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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/div&gt;
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&lt;p&gt;Laronde&amp;nbsp;is pioneering a platform that offers a novel way of modulating human biology. Endless RNA™ (eRNA) is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is long lasting, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery.&lt;/p&gt;
&lt;p&gt;Laronde&amp;nbsp;was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform. There is a broad pipeline of programs across therapeutic categories with the goal of 100 medicines in 10 years. To learn more, please visit the company’s website at https://www.laronde.bio/about.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is seeking an outstanding Bioinformatics Scientist at the Scientist or Senior Scientist level to join a multidisciplinary team of experimental and computational synthetic biologists and engineers responsible for study, design and optimization of novel endless RNA (eRNA) therapeutics. The ideal candidate will have experience in analysis, interpretation and method development of diverse Next Generation Sequencing (NGS) data, especially pertaining to analysis of RNA, and a high degree of proficiency in Python and experience in collaborative software development including git version control and test-driven development. The candidate will work as part of a team of bioinformaticians and will develop bioinformatics tools and pipelines to support both custom and standard NGS data analysis. If you are passionate about your work and want to contribute to the cutting-edge RNA therapeutics, we are looking for you.&lt;/p&gt;
&lt;p&gt;This role will be based at our 101 South Street Sommerville, MA site. There is flexibility to work from home 1-2 days per week.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and implement robust customized data processing pipelines for various NGS data including single-cell RNA-seq, ribosome profiling, and SHAPE-MaP.&lt;/li&gt;
&lt;li&gt;Perform custom analysis and report generation of large, complex datasets from a variety of experimental assays.&lt;/li&gt;
&lt;li&gt;Write documentations and tests for the bioinformatics tools and pipelines developed.&lt;/li&gt;
&lt;li&gt;Work closely with the lead bioinformatician and other scientists&lt;/li&gt;
&lt;li&gt;Maintain scientific and technical expertise through familiarity with scientific literature&lt;/li&gt;
&lt;li&gt;Work within an entrepreneurial, highly-collaborative, interdisciplinary, and fast-paced environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PHD in bioinformatics, computational biology or genomics with expertise in RNA biology or Masters experience with industry experience&lt;/li&gt;
&lt;li&gt;Broad range of current bioinformatics and computational biology tools, methods, and applications&lt;/li&gt;
&lt;li&gt;Knowledge of molecular biology, especially as related to translatable RNA&lt;/li&gt;
&lt;li&gt;Excellent analytical and programming skills&lt;/li&gt;
&lt;li&gt;Knowledge and experience of best-practice software development, including version control, unit and integration testing, documentation, and deployment&lt;/li&gt;
&lt;li&gt;GitHub repositories and publications that can showcase your skills&lt;/li&gt;
&lt;li&gt;Excellent communication and time management skills&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Bioinformatics Scientist / Senior Scientist

&lt;p&gt;&lt;strong&gt;Company Details:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL92/93 Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative RNA-based therapeutic approach.&lt;/p&gt;
&lt;p&gt;FL92/93 was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 100 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (NASDAQ:MRNA), Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics (NASDAQ:RUBY), Axcella Health (NASDAQ:AXLA), Evelo Biosciences (NASDAQ:EVLO), Laronde, Tessera, Alltrna, and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;F92/93 Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional RNA scientist to join our development team. FL92/93 is seeking a scientist (or senior scientist) with a strong background in nucleic acid manipulation and delivery strategies to join our expanding team as a part of our development group. The position requires broad technical experience that spans molecular biology, synthetic biology, and biophysics, with a strong emphasis on critical thinking, multitasking, and the ability to learn new techniques. The successful candidate will help lead and support multidisciplinary project teams focused on the engineering and development of new therapeutic modalities, including nucleic acids, peptides, proteins, cells, and various conjugate molecules. The candidate will focus on all aspects of development spanning conceptualization, experimentation, data analysis, presentation, and strategic planning.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Nucleic acid manipulation, modification, and analytic approaches&lt;/li&gt;
&lt;li&gt;Viral and non-viral nucleic acid formulation and delivery&lt;/li&gt;
&lt;li&gt;Quantitative analysis of biological molecules&lt;/li&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Written and oral presentation of results&lt;/li&gt;
&lt;li&gt;Manage and oversee CROs, providing technical expertise and direction on production and characterization activities&lt;/li&gt;
&lt;li&gt;Generate and support intellectual property generation for core projects&lt;/li&gt;
&lt;li&gt;Mentor and train research associates as needed&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Minimum Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Molecular Biology, Biochemistry, Bioengineering or related discipline&lt;/li&gt;
&lt;li&gt;Deep knowledge and understanding of RNA biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation&lt;/li&gt;
&lt;li&gt;Skilled in assay development and optimization of nucleic acid production, purification and biophysical characterization&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated&lt;/li&gt;
&lt;li&gt;Experience with the following techniques is highly preferred: RT-qPCR, RNA-seq, cloning, cell culture, immunohistochemistry, ELISA, ChIP, EMSA, FISH, Northern and Western blotting&lt;/li&gt;
&lt;/ul&gt;

