), Indigo Ag, Kaleido Biosciences (Nasdaq: KLDO), Moderna (Nasdaq: MRNA), Omega Therapeutics (Nasdaq: OMGA), Rubius Therapeutics (Nasdaq: RUBY), Sana Biotechnology (Nasdaq: SANA), Seres Therapeutics (Nasdaq: MCRB), and Sigil on Therapeutics (Nasdaq: SGTX).&lt;/p&gt;
&lt;p&gt;Harbinger Health is seeking a highly motivated &lt;strong&gt;Senior Scientist/Principal Scientist for the Innovation team&lt;/strong&gt;. This team generates novel technologies to enhance the product portfolio and drive diagnostic technologies forward. The successful candidate will be responsible for evaluating alternative target enrichment platforms (NGS-based and qPCR-based), optimizing assays, and performing clinical validations. &amp;nbsp;He/she must be highly-organized, analytically-minded with a strong commitment to the scientific process, and has a clear understanding of the impact assay development and innovation has on other aspects of a diagnostic process. &amp;nbsp;Experience with NGS assay workflow, various targeted enrichment approaches, as well as various analytical platforms such as ddPCR, for use in rare event detection a must. &amp;nbsp;Because of the start-up nature of Harbinger Health, this role will accelerate exposure to multiple facets of clinical diagnostic field, from nucleic acid preparation to data analysis, and overall bioassay development.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Plan, design, and execute complex experimental studies and meticulously record results in an electronic laboratory notebook (ELN)&lt;/li&gt;
&lt;li&gt;Perform comprehensive data analysis, write detailed reports, and present summary findings in company meetings&lt;/li&gt;
&lt;li&gt;Analytically troubleshoot to determine critical process parameters and conduct assay optimization to maintain and/or improve high-quality results generation while driving cost and complexity down&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;MS or PhD in Biological Sciences, Biomolecular Engineering, Biochemistry, Molecular Biology, or related discipline with 5-8 years of relevant experience in academia or industry laboratory setting focused on commercial diagnostics and assay development&lt;/li&gt;
&lt;li&gt;Solid understanding of genetics with expertise in molecular biology techniques such as nucleic acid purification, quantification, and PCR (standard amplification, qPCR, and/or ddPCR)&lt;/li&gt;
&lt;li&gt;Experience with NGS, specifically library preparation and enrichment techniques&lt;/li&gt;
&lt;li&gt;Experience with additional sequencing chemistries, such as long-read DNA sequencing is a plus.&lt;/li&gt;
&lt;li&gt;Experience with CRISPR-Cas techniques is a plus.&lt;/li&gt;
&lt;li&gt;Ability to multi-task and adapt to changes in workflows and priorities while delivering timely results to meet company goals&lt;/li&gt;
&lt;li&gt;Strong scientific curiosity to innovate by developing, re-engineering or combining existing analytical procedures resulting in improved performance and outcomes relative to specific product applications while retaining the discipline associated with clinical diagnostic technologies and processes&lt;/li&gt;
&lt;li&gt;Excellent organizational and communication skills&lt;/li&gt;
&lt;li&gt;Proficiency with data analysis software (ie. Prism or JMP) and Microsoft Office Suite (Excel, PowerPoint).&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.&amp;nbsp; The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.&amp;nbsp;&amp;nbsp; Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;

Harbinger : Senior Scientist / Principal Scientist : Innovation Team

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Job Summary: &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Tessera Therapeutics is seeking a highly motivated bioanalytical scientist to fulfill a Scientist I/II role in our DMPK group. The candidate will be responsible for developing and employing LC-MS methods to characterize and quantitate oligonucleotides and their metabolites to support research, non-Clinical, and clinical development programs for a variety of therapeutic indications. The ideal candidate must have excellent communication skills and is willing to work in a highly dynamic and fast-paced work environment.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop LC-MS methods for characterization and quantitation of oligonucleotides in various biological matrices including biofluids, tissues, cells, and subcellular fractions.&lt;/li&gt;
&lt;li&gt;Conduct metabolite identification experiments, analyze, and interpret data to understand oligonucleotide metabolism.&lt;/li&gt;
&lt;li&gt;Design and execute experiments from sample preparation, LC-MS/MS operation to data analysis &amp;amp; interpretation.&lt;/li&gt;
&lt;li&gt;Coordinate method transfer to CROs and serve as technical expert for method trouble shooting.&lt;/li&gt;
&lt;li&gt;Write method protocols and sample analysis procedures. Prepare bioanalytical and metabolite identification reports and data presentations.&lt;/li&gt;
&lt;li&gt;Provide maintenance, quality control and troubleshooting of high-resolution mass spectrometer as well as UPLC systems.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;strong&gt;Basic Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Chemistry or related discipline e.g., Biochemistry, Biotechnology or Pharmaceutical Science, with 0-3 years of industry experience in biotech, pharmaceutical, and/or CROs. Postdoc experience is a plus.&lt;/li&gt;
&lt;li&gt;Experience in high resolution mass spectrometric bioanalysis of oligonucleotides is a plus.&lt;/li&gt;
&lt;li&gt;In-depth scientific knowledge and hands on technical expertise on LC-MS, LC-MS/MS, and chromatography methodologies and instrumentation is required.&lt;/li&gt;
&lt;li&gt;Excellent organizational and communication skills.&lt;/li&gt;
&lt;li&gt;Ability to conduct multiple laboratory and project tasks efficiently.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Hands-on experience with RNA extraction from in vivo samples such as blood or tissue is a plus.&lt;/li&gt;
&lt;li&gt;Experience with downstream statistical and bioinformatics analysis is a plus.&lt;/li&gt;
&lt;li&gt;Experience in using software for LC-MS oligonucleotide data analysis is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;More About Flagship Pioneering&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering has conceived of and created companies such as&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Moderna&amp;nbsp;&lt;/em&gt;Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT),&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Omega Therapeutics&amp;nbsp;&lt;/em&gt;(NASDAQ: OMGA),&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Seres&amp;nbsp;&lt;/em&gt;Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.&amp;nbsp; The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.&amp;nbsp;&amp;nbsp; Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;
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&lt;/div&gt;