FL92/93: (Sr) Scientist – RNA Biology

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as &amp;gt;95% of global healthcare costs are spent on treating rather than preventing chronic diseases. FL84, Inc. is a privately held early-stage company that is applying advanced biological and computational platforms to discover breakthroughs in detection of and intervention against the etiologies that drive progression from health to disease. Our goal is to leverage our proprietary platforms to disrupt the current approach of treating chronic disease too late. We endeavor to provide true health care rather than sick care to individuals that are at risk of progressing to disease.&lt;/p&gt;
&lt;p&gt;FL84 was founded by Flagship Pioneering, an innovation enterprise dedicated to originating and developing first-in-category life sciences companies. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a &lt;strong&gt;Health Data Scientist/Sr. Scientist&lt;/strong&gt; who is enthusiastic about developing, learning and&amp;nbsp;applying computational skills to understand complex clinical trajectories from health to disease. The role will include significant hands-on analyses of clinical data such as electronic health records, insurance claims, laboratory measurements, images, free text, and genetic data. The ideal candidate will be able to span across a wide variety of data types to craft a cohesive analysis of the trajectory of chronic disease progression. The candidate will work closely with the computational biology team to develop insights and novel prediction platforms for different stages of the journey from health to disease.&amp;nbsp; An ideal candidate will pride themselves on their ability to craft scientifically logical stories out of complex data and convert them into creative, executable experiments. The position will provide a unique opportunity to play a foundational role in the development of FL84’s preclinical platform.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work with FL84 team to develop and apply novel ML models on clinical data (EHR, insurance claims, labs, imaging, narrative notes, etc.)&lt;/li&gt;
&lt;li&gt;Develop prediction algorithms to detect with reasonably high success individuals before major changes in their health and forecast their time to detectable transition&lt;/li&gt;
&lt;li&gt;Ideate on how to align time-series biological data with clinically relevant inflection points identified in electronic health records, clinical trials, or other sources&lt;/li&gt;
&lt;li&gt;Identify and explore internal and external clinical datasets to address questions critical to FL84’s core objectives and generate testable hypotheses&lt;/li&gt;
&lt;li&gt;Develop clear, intuitive visualizations and communicate analysis results via presentations to a multi-disciplinary audience&lt;/li&gt;
&lt;li&gt;Cultivate a data-centric and process-oriented company philosophy by helping to maintain best practices for software development, data management, and infrastructure&lt;/li&gt;
&lt;li&gt;Monitor and evaluate new and emerging technologies and models and identify opportunities for collaboration within Flagship Pioneering companies, academia, and third parties&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD with 3+ years of experience or equivalent level of experience in applying machine learning/artificial intelligence to large-scale clinical data.&amp;nbsp; PhD may be in Biomedical Informatics, Bioinformatics, Machine Learning, Statistics, Computer Science, Data Science, Mathematics, or similar technical fields&lt;/li&gt;
&lt;li&gt;Demonstrated experience applying deep learning models to electronic health record or administrative claims data&lt;/li&gt;
&lt;li&gt;Contributions to analyses leveraging both clinical and genomic data&lt;/li&gt;
&lt;li&gt;Fluency in Python and experience with R and SQL&lt;/li&gt;
&lt;li&gt;Familiarity with common machine-learning/deep-learning packages such as scikit-learn, TensorFlow and PyTorch&lt;/li&gt;
&lt;li&gt;Familiarity with AWS, GCP, or similar cloud-computing services&lt;/li&gt;
&lt;li&gt;Ability to thrive in an entrepreneurial and multidisciplinary environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Requirements&lt;em&gt;:&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience in one or more of the following areas/topics: regression models, regularization, time-series models, recurrent neural networks, graph neural networks, LSTMs, NLP or CNNs&lt;/li&gt;
&lt;li&gt;Experience developing forecasting algorithms for time-series data&lt;/li&gt;
&lt;li&gt;Experience working with reference genetic and other biological databases and datasets (e.g., UK Biobank, TCGA, CMAP, LINCS) is a strong plus&lt;/li&gt;
&lt;li&gt;Experience running genome wide association studies (GWAS)&lt;/li&gt;
&lt;li&gt;Ability to Google error messages and seek resolution from self-investigation&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering is committed to&amp;nbsp;&lt;strong&gt;equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp;Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;/div&gt;

FL84: Scientist/Sr. Scientist, Health Data 

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&lt;p&gt;&lt;strong&gt;Company Summary:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first re-dosable and targetable genetic medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.&lt;br&gt;&lt;br&gt;Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health, Evelo Biosciences (EVLO), and Indigo Agriculture.&lt;br&gt;&lt;br&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The in vitro biology group at Ring Therapeutics is seeking to add a talented stem cell biologist at the Scientist I, Scientist II, or Senior Scientist level (position will be determined by experience).&amp;nbsp; Most importantly, the successful candidate will be a consummate teammate who will complement and help the group achieve success by working closely with others inside and outside the group.&amp;nbsp; The successful candidate will be responsible for generating IPSC/ESC derived 2D and 3D human retinal cultures and assays. &amp;nbsp;The cell cultures will then be used for the conceptualization, characterization, and optimization of engineered therapeutic proteins and their vectors.&amp;nbsp; The candidate will participate in the design and execution of in vitro cell biology experiments, including data analysis and communication.&amp;nbsp; The candidate will collaborate regularly with teams carrying out payload/protein engineering, vector engineering, and in vivo biology.&amp;nbsp; This is a great opportunity to participate in the development of cutting-edge gene therapy products. We are searching for highly collaborative, enthusiastic, and motivated individuals who are comfortable multitasking and working both within a team and independently on various aspects of the viral platform development.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;IPSC cell maintenance and design and execute 2D and 3D IPSC retinal differentiation strategies&lt;/li&gt;
&lt;li&gt;Develop and execute assays in support of our retinal biology programs&lt;/li&gt;
&lt;li&gt;Maintain various primary, IPSC-derived, and cell lines for routine assay work&lt;/li&gt;
&lt;li&gt;Coordinate experiments with other scientists across functional teams&lt;/li&gt;
&lt;li&gt;Use cell-based assays to help characterize new viral vectors and therapeutic proteins in vitro&lt;/li&gt;
&lt;li&gt;Help study the molecular and cell biology relevant to Ring’s Anellovectors&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Must be self-motivated, scientifically rigorous, and accustomed to effectively communicating progress, needs, and problems&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Great teammate with a desire to see his or her colleagues flourish&lt;/li&gt;
&lt;li&gt;PhD in cell and molecular biology, or closely related field&lt;/li&gt;
&lt;li&gt;2-5 years of IPSC and retina experience, in academic, pharmaceutical, or biotechnology settings. Industry experience preferred.&lt;/li&gt;
&lt;li&gt;Experience with&lt;/li&gt;
&lt;ul&gt;
&lt;li&gt;the visual system&lt;/li&gt;
&lt;li&gt;differentiated primary cell culture systems, 2D or 3D organoids, iPSC differentiation protocols, or organ-on-a-chip technology, etc,&lt;/li&gt;
&lt;li&gt;assay development, especially using primary or IPS cells or other human cell lines&lt;/li&gt;
&lt;li&gt;molecular biology and recombinant DNA techniques like gene editing and NGS desirable&lt;/li&gt;
&lt;li&gt;Confocal microscopy, light sheet microscopy, and other imaging techniques desirable&lt;/li&gt;
&lt;li&gt;use of viral vectors for gene delivery and therapy&lt;/li&gt;
&lt;/ul&gt;
&lt;li&gt;Demonstrated ability to work with highly skilled teams in a fast-paced, entrepreneurial, and technical environment.&lt;/li&gt;
&lt;li&gt;Good communication skills, capable of conveying technical information in a clear and thorough manner.&lt;/li&gt;
&lt;li&gt;Comfortable delivering against challenging commitments.&lt;/li&gt;
&lt;li&gt;Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;/div&gt;

Retinal Stem Cell Scientist I / Scientist II /  Senior Scientist, in vitro Biology

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&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt;you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?&lt;/p&gt;
&lt;p&gt;The people who work in the Flagship ecosystem are bright and bold, passionate, dynamic, and driven. We are creative optimists. We collaborate, iterate, tolerate failure, and celebrate successful solutions to big problems. We encourage diversity and debate because we value the freedom to explore unconventional ideas in order to cultivate revolutionary breakthroughs in science and business&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking individuals who are enthusiastic about developing, learning, and applying computational skills to join our passionate team of scientists. The Research Associate/Senior Research Associate positions will execute and contribute to building computational analysis pipelines, to derive insights from data, and help guide experimental design.&lt;/p&gt;
&lt;p&gt;Successful candidates will be self-starters, able to thrive in a fast-paced, action-oriented team environment and display a clear passion for science and impact. The individual will have demonstrated evidence of agility and nimbleness to progress scientific discoveries, and an overt attitude of positivity when facing challenges. The candidate will be dedicated to develop and grow outside their comfort zone by constantly learning.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities may include:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Learn, maintain, and execute computational pipelines for guiding experimental design, and analyzing next-generation sequencing data&lt;/li&gt;
&lt;li&gt;Support development and application of bioinformatics, computational biology, and machine learning tools to&lt;em&gt;generate&amp;nbsp;&lt;/em&gt;insights and hypotheses from high-dimensional molecular datasets, with an initial focus on time-series sc/snRNA-seq and genomic data&lt;/li&gt;
&lt;li&gt;Work with teams to develop and apply novel ML models on clinical data&lt;/li&gt;
&lt;li&gt;Extract information from literature and large public databases for predictive model refinement and real-world applications&lt;/li&gt;
&lt;li&gt;Write code to automate computational workflows&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS or MS in computer science, math, bioinformatics, or related disciplines&lt;/li&gt;
&lt;li&gt;For RA positions minimum BS and one year relevant experience OR MS with 1-3 years of relevant experience, for SRA minimum 3+ years of experience&lt;/li&gt;
&lt;li&gt;Proficiency programming in Python. Experience with R is a plus&lt;/li&gt;
&lt;li&gt;Familiarity with some of the following: molecular biology concepts, NGS, Linux, AWS, Jupyter&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
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&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.&amp;nbsp; The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.&amp;nbsp;&amp;nbsp; Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Research Associate, Computational Biology

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&lt;p&gt;&lt;strong&gt;The Company:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of deterministic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and therapeutics that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!&lt;/p&gt;
&lt;p&gt;Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Position:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking creative, curious, and resourceful team members who operate at the frontiers of engineering, biology, and drug discovery. This role would be responsible for crafting libraries of DNA, protein, and engineered cell constructs, and will have a substantial impact on the future success of Generate’s pipeline of biomedicines. This is a hands-on, laboratory-based position with a large opportunity for creativity and influence towards the direction of a rapidly growing science and technology company.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Design and build large, defined and/or combinatorial libraries&lt;/li&gt;
&lt;li&gt;Design and build components for designed biomolecular properties and cellular logic&lt;/li&gt;
&lt;li&gt;Bring a massive-throughput, automation-first mindset to DNA construction&lt;/li&gt;
&lt;li&gt;Partner with data scientists and engineers to apply machine learning to the generation of new biomedicines including antibodies, cell therapies, and gene therapies&lt;/li&gt;
&lt;li&gt;Work in dynamic, diverse, project-based teams in a flat hierarchy&lt;/li&gt;
&lt;li&gt;Actively contribute to the creation and development of new projects&lt;/li&gt;
&lt;li&gt;Serve as a leader and mentor in your field of expertise&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Working at Generate, you would have access to world-leading technology platforms in the areas of:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Automated liquid handling and digital microfluidics&lt;/li&gt;
&lt;li&gt;Droplet microfluidics for molecular and cell biology&lt;/li&gt;
&lt;li&gt;High-throughput cell- and protein-based library generation and screening&lt;/li&gt;
&lt;li&gt;Closed-loop machine learning/wetlab integration&lt;/li&gt;
&lt;li&gt;Protein structure/function prediction and determination&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;:&lt;/p&gt;
&lt;p&gt;We have multiple openings and are interested in candidates at various experience levels.&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Candidates with a bachelor’s degree, master’s degree, or doctorate degree (or equivalent professional experience) will be considered&lt;/li&gt;
&lt;li&gt;Experience designing and constructing large DNA libraries required&lt;/li&gt;
&lt;li&gt;Experience designing and constructing large cell-based discovery libraries strongly preferred&lt;/li&gt;
&lt;li&gt;Experience in a lab automation environment strongly preferred&lt;/li&gt;
&lt;li&gt;High-throughput (HTS) library generation and screening experience strongly preferred&lt;/li&gt;
&lt;li&gt;Familiarity with bioinformatic analyses with Python or R strongly desired but not required&lt;/li&gt;
&lt;li&gt;Closed-loop machine learning experience desired but not required&lt;/li&gt;
&lt;li&gt;Immuno-oncology or immunology experience desired but not required&lt;/li&gt;
&lt;li&gt;Ability to work in a dynamic, creative and fast-paced environment required&lt;/li&gt;
&lt;li&gt;Strong collaboration and communication skills required&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Important COVID-19 Guidance&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Generate Biomedicines has a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated, including having received a booster. In accordance with our duty to provide and maintain a workplace that is free of known hazards, this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations. &lt;/em&gt;&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Scientist/Sr Scientist/Pr Scientist, Enzyme Biochemistry and Protein Engineering