Scientist II/Senior Scientist, Delivery Biology

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL89, Inc. is a privately held early-stage company that is leveraging advanced biological and computational tools to develop breakthroughs in our understanding of secreted protein function and regulation in human physiology. More specifically, FL89 is pairing high throughput -omics technology with AI/ML based protein structure prediction to define and discover novel therapeutic protein biology.&lt;/p&gt;
&lt;p&gt;Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Part of a collaborative team with a focus on developing high-throughput next-generation sequencing platforms and cell models to enable discovery in the FL89 secretome platform. This individual will utilize previous experiences in generation and analyses of large next-generation sequencing datasets to drive development of a novel biological platform. The position will provide a unique opportunity to play a foundational role in the development of FL89’s preclinical platform.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Play a key role in developing, automating, and integrating new high throughput assay technologies into the FL89 Discovery Platform.&lt;/li&gt;
&lt;li&gt;Conceive, build, and optimize novel cell systems and generate NGS libraries at scale.&lt;/li&gt;
&lt;li&gt;Operate and execute cell stimulation and NGS library pipelines in high throughput.&lt;/li&gt;
&lt;li&gt;Track and maintain excellent data records in formats amenable to computational workflows.&lt;/li&gt;
&lt;li&gt;Maintain a meticulous electronic notebook and provide clear plans for upcoming experiments.&lt;/li&gt;
&lt;li&gt;Design, execute, and troubleshoot experiments as well as data analysis.&lt;/li&gt;
&lt;li&gt;Maintain lab notebooks and report data and analysis results to the scientific team.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Graduate degree in biology, bioengineering, biochemistry, or a related field&lt;/li&gt;
&lt;li&gt;2+ years of prior research experience in molecular biology and mammalian cell culture&lt;/li&gt;
&lt;li&gt;2+ years in high-throughput protein biology&lt;/li&gt;
&lt;li&gt;Strong familiarity with sterile technique and thawing, culture, and freezing of mammalian cells&lt;/li&gt;
&lt;li&gt;Understanding of key principles of biological data analysis and statistics&lt;/li&gt;
&lt;li&gt;Strong experience in assay development, miniaturization and performing HTP screens, using primary/stem cells, preferably in industry.&lt;/li&gt;
&lt;li&gt;Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc.&lt;/li&gt;
&lt;li&gt;Strong analytical and problem-solving skills are a must!&lt;/li&gt;
&lt;li&gt;Must have strong attention to detail in a rapidly changing environment &lt;/li&gt;
&lt;li&gt;Adaptability, resourcefulness, and strong verbal communications skills will be necessary to integrate into this team environment &lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Requirements&lt;em&gt;:&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Prior research experience in industry&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Prior experience with NGS library processing and Illumina instruments.&lt;/li&gt;
&lt;li&gt;Knowledge of NGS data analysis, especially QC metrics including FASTQC and downstream processing&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering is committed to&amp;nbsp;&lt;strong&gt;equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
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Scientist, Platform Biology

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?&lt;/p&gt;
&lt;p&gt;Metaphore Biotechnologies is an early-stage biotechnology company with an ambitious and exciting mission: to reimagine drug discovery and vaccine design. The company is developing a first-in-class platform for the intelligent design of molecular mimicry. Our platform integrates massively parallel assays with machine-learning-guided protein engineering to navigate the combinatorial space of molecular interactions and design protein-protein interfaces with exquisite precision.&lt;/p&gt;
&lt;p&gt;Metaphore Biotechnologies is a product of Flagship Pioneering&#x27;s venture creation engine, which has also given rise to companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary&lt;/strong&gt;:&lt;/p&gt;
&lt;p&gt;We are seeking a motivated Computational Immunologist to join our rapidly growing team. The successful candidate will conduct immune repertoire analysis with highly parallel assay data and computational modeling to support the discovery, engineering, and evaluation of novel therapeutic antibodies and vaccines. They will play a key role in our discovery through translational efforts, formulating and executing on a science &amp;amp; technology strategy that will allow the company to deliver against its goals.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;This position requires a strong foundation in the biology of the adaptive immune system and computational immune repertoire analysis, including interrogation of large in vitro and in vivo experiments to characterize determinants of immune receptor specificity and the response to candidate therapeutics and vaccination strategies. &amp;nbsp;The candidate will work closely with experimental and computational scientists to interpret results and design experiments.&amp;nbsp; This individual will join an interdisciplinary and collaborative team at the interface of computational immunology, functional genomics, and next-generation antibody design; they should be comfortable communicating and working with diverse backgrounds in a fast-paced startup environment.&lt;/p&gt;
&lt;p&gt;The candidate will have an extraordinary opportunity to be part of the Flagship ecosystem of companies providing unique networking benefits through regular meetups, collaboration, and an environment of development and discussion around new ideas shaping the fields of computational biology and ML/AI.&lt;/p&gt;
&lt;p&gt;In the interest of fostering collaboration, the candidate is expected to work on-site at our Kendall Square, Cambridge, MA location.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Explore, design, and implement bioinformatic algorithms for immune repertoire analysis&lt;/li&gt;
&lt;li&gt;Assist the design of screening libraries and build NGS analysis pipelines for hit identification&lt;/li&gt;
&lt;li&gt;Formulate hypotheses, aid experimental design and perform analyses to evaluate novel immunization strategies&lt;/li&gt;
&lt;li&gt;Collaborate with team members to interpret immunogenicity&lt;/li&gt;
&lt;li&gt;Leverage internal and external datasets to further develop our ML-guided protein-interface engineering platform&lt;/li&gt;
&lt;li&gt;Collaborate with engineers, computation scientists, and experimentalists to execute on company goals&lt;/li&gt;
&lt;li&gt;Communicate insights and conclusions to colleagues in the scientific and leadership teams&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. plus 2-5 years of experience in computational biology, bioinformatics, immunology, or a related field&lt;/li&gt;
&lt;li&gt;Strong skills in immune repertoire analysis, particularly as pertains to understanding antibody maturation and the repertoire response to vaccination&lt;/li&gt;
&lt;li&gt;Experience with NGS data pipelines and analysis&lt;/li&gt;
&lt;li&gt;Excellent understanding of statistics&lt;/li&gt;
&lt;li&gt;Strong programming skills in Python (preferably) or R and knowledge of software best practices&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with protein engineering or vaccine development&lt;/li&gt;
&lt;li&gt;Experience with machine learning, especially in the context of biomolecules&lt;/li&gt;
&lt;li&gt;Experience with publicly available data sources such as IMGT, OAS or ImmPort&lt;/li&gt;
&lt;li&gt;Experience with cloud and/or distributed computing&lt;/li&gt;
&lt;li&gt;Experience with single cell immune profiling&lt;/li&gt;
&lt;li&gt;Laboratory experience in molecular biology or immunology&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Values and Behaviors:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidates.&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Scientist, Computational Biology