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&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;About Laronde&lt;/u&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA™ (eRNA), is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is long lasting, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery.&lt;/p&gt;
&lt;p&gt;Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform. There is a broad pipeline of programs across therapeutic categories with the goal of 100 medicines in 10 years. To learn more, please visit the company’s website at https://www.laronde.bio/about.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Position Summary&lt;/u&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are looking for a creative, energetic Scientist to join our team as a Cell Biologist in the Discovery Technologies team. The position requires extensive experience in tissue dissociation, FACS, and immunohistochemistry. The successful candidate will have a deep drive to learn and to collaborate. In this position you’ll be part of an energizing and supportive culture engaged in continuous learning.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Key responsibilities&lt;/u&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Drive research to identify and characterize eRNA-targeted cells &lt;em&gt;in vivo&lt;/em&gt;&lt;/li&gt;
&lt;li&gt;Interrogate single cells following by tissue dissociation and flow cytometry/FACS&lt;/li&gt;
&lt;li&gt;Analyze target tissues by IHC/IF, including RNA interrogation by FISH/RNA scope&lt;/li&gt;
&lt;li&gt;Develop cell assays to monitor target cell state and function&lt;/li&gt;
&lt;li&gt;Analyze data and present results to the team and in company-wide meetings&lt;/li&gt;
&lt;li&gt;Work closely with cross-functional teams to advance our platform and preclinical programs&lt;/li&gt;
&lt;li&gt;Contribute to other initiatives as they arise in our fast paced, startup environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Requirements&lt;/u&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in cell biology, immunology or a related field&lt;/li&gt;
&lt;li&gt;Deep experience in tissue dissociation and multi-parameter FACS&lt;/li&gt;
&lt;li&gt;Experience with IHC/IF staining, microscopy and automated image analysis&lt;/li&gt;
&lt;li&gt;Experience with molecular biology techniques including FISH and single cell RNAseq is preferred&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;Experience with RNA therapeutics and a good understanding of RNA biology is preferred&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li&gt;
&lt;ul&gt;
&lt;li&gt;Experience with image analysis and FACS software such as FlowJo, ImageJ, QuPath, GraphPad Prism&lt;/li&gt;
&lt;li&gt;Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial environment&lt;/li&gt;
&lt;li&gt;Excellent communication, scientific writing, and presentation skills&lt;/li&gt;
&lt;li&gt;Highly motivated, self-directed, with ability to multitask, prioritize work and manage several projects&lt;/li&gt;
&lt;/ul&gt;
&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Scientist – ex vivo Biology

&lt;p&gt;&lt;strong&gt;Company Details:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FLXX Inc. is a privately held, well-funded, early-stage biotechnology company that is pioneering a novel transformative RNA-based therapeutic approach.&lt;/p&gt;
&lt;p&gt;FLXX was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 100 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics, Seres Therapeutics (NASDAQ:MCRB), Syros Pharmaceuticals (NASDAQ:SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, Laronde, Tessera, Alltrna, and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;FLXX Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our development team. FLXX is&amp;nbsp;seeking a scientist with a strong background in nucleic acid manipulation and delivery strategies to join our expanding team as a part of our development group. The position requires broad technical experience that spans molecular biology, synthetic biology, and biophysics, with a strong emphasis on critical thinking, multitasking, and the ability to learn new techniques. The successful candidate will help lead and support multidisciplinary project teams focused on the engineering and development of new therapeutic modalities, including nucleic acids, peptides, proteins, cells, and various conjugate molecules. The candidate will focus on all aspects of development spanning conceptualization, experimentation, data analysis, presentation, and strategic planning.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Nucleic acid manipulation, modification, and analytic approaches&lt;/li&gt;
&lt;li&gt;Viral and non-viral nucleic acid formulation and delivery&lt;/li&gt;
&lt;li&gt;Mammalian cell culture&lt;/li&gt;
&lt;li&gt;Quantitative analysis of biological molecules&lt;/li&gt;
&lt;li&gt;Critical data analysis, attention to detail, and troubleshooting abilities&lt;/li&gt;
&lt;li&gt;Written and oral presentation of results&lt;/li&gt;
&lt;li&gt;Manage and oversee CROs, providing technical expertise and direction on production and characterization activities&lt;/li&gt;
&lt;li&gt;Manage research associates and scientists&lt;/li&gt;
&lt;li&gt;Generate and support intellectual property generation for core projects&lt;/li&gt;
&lt;li&gt;Mentor and train research associates as needed&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Minimum Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Molecular Biology, Biochemistry, Bioengineering or related discipline and 5+ years of industry experience&lt;/li&gt;
&lt;li&gt;Deep knowledge and understanding of RNA biology. Proficient in experimental design, assay execution, troubleshooting, data analysis, and data interpretation&lt;/li&gt;
&lt;li&gt;strong expertise in RNA biochemistry and RNA structural biology&lt;/li&gt;
&lt;li&gt;Skilled in assay development and optimization of nucleic acid production, purification and biophysical characterization&lt;/li&gt;
&lt;li&gt;Expertise in NGS library preparation, RNA seq and analysis of RNA binding protein interactions preferred&lt;/li&gt;
&lt;li&gt;Execution focused, team oriented, and highly motivated&lt;/li&gt;
&lt;li&gt;Experience with the following techniques is highly preferred: RT-qPCR, RNA-seq, cloning, cell culture, immunohistochemistry, ELISA, ChIP, EMSA, FISH, Northern and Western blotting&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Application instructions: Apply to Flagship Pioneering or reach out to the recruiter directly.&lt;/p&gt;
&lt;p&gt;LI#DG&amp;nbsp;&lt;/p&gt;

Stealth Flagship Labs: Principal Scientist – RNA Biology

&lt;p&gt;&lt;strong&gt;Scientist / Senior Scientist, In vitro Biology&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that is discovering and developing an entirely new class of medicines, one that leverages both chemistry and biology, to overcome many of the challenges faced by current therapeutics today?&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 83, Inc. (FL83) is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of a transformational new class of medicines, called Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt;, that is unlocked by novel synthetic and computational technologies. We seek an exceptional In Vitro Biologist to join our entrepreneurial and innovation-driven organization.&lt;/p&gt;
&lt;p&gt;FL83 was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position summary&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 83 is looking for a creative and motivated &lt;strong&gt;Scientist or Senior Scientist&lt;/strong&gt; to build our Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt; biology team. As part of the founding scientific team, this individual will be instrumental in building the biology platform, using in vitro studies to screen and characterize Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt; libraries, with the aim to develop impactful new therapeutics. This individual will have experience in peptide and protein discovery ideally including both molecular and cellular biology. A successful candidate will be an excellent collaborator working closely with our Computational Protein Design, and Platform Development teams to implement and execute rapid design-build-test iteration cycles and optimized methods.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Design and execute hit-to-lead&lt;em&gt; &lt;/em&gt;experiments for peptides, proteins, and biopolymer libraries (Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt;)&lt;/li&gt;
&lt;li&gt;Perform cellular/molecular biology techniques including immune, metabolic, enzymatic and signaling cell-based assays (eg. GPCR activation)&lt;/li&gt;
&lt;li&gt;Perform medium and high throughput assays including ELISA, SPR, FP, TR-FRET, and biopanning (i.e. phage display)&lt;/li&gt;
&lt;li&gt;Design, develop, optimize and execute in vitro assays such as Western blots, Coomassie blue staining, MSD, RT-PCR, qPCR, and flow cytometry, etc.&lt;/li&gt;
&lt;li&gt;Perform statistical analysis of results and prepare figures for discussion&lt;/li&gt;
&lt;li&gt;Document high quality results in an electronic laboratory notebook, and present and share with the broader team of scientists and leadership&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD or MS in cellular biology, molecular biology, immunology, neurobiology or related discipline, with 2-5+ years of industry research preferred&lt;/li&gt;
&lt;li&gt;Driven to develop a transformative therapeutic discovery and target validation platform&lt;/li&gt;
&lt;li&gt;Experience executing on various cell-based disease models across target disease areas (eg. DiscoverX assays)&lt;/li&gt;
&lt;li&gt;Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals and conference proceedings&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work with highly skilled, intellectually diverse teams in an industry environment&lt;/li&gt;
&lt;li&gt;Experience with receptor-ligand assays, signal transduction assays, and/or cytokine/chemokine/growth factor biology a plus&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;*: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.*&lt;/p&gt;

FL83: (Sr) Scientist, In Vitro Biology

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&lt;p&gt;&lt;strong&gt;What if…&lt;/strong&gt; you could join an organization that is discovering and developing an entirely new class of medicines, one that leverages both chemistry and biology, to overcome many of the challenges faced by current therapeutics today?&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 83, Inc. (FL83) is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of a transformational new class of medicines, called Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt;, that is unlocked by novel synthetic and computational technologies. We seek an exceptional In Vivo Biologist to join our entrepreneurial and innovation-driven organization.&lt;/p&gt;
&lt;p&gt;FL83 was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position summary&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Labs 83 is looking for a creative and motivated &lt;strong&gt;Scientist or Senior Scientist&lt;/strong&gt; to build our Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt; biology team. As part of the founding scientific team, this individual will be instrumental in building the biology platform, using in vivo studies to screen and characterize Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt; libraries, with the aim to develop impactful new therapeutics. This individual will have experience in peptide and protein discovery ideally including both molecular and cellular biology and conducting animal studies. A successful candidate will be an excellent collaborator working closely with our Computational Protein Design, and Platform Development teams to implement and execute rapid design-build-test iteration cycles and optimized methods.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Design and execute hit-to-lead&lt;em&gt; &lt;/em&gt;experiments for peptides, proteins, and biopolymer libraries (Artificial Biologics&lt;sup&gt;TM&lt;/sup&gt;)&lt;/li&gt;
&lt;li&gt;Manage rodent vivarium activities (both in-house and with CROs) including designing studies, performing drug administrations (eg. intravenous, intraocular, topical, oral), tissue collection and sample preparation&lt;/li&gt;
&lt;li&gt;Research, propose, and implement new disease models&lt;/li&gt;
&lt;li&gt;Prepare biological samples for downstream processing (affinity purification, SPE, LC-MS)&lt;/li&gt;
&lt;li&gt;Perform common molecular biology experiments including Western blots, ELISAs, and biochemical assays to support therapeutic development&lt;/li&gt;
&lt;li&gt;Maintain awareness of the landscape of in vivo studies of peptides and protein therapeutics and proactively research new techniques to refine and implement&lt;/li&gt;
&lt;li&gt;Perform statistical analysis of results and report findings at internal meetings&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD or MS in cellular biology, molecular biology, immunology, neurobiology or related discipline, with 2-5+ years of industry research preferred&lt;/li&gt;
&lt;li&gt;Driven to develop a transformative therapeutic discovery and target validation platform&lt;/li&gt;
&lt;li&gt;Experience executing on various animal and cell-based disease models across target disease areas&lt;/li&gt;
&lt;li&gt;Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals and conference proceedings&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner&lt;/li&gt;
&lt;li&gt;Confident execution, focused and team-oriented with an ability to thrive in an entrepreneurial environment&lt;/li&gt;
&lt;li&gt;Exposure to pre-clinical DMPK and toxicology studies is a plus&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt;&amp;nbsp;regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;*: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.*&lt;/p&gt;
&lt;/div&gt;

FL83: (Sr) Scientist, In Vivo Biology 

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA™ (eRNA), invented at Flagship Labs, is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is persistent, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery. Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform and a broad pipeline of programs across a number of therapeutic categories. To learn more, please visit the company’s website at https://www.laronde.bio/ .&lt;/p&gt;
&lt;p&gt;Laronde was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources and grows first-in-category life sciences companies. Since 2000, Flagship has created over 100 groundbreaking companies pioneering novel and proprietary biological, industrial and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (MRNA), Seres Therapeutics (MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Evelo Biosciences (EVLO), Kaleido Biosciences (KLDO) and Indigo Agriculture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Laronde is seeking a highly skilled and motivated Senior Research Associate/Associate Scientist to join our Analytical Development team.&amp;nbsp; The successful candidate will work alongside AD team members and contribute to our efforts to develop and implement methods for the eRNA platform. &amp;nbsp;The individual will contribute to advancement of our pipeline by collaboration with internal and external partners. In addition to technical expertise, the ideal candidate should also possess the ability to successfully interface with multidisciplinary teams. Candidates should be highly motivated, detail oriented and able to excel in a fast-moving environment.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Participate in the development, optimization, and troubleshooting of novel analytical methods&lt;/li&gt;
&lt;li&gt;Perform a variety of techniques to assess product quality and characterize eRNA products, including cell-based assays, immunoassays, and molecular biology techniques&lt;/li&gt;
&lt;li&gt;Deploy high throughput versions of methods to assess preclinical materials&lt;/li&gt;
&lt;li&gt;Perform data analysis and properly document experiments in the ELN system&lt;/li&gt;
&lt;li&gt;Author methods, protocols, and reports; assist with method transfer to vendor labs&lt;/li&gt;
&lt;li&gt;Effectively draw conclusions from data and present results at internal meetings&lt;/li&gt;
&lt;li&gt;Work with the process development team to characterize impact of process improvements&lt;/li&gt;
&lt;li&gt;Train and mentor junior colleagues&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS in Life Sciences, Chemistry, or related discipline&lt;/li&gt;
&lt;li&gt;A minimum of 5 with BS or 3 years related experience with MS&lt;/li&gt;
&lt;li&gt;Hands-on experience with mammalian cell culture and cell-based assays, ELISAs, and/or PCR; prior experience in an analytical development setting highly desirable&lt;/li&gt;
&lt;li&gt;Experience in maintaining a laboratory notebook and following protocols&lt;/li&gt;
&lt;li&gt;Desire and drive to learn and understand the biological mechanisms underpinning our eRNA products&lt;/li&gt;
&lt;li&gt;Highly organized team player with excellent oral and written communication skills&lt;/li&gt;
&lt;li&gt;Self-motivated, detail oriented, and ability to manage multiple laboratory activities&lt;/li&gt;
&lt;li&gt;Adaptable to a fast-paced environment with frequently changing priorities&lt;/li&gt;
&lt;/ul&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Senior Research Assistant / Associate Scientist, Analytical Development (Bioassay)