&lt;p&gt;&lt;strong&gt;Scientist/Sr. Scientist, Health Data Science&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as &amp;gt;95% of global healthcare costs are spent on treating rather than preventing chronic diseases. FL84, Inc. is a privately held early-stage company that is applying advanced biological and computational platforms to discover breakthroughs in detection of and intervention against the etiologies that drive progression from health to disease. Our goal is to leverage our proprietary platforms to disrupt the current approach of treating chronic disease too late. We endeavor to provide true health care rather than sick care to individuals that are at risk of progressing to disease.&lt;/p&gt;
&lt;p&gt;FL84 was founded by Flagship Pioneering, an innovation enterprise dedicated to originating and developing first-in-category life sciences companies. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a &lt;strong&gt;Scientist, Health Data Science&lt;/strong&gt; who is enthusiastic about developing, learning and applying computational skills to understand complex clinical trajectories from healthy to disease. The role will include significant hands-on analyses of clinical data such as electronic health records, insurance claims, laboratory measurements, images, and genetic data. The candidate will work closely with the computational biology team to develop insights and novel prediction platforms for different stages of the journey from health to disease.&amp;nbsp; An ideal candidate will pride themselves on their interest and potential in crafting scientifically explainable stories out of complex data and convert them into executable clinical study designs. The position will provide a unique opportunity to play a foundational role in the development of FL84’s preclinical platform.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work with FL84 team to develop and apply novel ML models (e.g., disease progression models, among others) on clinical data (EHR, insurance claims, labs, imaging, narrative notes, etc.)&lt;/li&gt;
&lt;li&gt;Develop prediction algorithms to detect with reasonably high success individuals before major changes in their health and forecast their time to detectable transition&lt;/li&gt;
&lt;li&gt;Develop methodologies to estimate rate-of-change for individuals between stages in health&lt;/li&gt;
&lt;li&gt;Ideate on how to align clinically relevant inflection points identified in electronic health records, clinical trials, or other sources with time-series biological data.&lt;/li&gt;
&lt;li&gt;Identify and explore internal and external clinical datasets to address questions critical to FL84’s core objectives and generate testable hypotheses&lt;/li&gt;
&lt;li&gt;Develop clear, intuitive visualizations and communicate analysis results via presentations to a multi-disciplinary audience&lt;/li&gt;
&lt;li&gt;Cultivate a data-centric and process-oriented company philosophy by helping to maintain best practices for software development, data management, and infrastructure&lt;/li&gt;
&lt;li&gt;Monitor and evaluate new and emerging technologies and models and identify opportunities for collaboration within Flagship Pioneering companies, academia, and third parties&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD or equivalent level of experience in applying machine learning/artificial intelligence to large-scale clinical data. PhD may be in Biomedical Informatics, Bioinformatics, Machine Learning, Statistics, Computer Science, Data Science, Mathematics, or similar technical fields&lt;/li&gt;
&lt;li&gt;Demonstrated experience applying deep learning models to electronic health record or administrative claims data&lt;/li&gt;
&lt;li&gt;Fluency in Python and experience with R and SQL&lt;/li&gt;
&lt;li&gt;Familiarity with common machine-learning/deep-learning packages such as scikit-learn, TensorFlow and PyTorch&lt;/li&gt;
&lt;li&gt;Familiarity with AWS, GCP, or similar cloud-computing services&lt;/li&gt;
&lt;li&gt;Ability to thrive in an entrepreneurial and multidisciplinary environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience in one or more of the following areas/topics: regression models, regularization, time-series models, survival analysis, recurrent neural networks, graph neural networks, LSTMs, NLP or CNNs&lt;/li&gt;
&lt;li&gt;Experience developing forecasting algorithms for time-series data&lt;/li&gt;
&lt;li&gt;Experience working with reference clinical databases and datasets (e.g., MIMIC, UK Biobank, TCGA, PCORnet) is a strong plus&lt;/li&gt;
&lt;li&gt;Ability to Google error messages and seek resolution from self-investigation&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering is committed to&amp;nbsp;&lt;strong&gt;equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp;Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;

Scientist/Sr. Scientist, Health Data Science

&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?&lt;/p&gt;
&lt;p&gt;Flagship Pioneering&#x27;s venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12thglobally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Company:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL86, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Responsible for the translational validation of discovery platform targets in cell-based and in disease-relevant pharmacological models&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;The successful candidate will work both independently and as part of a team to design, plan and execute high-quality biochemical, cell-based and translational assays&lt;/li&gt;
&lt;li&gt;Lead the development and execution of cell-based assays to assess biological signaling pathways, the biological activity of small molecules, biologics or nucleotide-based compounds&lt;/li&gt;
&lt;li&gt;Define tissue and disease-specific target engagement levels, establish, and run biomarker plans and translational PK/PD assessment&lt;/li&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Mentor and train research associates as needed&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Bioengineering or related discipline with &amp;gt; 0 - 5 years of experience in a biotech or pharmaceutical company (the title will be adjusted for the level of experience).&lt;/li&gt;
&lt;li&gt;Deep knowledge and understanding of cell biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation.&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience in mammalian cell culture including primary cells and in handling tissues.&lt;/li&gt;
&lt;li&gt;The ideal candidate has previous experience in cell-culture assays of cardiometabolic diseases (e.g., Diabetes, Heart Disease, Fatty Liver Disease) and relevant cell culture lines (e.g., Myocyte, Hepatocyte, pancreatic). Experience in RNA biochemistry and structural biology, cell-based genetic manipulations (e.g., siRNA, ASO) and RNA/DNA delivery is a plus.&lt;/li&gt;
&lt;li&gt;Experience in the following techniques is a plus: FACS, RT-qPCR, RNA-seq, cloning, cell culture, microscopy, IHC and quantitative image analysis, Meso Scale Discovery, HALO image analysis software.&lt;/li&gt;
&lt;li&gt;Strong written and oral presentation skills&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Attributes:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with translational cell-based and pharmacology models&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Location:&lt;/strong&gt; Cambridge, MA&amp;nbsp;&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;

Scientist, Cardiometabolic Cell Biology 

&lt;p&gt;FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.&lt;/p&gt;
&lt;p&gt;FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are searching for an experienced Senior/Principal Scientist to drive computational innovation in a well-funded biotech pioneering novel nucleic acid therapeutics. We are looking for an individual who is excited to innovate a new class of programmable medicines. This individual is expected to bring excellent scientific rigor and creativity, and a track record of using diverse computational methods to create value. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative and rapidly growing team.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Play a leading role in advancing platform development by using computational methods to drive innovation&lt;/li&gt;
&lt;li&gt;Develop and perform bioinformatics analyses, such as on bulk and single-cell DNA/RNA sequencing data, or publicly available databases for sequences and biological insights of interest&lt;/li&gt;
&lt;li&gt;Analyze, troubleshoot, and communicate findings clearly and succinctly in oral, written, and visual formats&lt;/li&gt;
&lt;li&gt;Prepare written and visual materials for internal and external audiences&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Work independently and collaboratively in a multidisciplinary team environment&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in relevant discipline (Genomics, Computational Biology, etc.) with &amp;gt;3 years of industry experience&lt;/li&gt;
&lt;li&gt;Extensive working experience with analyzing data from diverse sequencing platforms, including Illumina (bulk and single-cell), Oxford Nanopore MinION, and Sanger -&lt;/li&gt;
&lt;li&gt;Extensive working experience with relevant programming languages, including Linux, R, and Python&lt;/li&gt;
&lt;li&gt;Extensive working experience with AWS infrastructure and pipeline development methods (Docker, Snakemake, etc.)&lt;/li&gt;
&lt;li&gt;Strong communication, team leadership, and interpersonal skills.&lt;/li&gt;
&lt;li&gt;Track record of working effectively in a multidisciplinary environment, interacting with teams from other line functions&lt;/li&gt;
&lt;li&gt;Strong organizational, analytical, problem-solving, and project management skills.&lt;/li&gt;
&lt;li&gt;Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech &lt;br&gt;&lt;br&gt;&lt;/li&gt;
&lt;/ul&gt;

Sr/Principal Scientist, Computational Biology

&lt;p&gt;At Flagship Pioneering, we conceive, create, resource, and develop first-in-category life sciences companies to transform human health and sustainability. We’ve created over 100 scientific ventures, including the now familiar drug and vaccine innovator, Moderna Therapeutics.&lt;/p&gt;
&lt;p&gt;Since its inception in 2000, many of our companies have leveraging advances in computing, big data, and AI. In recent years, this trend has accelerated with first-in-category life science companies such as&amp;nbsp;Generate Biomedicines, Cellarity, Valo and many others that are creating breakthrough innovations using AI and ML technologies.&lt;/p&gt;
&lt;p&gt;We are looking for extraordinary computational scientists, engineers, and entrepreneurs to work alongside individuals within the Flagship Ecosystem focused on solving the most impactful challenges in AI and the life sciences.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Our ML Engineering interns will work closely with an interdisciplinary team of ML scientists to design and implement ML tools with biological impact and evaluate their strengths and limitations. Projects will have a focus on end-to-end execution, to expose interns to the full development cycle.&amp;nbsp;This is an exciting opportunity to be part of a fast-paced, highly dynamic entrepreneurial environment.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work with interdisciplinary team of scientists to apply SOTA and/or internally-developed ML methods to impactful biological problems&lt;/li&gt;
&lt;li&gt;Work with our engineers to improve or develop infrastructure to enable new classes of ML methods&lt;/li&gt;
&lt;li&gt;Develop clear, intuitive visualizations. Communicate results via presentations to a multi-disciplinary audience.&lt;/li&gt;
&lt;li&gt;Cultivate a data-centric and process-oriented company philosophy by following and maintaining best practices for software development, data management, and infrastructure.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Current undergraduate or master’s degree student in computer science, machine learning&lt;/li&gt;
&lt;li&gt;Fluency in Python and standard ML tools and packages.&lt;/li&gt;
&lt;li&gt;Familiarity with AWS, GCP, or similar cloud-computing services.&lt;/li&gt;
&lt;li&gt;Attention to detail and ability to produce clean, well-documented code.&lt;/li&gt;
&lt;li&gt;Familiarity with common SWE tools such as Git, Docker, and Kubernetes.&lt;/li&gt;
&lt;li&gt;Motivated and team oriented, with an ability to thrive in an entrepreneurial and multidisciplinary environment.&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills. Must be able to think independently and work collaboratively.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;

Pioneering Intelligence: Machine Learning Engineer Co-Op

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Arana Biosciences is one of the latest companies founded through Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics and Evelo Therapeutics were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of nearly 100 scientific ventures resulting in $19+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Arana Biosciences is integrating the latest developments in molecular biology and plant biology to create a new platform technology that enables adaptive, targeted and sustainable solutions in agriculture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Sum&lt;/strong&gt;&lt;strong&gt;mary&lt;/strong&gt;&lt;strong&gt;:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a curious and inspired Computational Biologist with expertise in viral biology and novel genome discovery and assembly from environmental sequencing data to join our passionate team at Arana Biosciencesto revolutionize agriculture. You will tackle computational challenges to discover novel microorganisms and viruses, and interface directly with molecular engineering teams to test your discoveries. In conjunction with experimentalists, you will analyze next-generation sequencing data from an ecological and functional perspective to build our platform technology. Your role will involve aspects of data management/infrastructure to build automated/standalone pipelines. You will be a key player to translate early-stage discovery to empirical lab validation. You thrive in a fast-paced entrepreneurial environment as an integral part of a highly collaborative and interdisciplinary team. The level of the role will be determined by education and years of experience.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Analyze next-generation sequencing data to discover novel sequences of interest&lt;/li&gt;
&lt;li&gt;Assemble and annotate novel viral genomes and RNA features from metagenomic and metatranscriptomic data, and develop new computational methods or leverage existing methodologies&lt;/li&gt;
&lt;li&gt;Create and maintain pipelines for processing high-throughput next-generation sequencing data for comparative genomics and gene discovery studies&lt;/li&gt;
&lt;li&gt;Develop and refine systems to aggregate and prioritize discovered sequences for empirical validation and testing by our molecular engineering and cloning teams&lt;/li&gt;
&lt;li&gt;Maintain scientific and technical expertise through familiarity with scientific literature, attending conferences, and developing relationships with thought leaders&lt;/li&gt;
&lt;li&gt;Work closely with an entrepreneurial, highly-collaborative, interdisciplinary team and actively contribute to creating, shaping, and executing the scientific and strategic vision of the company&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Minimum Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Computational Biology, RNA Biology, Bioinformatics, Viral Ecology, Comparative Genomics, or related field&lt;/li&gt;
&lt;li&gt;Strong expertise in new functional gene discovery from shotgun sequencing datasets, with experience evaluating multiple tools and approaches&lt;/li&gt;
&lt;li&gt;Deep understanding of genomic and transcriptomic assembly methods.&lt;/li&gt;
&lt;li&gt;Extensive experience interfacing with molecular teams to streamline wet lab and computational discovery and functional assay analysis&lt;/li&gt;
&lt;li&gt;Strong programming experience in Python or R&lt;/li&gt;
&lt;li&gt;A strong self-starter, independent thinker, with attention to detail&lt;/li&gt;
&lt;li&gt;Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner&lt;/li&gt;
&lt;li&gt;Confident, execution-focused, and team-oriented to thrive in an entrepreneurial environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Expertise in viral biology and genomics&lt;/li&gt;
&lt;li&gt;Proficiency in creating reproducible workflows using Nextflow and Docker, and working in cloud computing environments such as Amazon Web Services&lt;/li&gt;
&lt;li&gt;Experience in creating dashboards or other utilities to allow biologists to investigate data independently&lt;/li&gt;
&lt;li&gt;Experience establishing automated pipelines for hybrid assembly and analysis for both long-read (Pac Bio and Nanopore) and short-read (Illumina) NGS sequencing technology&lt;/li&gt;
&lt;li&gt;Industry experience with project management and big data management&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Location: &lt;/strong&gt;Cambridge, MA&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;More About Flagship Pioneering&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Computational Biologist, Viral Genomics