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;Machine Learning Scientist, Molecular Design&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Who We Are&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://www.flagshippioneering.com/&quot;&gt;Flagship Pioneering&lt;/a&gt;&amp;nbsp;conceives, resources, and builds companies across both human health and sustainability. Flagship has created over 100 scientific ventures resulting in &amp;gt;$200 billion in aggregate value, 500+ issued patents, and &amp;gt;50 clinical trials, spanning &lt;a href=&quot;https://www.modernatx.com/&quot;&gt;Moderna Therapeutics&lt;/a&gt;, &lt;a href=&quot;https://generatebiomedicines.com/&quot;&gt;Generate Biomedicines&lt;/a&gt;, &lt;a href=&quot;https://www.indigoag.com/&quot;&gt;Indigo Ag&lt;/a&gt;, &lt;a href=&quot;https://www.tesseratherapeutics.com/&quot;&gt;Tessera Therapeutics&lt;/a&gt;, and others. We harness science and entrepreneurialism to envision alternative futures, beginning with seemingly unreasonable propositions and navigating to transformational outcomes through an iterative, evolutionary methodology. We call this process&amp;nbsp;&lt;em&gt;“pioneering”.&lt;/em&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;We are looking for extraordinary computational scientists, engineers, and entrepreneurs to work alongside individuals within the Flagship Ecosystem focused on solving the most impactful challenges in AI across both human health and sustainability. We collaborate, encourage failure, trust one another, and celebrate successful solutions to hard problems. We respect the diversity of opinion - because we value the freedom to explore hunches.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We believe deep integration of data-driven machine learning with experimental approaches will be a core driver of the next generation of defining companies in health and sustainability. We aim to upend the traditional approach to molecular discovery towards one characterized by intentionality, programmability, and speed by developing methods for molecular design and generation that can reliably generalize across functions and applications. Modalities with potential across these applications span scientific areas across biology, chemistry, physics, materials science, and beyond; we believe that immense impact potential in human and sustainability can come from diverse scientific and machine learning backgrounds – and are open to all profiles with computational excellence.&lt;/p&gt;
&lt;p&gt;To this end, we are seeking creative, motivated Machine Learning Scientists to develop and apply our core technologies for ML-enabled molecular generation across various modalities spanning both health and sustainability applications. You will join companies and explorations at the early stages of our company creation process to develop innovative methods for molecular generation and modeling, leveraging both in-house and external data to train and evaluate models while also deploying new algorithms into production and integrating deeply into experimental platforms. The successful candidate will work closely with experimental scientists to rapidly advance various scientific programs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop novel machine learning models and algorithms for data-driven molecular design and hone them through deployment on experimental platforms.&lt;/li&gt;
&lt;li&gt;Advance and evaluate the state of the art for machine learning models connecting molecular forms, features, structures, and function, spanning applications such as design of sequence-based molecules, structure prediction, complex prediction, and function learning.&lt;/li&gt;
&lt;li&gt;Use our integrated data platform to devise models able to leverage measured labels “in-the-loop”.&lt;/li&gt;
&lt;li&gt;Work with experimental groups to tailor modeling efforts toward high-impact applications.&lt;/li&gt;
&lt;li&gt;Develop production-quality code in a team setting and plan for deploying and training models at scale.&lt;/li&gt;
&lt;li&gt;Present progress from scientific work in regular research meetings and prepare reports and slide decks for broader internal and external communication.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in a computer science, statistics, or a related field with demonstrated experience applying computational methods to scientific applications&lt;/li&gt;
&lt;li&gt;3+ years of experience with developing Machine Learning methods to solve scientific problems, with a particular interest towards applications to molecular generation as well as adjacent fields such as biology, chemistry, physics, materials science, immunology, or genomics&lt;/li&gt;
&lt;li&gt;Experience developing, debugging, and applying models using modern deep learning frameworks&lt;/li&gt;
&lt;li&gt;Proficiency in Python and machine learning frameworks such as Tensorflow, Pytorch, and/or JAX&lt;/li&gt;
&lt;li&gt;Energetic self-starter with the ability to work effectively in an entrepreneurial environment&lt;/li&gt;
&lt;li&gt;Excellent analytical skills and ability to synthesize &amp;amp; communicate complex information rapidly and effectively&lt;/li&gt;
&lt;li&gt;Unmatched sense of urgency&lt;/li&gt;
&lt;li&gt;A deep passion for using novel machine learning techniques to unlock new impact potential across health and/or sustainability&lt;/li&gt;
&lt;li&gt;No ego&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Foundational knowledge around probabilistic machine learning and optimization methods&lt;/li&gt;
&lt;li&gt;Practical experience developing deep generative models (e.g., autoregressive models, VAEs, Flows, GANs, EBMs, Transformers, etc.)&lt;/li&gt;
&lt;li&gt;Publications in major ML conferences or scientific journals that apply ML to problems in the sciences, including but not limited to molecular biology, chemistry, physics, materials science, structural biology, genetics, or other key questions that center around molecular prediction, design, and/or generation&lt;/li&gt;
&lt;li&gt;Demonstrated experience developing software in a team setting&lt;/li&gt;
&lt;li&gt;Experience with optimizing performant code&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Machine Learning Scientist, Molecular Design

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;Machine Learning Scientist, Molecular Design&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Who We Are&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://www.flagshippioneering.com/&quot;&gt;Flagship Pioneering&lt;/a&gt;&amp;nbsp;conceives, resources, and builds companies across both human health and sustainability. Flagship has created over 100 scientific ventures resulting in &amp;gt;$200 billion in aggregate value, 500+ issued patents, and &amp;gt;50 clinical trials, spanning &lt;a href=&quot;https://www.modernatx.com/&quot;&gt;Moderna Therapeutics&lt;/a&gt;, &lt;a href=&quot;https://generatebiomedicines.com/&quot;&gt;Generate Biomedicines&lt;/a&gt;, &lt;a href=&quot;https://www.indigoag.com/&quot;&gt;Indigo Ag&lt;/a&gt;, &lt;a href=&quot;https://www.tesseratherapeutics.com/&quot;&gt;Tessera Therapeutics&lt;/a&gt;, and others. We harness science and entrepreneurialism to envision alternative futures, beginning with seemingly unreasonable propositions and navigating to transformational outcomes through an iterative, evolutionary methodology. We call this process&amp;nbsp;&lt;em&gt;“pioneering”.&lt;/em&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;We are looking for extraordinary computational scientists, engineers, and entrepreneurs to work alongside individuals within the Flagship Ecosystem focused on solving the most impactful challenges in AI across both human health and sustainability. We collaborate, encourage failure, trust one another, and celebrate successful solutions to hard problems. We respect the diversity of opinion - because we value the freedom to explore hunches.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We believe deep integration of data-driven machine learning with experimental approaches will be a core driver of the next generation of defining companies in health and sustainability. We aim to upend the traditional approach to molecular discovery towards one characterized by intentionality, programmability, and speed by developing methods for self-driven experimental planning and optimization, especially where we are innovating new discovery-related and generative efforts in regimes that are highly data-sparse or where efficiency of data acquisition can be a key value driver. Modalities with potential across these applications span scientific areas across biology, chemistry, physics, materials science, and beyond; we believe that immense impact potential in human and sustainability can come from diverse scientific and machine learning backgrounds, and are open to all backgrounds with computational excellence.&lt;/p&gt;
&lt;p&gt;To this end, we are seeking creative, motivated Machine Learning Scientists to develop and apply our core technologies for ML-enabled Bayesian optimization, active learning, and experimental design. You will join companies and explorations at the early stages of our company creation process to develop innovative methods for optimal experiment planning and/or sequential design, deploying models and integrating them deeply into in-house experimental platforms and workflows. The successful candidate will work closely with experimental scientists to rapidly coordinate and advance various scientific programs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop novel machine learning models and algorithms for data-driven experimental design and hone them through deployment on experimental platforms for efficient sampling and data acquisition.&lt;/li&gt;
&lt;li&gt;Develop, advance, and evaluate the state of the art for machine learning methods for developing surrogate models and acquisition functions, spanning Gaussian processes and functions like maximum probability of improvement and expected improvement, as well as approaches based on deep learning, variational models, as well as other areas of continual innovation in the field.&lt;/li&gt;
&lt;li&gt;Use our integrated data platform to devise models able to direct measurements “in-the-loop”.&lt;/li&gt;
&lt;li&gt;Work with experimental groups to coordinate and structure experimental workflows and timelines and tailor efforts toward high-impact data sampling.&lt;/li&gt;
&lt;li&gt;Develop production-quality code in a team setting and plan for deploying and training models at scale.&lt;/li&gt;
&lt;li&gt;Present progress from scientific work in regular research meetings and prepare reports and slide decks for broader internal and external communication.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in a computer science, statistics, or a related field with demonstrated experience applying computational methods to scientific applications&lt;/li&gt;
&lt;li&gt;3+ years of experience with developing Machine Learning methods to solve scientific problems, with a particular interest towards applications to active learning, Bayesian optimization, and/or experimental design as well as adjacent fields such as biology, chemistry, physics, materials science, immunology, or genomics&lt;/li&gt;
&lt;li&gt;Foundational knowledge on Bayesian optimization and experimental planning methods including methods for uncertainty quantification and probabilistic modeling such as Gaussian processes, variational methods, MCMC techniques, and conformal prediction.&lt;/li&gt;
&lt;li&gt;Proficiency in Python and machine learning frameworks such as Tensorflow, Pytorch, and/or JAX&lt;/li&gt;
&lt;li&gt;Energetic self-starter with the ability to work effectively in an entrepreneurial environment&lt;/li&gt;
&lt;li&gt;Excellent analytical skills and ability to synthesize &amp;amp; communicate complex information rapidly and effectively&lt;/li&gt;
&lt;li&gt;A deep passion for developing novel machine learning techniques to unlock new impact potential across health and/or sustainability&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Practical experience developing and integrating Bayesian optimization or active learning into experimental workflows&lt;/li&gt;
&lt;li&gt;Publications in major ML conferences or scientific journals that apply ML to problems in the sciences, including but not limited to molecular biology, chemistry, physics, materials science, structural biology, genetics, or other key questions that center around experimental planning, uncertainty estimation, and/or broader online machine learning&lt;/li&gt;
&lt;li&gt;Demonstrated experience developing software in a team setting&lt;/li&gt;
&lt;li&gt;Experience with optimizing performant code&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are&amp;nbsp;&lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Machine Learning Scientist, Optimization 