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&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt;you could join an organization that creates, resources and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 75, Inc. (FL75) is a privately held, early-stage biotechnology company that is pioneering the development of multi-specific medicines to systematically drug complex biology. FL75 is a highly dynamic, entrepreneurial, and innovation-driven organization seeking an exceptional assay developer to join our team. We are a small company with ambitious plans for growth.&lt;/p&gt;
&lt;p&gt;FL75 was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. Since Flagship’s founding in 2000, the firm has originated more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 75, Inc is looking for a highly motivated and enthusiastic team member to join our biology team, conducting cell-based and &lt;em&gt;ex vivo &lt;/em&gt;studies of antibodies and related biological molecules. Grade will be matched to the level of experience. This is an exciting opportunity to contribute to the development of the next generation of biologics in a dynamic and entrepreneurial environment. We are located in the Boston area, and this is an in-person lab-based position.&lt;/p&gt;
&lt;p&gt;We are seeking creative, curious, and resourceful team members to integrate into a research and development company developing and applying new scientific platforms for use in disease treatment. This individual will be responsible for experiments using cell biology, flow cytometry, histology and other imaging techniques.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Testing binding and function of antibodies and other protein-based therapeutics.&lt;/li&gt;
&lt;li&gt;Performing cell-based assays such as immunophenotyping, signal transduction, cytokine expression, cellular differentiation, and gene expression assays.&lt;/li&gt;
&lt;li&gt;Imaging assays using techniques including immunohistochemistry, immunofluorescence and/or immunocytochemistry.&lt;/li&gt;
&lt;li&gt;Image analysis using AI and machine learning systems.&lt;/li&gt;
&lt;li&gt;Communicating results &amp;amp; accurate record keeping using an ELN.&lt;/li&gt;
&lt;li&gt;Assisting in lab organization including ordering supplies, restocking and results cataloguing.&lt;/li&gt;
&lt;li&gt;Maintaining mammalian cell-lines.&lt;/li&gt;
&lt;li&gt;Performing transfections, protein over-expression, knock-down and other genetic manipulation.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications and Capabilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A Bachelor’s or Master’s degree in Biology or related field.&lt;/li&gt;
&lt;li&gt;2 years minimum of biology lab experience in academic or biotech settings is preferred.&lt;/li&gt;
&lt;li&gt;Significant experience in either multi-color flow cytometry or IHC/IF, including both conducting experiments and data analysis.&lt;/li&gt;
&lt;li&gt;Self-motivated and eager to learn new techniques.&lt;/li&gt;
&lt;li&gt;Ability to work in a dynamic and fast-paced environment.&lt;/li&gt;
&lt;li&gt;Strong collaboration and communication skills are essential.&lt;/li&gt;
&lt;li&gt;Aptitude for detail-orientated work is essential.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Desired Experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Proficiency with cell culture, aseptic technique &amp;amp; transfection.&lt;/li&gt;
&lt;li&gt;Familiarity with protein analysis such as western blotting &amp;amp; ELISA.&lt;/li&gt;
&lt;li&gt;Experience using FlowJo or similar software for flow cytometry analysis.&lt;/li&gt;
&lt;li&gt;Experience with multicolor immunofluorescence, brightfield immunohistochemistry and/or immunocytochemistry.&lt;/li&gt;
&lt;li&gt;Experience with image analysis software such as Aivia, HALO or Image J is a plus.&lt;/li&gt;
&lt;li&gt;Experience with cell activity assays, such as luciferase, cytokine secretion &amp;amp; qPCR is a plus.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering is committed to &lt;strong&gt;equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;/div&gt;

FL75: Sr. Research Associate/Associate Scientist, Cell Biology and/or Immunohistochemistry

&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?&lt;/p&gt;
&lt;p&gt;Flagship Pioneering&#x27;s venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12thglobally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Company:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL86, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Responsible for the translational validation of discovery platform targets in cell-based and in disease-relevant pharmacological models&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;The successful candidate will work both independently and as part of a team to design, plan and execute high-quality biochemical, cell-based and translational assays&lt;/li&gt;
&lt;li&gt;Lead the development and execution of cell-based assays to assess biological signaling pathways, the biological activity of small molecules, biologics or nucleotide-based compounds&lt;/li&gt;
&lt;li&gt;Define tissue and disease-specific target engagement levels, establish, and run biomarker plans and translational PK/PD assessment&lt;/li&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Mentor and train research associates as needed&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Bioengineering or related discipline with &amp;gt; 5-8 years of experience in a biotech or pharmaceutical company (the title will be adjusted for the level of experience)&lt;/li&gt;
&lt;li&gt;Deep knowledge and understanding of cell biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience in mammalian cell culture including primary cells and in handling tissues&lt;/li&gt;
&lt;li&gt;The ideal candidate has previous experience in RNA biochemistry and structural biology, cell-based genetic manipulations (e.g., siRNA, ASO) and RNA/DNA delivery&lt;/li&gt;
&lt;li&gt;Experience in the following techniques is a plus: FACS, RT-qPCR, RNA-seq, cloning, cell culture, IHC and quantitative image analysis, Meso Scale Discovery, HALO image analysis software.&lt;/li&gt;
&lt;li&gt;Strong written and oral presentation skills&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Attributes:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with translational cell-based and pharmacology models&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&lt;strong&gt;Location:&lt;/strong&gt; Cambridge, MA&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;

Principal Scientist, Cell Biology 

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.&lt;/p&gt;
&lt;p&gt;FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Sr. Research Associate will be primarily responsible for testing new gene therapy technology in mammalian cells. This individual will join a dynamic, rapidly growing, and highly collaborative team that combines significant biologic drug discovery experience with pioneering discoveries driving a novel biological platform.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Performs research and/or development in collaboration with others&lt;/li&gt;
&lt;li&gt;Makes detailed observations, analyzes data and interprets results&lt;/li&gt;
&lt;li&gt;Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project goals&lt;/li&gt;
&lt;li&gt;Prepares technical reports, summaries, protocols, and quantitative analyses.&lt;/li&gt;
&lt;li&gt;Investigates, creates and develops new methods and technologies for project advancement&lt;/li&gt;
&lt;li&gt;Maintains high level of professional expertise through familiarity with scientific literature and novel technologies&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications (one or more): &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Mammalian biology: cell culture, transfection and/or transduction, flow cytometry analysis, rtPCR, next generation sequencing, fluorescent and bioluminescent microscopy, western blotting, ELISA.&lt;/li&gt;
&lt;li&gt;Gene editing experience: using Cas9 or other approach therapeutically and quantitatively assaying editing efficiency and accuracy with state of the art technology.&lt;/li&gt;
&lt;li&gt;Gene therapy experience: AAV, liposome-mediated delivery of DNA or mRNA.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;M.S. or B.S. in Biological Engineering, Genetics, Molecular Biology, Immunology or related field.&lt;/li&gt;
&lt;li&gt;2+ years of industry experience is preferred.&lt;/li&gt;
&lt;li&gt;A strong self-starter, independent thinker, with a strong attention to detail.&lt;/li&gt;
&lt;li&gt;Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals or drug development is required&lt;/li&gt;
&lt;li&gt;Proven hands-on experience with cell-based and molecular biology assays with a variety of readout technologies, such as, but not limited to: flow cytometry, microscopy, mRNA expression analysis, western blotting.&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.&lt;/li&gt;
&lt;li&gt;Eager to work with highly-skilled and dynamic teams in a fast-paced, entrepreneurial and technical setting.&lt;/li&gt;
&lt;li&gt;Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;More About Flagship Pioneering&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are creative optimists and we would love for you to consider joining our team!&amp;nbsp; See &lt;a href=&quot;https://www.flagshippioneering.com/join/roles&quot;&gt;all our open opportunities&lt;/a&gt; across Flagship Pioneering’s Ecosystem!&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://www.flagshippioneering.com/&quot;&gt;Flagship Pioneering&lt;/a&gt; conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including:&amp;nbsp; Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO),&amp;nbsp; Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).&lt;/p&gt;
&lt;p&gt;We believe pioneering is best done by teams, and that it is a process that can be taught, learned, and replicated.&amp;nbsp; Learn more about our &lt;a href=&quot;https://www.flagshippioneering.com/process&quot;&gt;Company Creation Model&lt;/a&gt;.&lt;/p&gt;
&lt;p&gt;Can Breakthrough Innovations Be Made Systematically&lt;a href=&quot;https://www.flagshippioneering.com/stories/can-innovations-be-made-systematically-a-conversation-with-noubar-afeyan&quot;&gt;? A Conversation With Noubar Afeyan&lt;/a&gt;, Flagship Pioneering’s CEO.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;Flagship Pioneering and our ecosystem companies are committed to &lt;strong&gt;equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/strong&gt;&amp;nbsp; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.&amp;nbsp; The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.&amp;nbsp;&amp;nbsp; Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/p&gt;
&lt;/div&gt;

Senior Research Associate, Cell Biology 

&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is pioneering a platform that offers a completely novel way of modulating human biology via Endless RNA™ (eRNA). eRNA is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. Laronde is rapidly scaling to support the development of multiple programs across many disease areas.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has a highly collaborative, dedicated culture, driven to achieve our vision of “making eRNA an essential class of medicines to everyone, everywhere”. To learn more, please visit the company’s website at https://www.laronde.bio.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is seeking an outstanding Drug Delivery Scientist to join Laronde’s Targeted Delivery team that is pushing the boundaries and potential of a new class of RNA therapeutics. The position will play an integral role in a multidisciplinary team that seeks to push the possibilities of endless RNA therapeutics.&amp;nbsp;&lt;br&gt;&lt;br&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bioconjugation of targeting motifs for development of novel eRNA&lt;/li&gt;
&lt;li&gt;Purification of synthetic biologics and downstream analytical methods&lt;/li&gt;
&lt;li&gt;Protein conjugation and other biochemical linkage techniques&lt;/li&gt;
&lt;li&gt;Running of gels of different formats for the analysis of nucleic acids and proteins&lt;/li&gt;
&lt;li&gt;Critical data analysis skills, attention to details and troubleshooting abilities.&lt;/li&gt;
&lt;li&gt;Maintain detailed records of experimental protocols and data in electronic laboratory notebook in accordance with company policy.&lt;/li&gt;
&lt;li&gt;Effectively collaborate with a fully integrated research team to facilitate the success of projects.&lt;/li&gt;
&lt;li&gt;Excellent organizational skills and documentation practices.&lt;/li&gt;
&lt;li&gt;Additional duties and responsibilities as required.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Chemistry, Biochemistry, Cell Biology or a related field, or MS with 8+ years, or BS with 12+ years’ experience in industry or academia is required&lt;/li&gt;
&lt;li&gt;Experience with conjugation /strategies of ligands for drug delivery&lt;/li&gt;
&lt;li&gt;Chemistry experience such as organic synthesis, HPLC, purification methods, NMR and/or LCMS&lt;/li&gt;
&lt;li&gt;Experience with linker chemistry or antibody-drug conjugates (ADCs)&lt;/li&gt;
&lt;li&gt;Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial, and technical environment&lt;/li&gt;
&lt;li&gt;Excellent communication, scientific writing, and presentation skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Additional helpful experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with tissue culture, transfections, biochemical assays, or protein characterization&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Laronde is &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;&lt;/em&gt;&lt;em&gt;: Laronde does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Laronde or its employees is strictly prohibited unless contacted directly by Laronde’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Laronde, and Laronde will not owe any referral or other fees with respect thereto&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Scientist I , Targeted Delivery Bioconjugation

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&lt;p&gt;&lt;strong&gt;Company Summary: &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt;you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?&lt;/p&gt;
&lt;p&gt;Montai Health is a privately held, early-stage biotechnology company developing a platform for understanding and leveraging complex molecular interactions within organisms to solve global challenges in human health and sustainability. The company leverages a multidisciplinary approach that integrates tools ranging from machine learning and big data to multi-omics and high-throughput screening.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Montai&lt;/em&gt;&amp;nbsp;Health is seeking a creative, motivated&amp;nbsp;&lt;strong&gt;Scientist, Analytics Development&lt;/strong&gt;&amp;nbsp;to play a role in the Delivery team’s efforts to identify and characterize natural products, and formulations. S/he will be an expert in various analytical processes needed for oral delivery systems of small molecules, natural products, and related samples. The candidate will contribute critically to shaping the vision and strategy of the Delivery team. S/he will bring a strong entrepreneurial orientation, demonstrate strong communication skills, and be comfortable working in and contributing to a very dynamic and cross-functional team environment. As a member of this early team of scientists, you can expect to engage deeply in interdisciplinary research. Employees will enjoy a dynamic, rapidly expanding organization that will have a broad impact on human health. We offer a competitive starting salary and benefits.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and implement novel biochemical and biophysical analysis methodology to characterize natural products, novel delivery formulations, and&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;pharmacokinetics of small molecules&lt;/li&gt;
&lt;li&gt;Develop and contribute to pre-formulation and formulation analysis of natural products and small molecules&lt;/li&gt;
&lt;li&gt;Oversee in-house instruments, including maintenance, troubleshooting, and method development/optimization&lt;/li&gt;
&lt;li&gt;Identify and collaborate with CROs to fulfill analytical needs of the projects&lt;/li&gt;
&lt;li&gt;Collaborate closely with other computational and wet lab scientists – wear multiple hats as needed in a fast-paced environment&lt;/li&gt;
&lt;li&gt;Report results to scientific team and management.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. focusing on Analytical Chemistry, Natural Product Chemistry, Biochemistry, Biological Engineering and/or related field or equivalent experience.&lt;/li&gt;
&lt;li&gt;2-5+ years of industry experience with natural products and/or small molecule analysis with diverse analytical chemistry techniques, including HPLC, LC-MS/MS, etc.&lt;/li&gt;
&lt;li&gt;Experience with analytical development on lipid-based formulations and oral delivery systems is a plus&lt;/li&gt;
&lt;li&gt;Ability to learn cross-team scientific functions and wear multiple hats in a small company setting&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner&lt;/li&gt;
&lt;li&gt;Self-driven and demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial setting&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Senior Scientist/Scientist, Analytics Development

&lt;div class=&quot;content-intro&quot;&gt;&lt;p&gt;Vizgen, Inc. – Cambridge, MA&lt;/p&gt;
&lt;p&gt;&lt;br&gt;Vizgen is a rapidly growing company developing the next generation of spatially resolved genomic profiling tools that enable researchers to gain new insight into the biological systems that underlie human health and disease. The company&#x27;s groundbreaking MERFISH spatial transcriptomics technology images RNA molecules with high accuracy and unrivaled detection efficiency at subcellular resolution. MERFISH provides transformative insight into a wide range of tissue-scale basic research and translational medicine in oncology, immunology, neuroscience, infectious disease, developmental biology, and regenerative medicine. For more information, go to www.vizgen.com&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&lt;strong&gt;Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Senior Bioinformatics Applications Scientist with a proven track record of establishing standardized bioinformatics analysis procedures to address diverse biological applications using genomics data. The Bioinformatics Applications Scientist will be responsible for leading the evaluation of available tools and standardizing analysis frameworks for users of Vizgen’s MERSCOPE platform. As a Bioinformatics Applications Scientist at Vizgen, you will drive successful engagement with Vizgen’s spatial transcriptomic data among the research community through establishing a comprehensive analysis framework that enables researchers to identify the best analysis for their biological question. The ideal candidate will have experience analyzing data from single-cell gene expression, immunofluorescence, FISH, and/or spatial gene expression experiments. This is an exciting opportunity for an experienced and driven individual to become an expert on the next generation of genomics technologies while working in a fast-paced, dynamic company.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What will you be doing:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead development of an analysis framework for reaching biologically relevant conclusions from data generated by Vizgen’s MERSCOPE platform.&lt;/li&gt;
&lt;li&gt;Document and track analysis trends from emerging spatial transcriptomics demonstrations and publications.&lt;/li&gt;
&lt;li&gt;Plan and execute validation testing plans for Vizgen’s new bioinformatics tools to ensure biological results from the tools are robust and valid.&lt;/li&gt;
&lt;li&gt;Help the product development group compile customer bioinformatics requirements for new Vizgen-developed analysis tools.&lt;/li&gt;
&lt;li&gt;Serve as an externally-facing expert on Vizgen software, data, and bioinformatics products.&lt;/li&gt;
&lt;li&gt;Facilitate integration with bioinformatics tools developed by external partners or academic groups.&lt;/li&gt;
&lt;li&gt;Provide timely and expert resolutions to escalated issues and questions.&lt;/li&gt;
&lt;li&gt;Consolidate and represent customer and partner feedback to communicate to the internal R&amp;amp;D teams to refine user experience and ensure Vizgen customers are able to easily perform the analysis that is needed for their research.&lt;/li&gt;
&lt;li&gt;Build accessible software training material and tutorials for internal and external customers running MERSCOPE measurements and partners interested in integrating MERSCOPE output into their 3&lt;sup&gt;rd&lt;/sup&gt; party tools.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Lead internal bioinformatics training for the sales, field support, and lab services groups.&lt;/li&gt;
&lt;li&gt;Travel to meet with customers and field teams at trade shows, seminars, and technical meetings.&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;To be successful in this role, you must have:&lt;/strong&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;5+ years of Bioinformatics experience&lt;/li&gt;
&lt;li&gt;PhD in Biology, Bioinformatics, Computer Science, or similar discipline or equivalent work experience&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Strong background in statistics&lt;/li&gt;
&lt;li&gt;Demonstrated experience implementing, troubleshooting and supporting bioinformatics software and pipelines.&lt;/li&gt;
&lt;li&gt;Demonstrated experience establishing and maintaining successful collaborations and partnerships&lt;/li&gt;
&lt;li&gt;Strong scripting and programming experience.&lt;/li&gt;
&lt;li&gt;Experience with Amazon AWS, GCP, Linux, and high performance computing.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to help wetlab scientist understand their data.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have skills &amp;amp; experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience analyzing spatial transcriptomic data&lt;/li&gt;
&lt;li&gt;Experience leading a bioinformatics group&lt;/li&gt;
&lt;li&gt;Expertise in neuroscience or oncology&lt;/li&gt;
&lt;li&gt;Experience contributing to open source software projects&lt;/li&gt;
&lt;li&gt;Experience with image processing and spatial analysis&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;#LI-DNI&lt;/p&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;p&gt;If you aren&#x27;t sure you meet every requirement but are excited about what you read here, please consider applying! We believe diversity drives innovation.&amp;nbsp; Above all, we&#x27;re looking for the right person with skills and talent to grow the company together all while enriching your professional and scientific experience.&lt;/p&gt;
&lt;p&gt;We offer a competitive salary, meaningful stock ownership, 401K, health benefits, a great work environment and the opportunity to enter a high-growth startup company. We are recruiting candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of tackling challenging technical problems.&lt;/p&gt;
&lt;p&gt;&lt;em&gt;This position may be subject to pre-employment checks, including driving history check, drug screening and a background check for any convictions directly related to its duties and responsibilities. All pre-employment checks will comply with all applicable federal, state, and local laws.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;WE ARE AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION EMPLOYER&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Vizgen affords equal employment opportunity to all qualified persons regardless of race, color, religious creed, national origin, age, military status, sexual orientation, disability, genetic information, gender identity, gender expression or gender unless based upon a bona fide occupational qualification.&lt;/p&gt;&lt;/div&gt;

Senior Bioinformatics Applications Scientist 

&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA™ (eRNA), is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is long lasting, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery.&lt;/p&gt;
&lt;p&gt;Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform. There is a broad pipeline across therapeutic categories with the goal of 100 medicines in 10 years. To learn more, please visit the company’s website at https://www.laronde.bio/about.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Position:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking an experienced and driven data engineer who shares our vision of data as a strategic asset in enabling cutting-edge research. In this role you will design and develop cloud-based solutions to advance our goals by ensuring that the data that drives our science is Findable, Accessible, Interoperable, and Reusable. The ideal candidate will have a background working with life science organizations, experience with a variety of scientific data types, and expertise in cloud computing. It’s also essential to be a strong data modeler and coder, with an exceptional ability to deliver near-term value while helping companies plan for the future.&lt;/p&gt;
&lt;p&gt;The successful candidate will act as the glue between wet and dry labs within the company, ensuring that digital solutions meet the needs of bench scientists, computational/data/ML scientists and senior management while aligning with long term strategic objectives. As an early member of a privately held, well-funded, early-stage platform biotechnology company, you will have an opportunity to contribute to building our digital strategy and have significant influence on technology platform development, with many options to apply your skills and talent as the company continues to expand.&lt;/p&gt;
&lt;p&gt;This role is based at our Somerville, MA site. Role can be hybrid onsite 2-3 days per week.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Specific Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Create and maintain process maps of all the ways data accumulates and flows into and throughout the company&lt;/li&gt;
&lt;li&gt;Create automated pipelines for various workloads, including raw instrument data processing, computational workflows, and information reporting&lt;/li&gt;
&lt;li&gt;Organize and manage all structured and unstructured scientific data used by the company&lt;/li&gt;
&lt;li&gt;Design data models for entities, assays, and results from scientific experiments and analyses&lt;/li&gt;
&lt;li&gt;Drive consensus and implement standards around scientific research metadata&lt;/li&gt;
&lt;li&gt;Implement scalable, cloud-based solutions to support dramatic increases in data and analysis demands&lt;/li&gt;
&lt;li&gt;Integrate data and metadata from a variety of internal and external sources&lt;/li&gt;
&lt;li&gt;Deliver data products and visualizations to stakeholders&lt;/li&gt;
&lt;li&gt;Establish engineering standards around languages, DevOps and Agile project management&lt;/li&gt;
&lt;li&gt;Assist in the management and administration of our AWS environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Minimum Qualifications &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;MS degree (or BS with equivalent experience) in Bioinformatics, Informatics, Computer Science, Data Science or other related discipline&lt;/li&gt;
&lt;li&gt;3+ years’ experience in data engineering/research informatics in the life sciences&lt;/li&gt;
&lt;li&gt;Demonstrated proficiency with cloud development (AWS strongly preferred) using infrastructure-as-code frameworks&lt;/li&gt;
&lt;li&gt;Proficiency in with modeling and using data stored in relational and NoSQL databases&lt;/li&gt;
&lt;li&gt;Experience integrating multi-omic datasets&lt;/li&gt;
&lt;li&gt;Experience building processes supporting data transformation, data structures, metadata, dependency, and workload management&lt;/li&gt;
&lt;li&gt;Strong DevOps, project management and organization skills&lt;/li&gt;
&lt;li&gt;A people person with an exceptional ability to collaborate with scientists of different backgrounds&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with workflow orchestration software (Nextflow, SnakeMake, etc) and deploying it in cloud environments such as AWS Batch&lt;/li&gt;
&lt;li&gt;Experience with ELN/LIMS (Benchling preferred)&lt;/li&gt;
&lt;li&gt;Experience supporting and working with cross-functional teams in a fast-paced environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;em&gt;Laronde is &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;&lt;/em&gt;&lt;em&gt;: Laronde does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Laronde or its employees is strictly prohibited unless contacted directly by Laronde’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Laronde, and Laronde will not owe any referral or other fees with respect thereto&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Data Engineer / Senior Data Engineer

&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?&lt;/p&gt;
&lt;p&gt;Flagship Pioneering&#x27;s venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12thglobally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Company:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL86, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Drive and generate proof of concept data in cell-based and pharmacology models aimed at establishing the translational science of FL86 mosaics genetics&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and apply novel disease specific cell-based and in vivo pharmacological models to generate robust data package leading towards go/no go decisions&lt;/li&gt;
&lt;li&gt;Execute cell-based assays to assess intracellular signaling pathways, the biological activity of small molecules and biologics in disease relevant tissue specific cells&lt;/li&gt;
&lt;li&gt;Conduct proof of concept translational studies in primary tissues (fresh and fixed) to confirm target rationale, target engagement and biological response&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;B.S./M.S. in cell biology, molecular biology, pharmacology or similar technical fields&lt;/li&gt;
&lt;li&gt;3-5 years of experience in a biotech or pharmaceutical company (the title will be adjusted for the level of experience)&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience in mammalian cell culture including primary cells&lt;/li&gt;
&lt;li&gt;Experience in translational models, e.g., precision cut slices is a plus&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated&lt;/li&gt;
&lt;li&gt;Experience with the following techniques is highly preferred: Northern and Western blotting, RT-qPCR, RNA-seq, cloning, cell culture, immunohistochemistry&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Attributes:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Cell biologist with pharmacology background&lt;/li&gt;
&lt;/ul&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&lt;strong&gt;Location:&lt;/strong&gt; Cambridge, MA&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;

Sr. Research Associate/Associate Scientist, Cell Biology 

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first redosable and targetable DNA medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.&lt;br&gt;&lt;br&gt;Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ: MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The&amp;nbsp;Scientist/Sr. Scientist in Analytical Development of Technical Operations team supports multiple preclinical and early development phase platforms with advanced separation and biophysics technologies. The successful candidate will be a subject matter expert and key contributor to a highly technical, diverse, and collaborative team of scientists and engineers. The position offers the opportunity to interface with Process Development, Quality Control, Manufacturing, Regulatory, and external research institutes, and contract development manufacturing organizations. We are searching for an innovative, independent, and motivated scientist with high level of scientific curiosity and critical thinking to join our team and contribute to various aspects of the platform research and development.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and qualify analytical/biophysical assays related to purity, empty/full ratio, and physical/chemical properties to support viral vector testing and characterization. Techniques include SEC-MALS, CE-SDS, cIEF, AUC, and mass photometry.&lt;/li&gt;
&lt;li&gt;Planning, designing, and conducting the experiments and data analysis to support development and qualification of analytical/biophysical methods, generation, and interpretation of high-quality data.&lt;/li&gt;
&lt;li&gt;Author, review and/or approve technical documents (protocols, reports, test methods, etc) or regulatory filings ensuring high technical standards and compliance with applicable regulatory guidelines to support analytical/biophysical methods.&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Collaborate with process development team members to ensure timely delivery of high-quality data of routine analytical testing.&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Be a technical resource for junior staff and use expertise in laboratory technology as a functional resource/trainer.&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Understand project timelines and deliverables and plan/prioritize project work with departmental, functional, and external stakeholders to support multiple programs.&lt;/li&gt;
&lt;li&gt;Represent biophysics team to provide project update and advice to cross-functional teams and contribute scientific insights into multiple platforms.&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Participate analytical working group meetings to evaluate analytical strategy and implement new technologies related to analytical/biophysical methods.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD degree in analytical chemistry, biophysics, or related field 0+ years relevant industry experience for Scientist position, and 3+ years of relevant industry experience for Sr. Scientist position.&lt;/li&gt;
&lt;li&gt;Master’s degree in analytical chemistry, biophysics, or related field with 3+ years relevant industry experience for Scientist position, and minimum 6+ of relevant industry experience for Sr. Scientist position.&lt;/li&gt;
&lt;li&gt;Experience working with biotherapeutics, viral vector, and payload is preferred. Experience managing research associate is preferred for Sr. Scientist position.&lt;/li&gt;
&lt;li&gt;Demonstrated expertise developing separation and biophysical methods (eg. CE, cIEF, HPLC, sub-vis particle, AUC, and Octet protein binding assays) is essentially preferred&lt;/li&gt;
&lt;li&gt;Demonstrated hands-on experiences with Sciex PA800 Plus, Protein Simple Maurice, Wyatt MALS, and Agilent 1260 HPLC.&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Experience in analytical assay development, qualification, and tech transfer to comply with current regulatory standards is preferred.&lt;/li&gt;
&lt;li&gt;Author and review technical documents such as protocols, reports, internal presentations, method development and qualification reports.&lt;/li&gt;
&lt;li&gt;Proven record of technical expertise and ability to gain in-depth understanding of new technologies and scientific concepts. Independently design and implement scientifically sound and creative solutions.&lt;/li&gt;
&lt;li&gt;Understanding of project timelines and deliverables and plan and coordinate project work with departmental and cross functional peers (process development and QC).&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Excellent communication skills and ability to work effectively both independently and in a collaborative cross-functional environment with internal and external partners is essential&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Ability to work in a fast-paced, startup environment with demonstrated capacity to multi-task and independently prepare, execute, and document lab experiments.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;/div&gt;

Scientist/Sr. Scientist, Analytical development, Biophysics

&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?&lt;/p&gt;
&lt;p&gt;Flagship Pioneering&#x27;s venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12thglobally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Company:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL86, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Responsible for the translational validation of discovery platform targets in cell-based and in disease-relevant pharmacological models&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;The successful candidate will work both independently and as part of a team to design, plan and execute high-quality biochemical, cell-based and translational assays&lt;/li&gt;
&lt;li&gt;Lead the development and execution of cell-based assays to assess biological signaling pathways, the biological activity of small molecules, biologics or nucleotide-based compounds&lt;/li&gt;
&lt;li&gt;Define tissue and disease-specific target engagement levels, establish, and run biomarker plans and translational PK/PD assessment&lt;/li&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Mentor and train research associates as needed&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Bioengineering or related discipline with &amp;gt; 5 years of experience in a biotech or pharmaceutical company (the title will be adjusted for the level of experience)&lt;/li&gt;
&lt;li&gt;Deep knowledge and understanding of cell biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience in mammalian cell culture including primary cells and in handling tissues&lt;/li&gt;
&lt;li&gt;The ideal candidate has previous experience in RNA biochemistry and structural biology, cell-based genetic manipulations (e.g., siRNA, ASO) and RNA/DNA delivery&lt;/li&gt;
&lt;li&gt;Experience in the following techniques is a plus: FACS, RT-qPCR, RNA-seq, cloning, cell culture, IHC and quantitative image analysis, Meso Scale Discovery, HALO image analysis software.&lt;/li&gt;
&lt;li&gt;Strong written and oral presentation skills&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Attributes:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with translational cell-based and pharmacology models&amp;nbsp;&lt;/li&gt;
&lt;/ul&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&lt;strong&gt;Location:&lt;/strong&gt; Cambridge, MA&amp;nbsp;&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
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&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;

Data Scientist Jobs in Cambridge