&lt;p&gt;&lt;strong&gt;About Generate Biomedicines:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Generate Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. Generate has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.&lt;/p&gt;
&lt;p&gt;We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!&lt;/p&gt;
&lt;p&gt;Generate was founded in 2018 by Flagship Pioneering and has received over $420 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Cambridge, Somerville, and Andover with approximately 150 employees.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Role:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Generate Biomedicines&lt;/strong&gt; is looking for an exceptionally talented and highly motivated individual to join the growing &lt;strong&gt;Target Binding&lt;/strong&gt; team. The candidate will &lt;strong&gt;evaluate protein-protein interactions using a repertoire of biophysical, label-free platforms such as Biacore, Carterra and Octet&lt;/strong&gt; to better enable Generate Biomedicines’ machine learning-powered platform and rapidly advance biotherapeutics through the drug discovery pipeline. The position will focus on &lt;strong&gt;target validation, screening, assay optimization, binding kinetics and epitope binning&lt;/strong&gt;. The successful candidate will apply fundamental biomolecular interaction analysis principles to support data-driven, high-throughput and modality-agnostic workflows.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities may include but are not limited to:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform fit-for-purpose biosensor-based assays to characterize in vitro binding profiles of biotherapeutic candidates using surface plasmon resonance (SPR) and bio-layer interferometry (BLI) techniques with minimal supervision&lt;/li&gt;
&lt;li&gt;Employ liquid handling robotics and other high-throughput instrumentation&lt;/li&gt;
&lt;li&gt;Efficiently collate, analyze and visualize large data sets&lt;/li&gt;
&lt;li&gt;Pioneer efforts to integrate new technologies and innovative methodologies into preexisting workflows to expand our machine learning capabilities&lt;/li&gt;
&lt;li&gt;Collaborate with data scientists and multidisciplinary project teams to support critical decision-making checkpoints throughout discovery process&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;B.S./M.S./Ph.D in a science-related discipline with 6+ years (B.S./M.S.) or 0+ years (Ph.D.) of relevant research experience preferably in an industry setting&lt;/li&gt;
&lt;li&gt;Hands-on experience in investigating protein-protein interactions using one or more biosensor-based platforms (Carterra, Biacore, Octet) and/or orthogonal approaches (KinExA, MST, ELISA, MSD, Luminex)&lt;/li&gt;
&lt;li&gt;Demonstrated ability to design, perform, interpret and document experiments in a timely fashion&lt;/li&gt;
&lt;li&gt;Knowledge of common protein characterization techniques (SDS-PAGE, Western blotting, SEC, MS), is a plus&lt;/li&gt;
&lt;li&gt;Experience with liquid handling robotics, laboratory automation and scripting, is a plus&lt;/li&gt;
&lt;li&gt;Ability to thrive in a dynamic, highly collaborative and fast-paced environment with excellent communication and organizational skills is required&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Location&lt;/strong&gt;: Cambridge/Somerville&lt;/p&gt;
&lt;p&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;COVID Safety&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Generate Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster.&amp;nbsp; The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations.&amp;nbsp; The company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable law.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;

Associate Scientist / Scientist, Target Binding

&lt;div class=&quot;&quot; data-block=&quot;true&quot; data-editor=&quot;c12n7&quot; data-offset-key=&quot;dhkj5-0-0&quot;&gt;
&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Montai Health, a Flagship Pioneering Company, is a privately held, early-stage biotechnology company developing a platform for understanding and leveraging complex molecular interactions within organisms to solve global challenges in human health and sustainability. The company leverages a multidisciplinary approach that integrates tools ranging from machine learning and big data to multi-omics and high-throughput screening. Montai Health was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking to hire an innovative and highly motivated&lt;strong&gt;&amp;nbsp;Associate Scientist/Research Associate&lt;/strong&gt;&amp;nbsp;to join the Translational Biology Team at Montai Health in developing a transformative new category of molecular medicines. The candidate will be primarily responsible for conducting&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;immunological and pharmacological evaluations of test agents. Further, the candidate will assist in developing cell based and in vivo assays, flow cytometry analysis, and other immunological assays (ELISA, MSD, Luminex, ELISPOT). The successful candidate will also have a broad technique skill set, including in vitro and molecular biological techniques. This individual will be a key member of Montai Health’s dynamic, expanding, and collaborative team that combines significant experience in cellular biology, metabolism, chemistry, immunology, machine learning, molecular nutrition, and drug delivery.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities:&amp;nbsp;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work with senior research staff to design and execute experiments.&lt;/li&gt;
&lt;li&gt;Conduct&amp;nbsp;&lt;em&gt;in vivo&amp;nbsp;&lt;/em&gt;immunological and pharmacological animal experiments in rodents.&lt;/li&gt;
&lt;li&gt;Conduct&amp;nbsp;&lt;em&gt;ex vivo&lt;/em&gt;&amp;nbsp;plate/ tube-based experiments.&lt;/li&gt;
&lt;li&gt;Work closely and harmoniously with across Montai Health to drive exciting platform demonstrations and preclinical data packages.&lt;/li&gt;
&lt;li&gt;Contribute to scientific discussions regarding study design, implementations, and data analysis.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Required Skills/Experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;MS in a biology or engineering-related field with 3 year of biotech experience (or BS with 5 years plus of experience).&lt;/li&gt;
&lt;li&gt;Experience with rodent handling, dosing (PO, IV, SQ, IM, IP), bleeding (tail, submandibular and intracardiac), necropsy and tissue harvesting.&lt;/li&gt;
&lt;li&gt;Experience with multicolor flow cytometry and fluorescence-activated cell sorting.&lt;/li&gt;
&lt;li&gt;Experience with molecular assays: qPCR, electrophoresis, western blot and ELISA.&lt;/li&gt;
&lt;li&gt;Familiar with mammalian cell culture and aseptic technique.&lt;/li&gt;
&lt;li&gt;Familiar with IACUC and compliance requirements.&lt;/li&gt;
&lt;li&gt;Excellent verbal and written communication skills, strong organizational skills.&lt;/li&gt;
&lt;li&gt;Excellent documentation skills and familiarity with electronic notebook.&lt;/li&gt;
&lt;li&gt;Ability to work in a fast-paced and quickly changing environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Desired Skills/Experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Rodent &lt;em&gt;in vivo&lt;/em&gt; experience&lt;/li&gt;
&lt;li&gt;Fluorescent microscopy&lt;/li&gt;
&lt;li&gt;Flow cytometry&lt;/li&gt;
&lt;li&gt;Immunostaining&lt;/li&gt;
&lt;li&gt;Immunological assays&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Personal Characteristics:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Agility: Ability to work in a high energy organization with evolving goals and deliverables&lt;/li&gt;
&lt;li&gt;Results Oriented: Self-motivated, curious, accomplishes goals with minimal oversight&lt;/li&gt;
&lt;li&gt;Communication: Outstanding written and verbal communication skills, ability to work well with colleagues from diverse backgrounds and cultures&lt;/li&gt;
&lt;li&gt;Authenticity: Ability to voice their opinion and provide insight to the broader team, even when holding a minority or “out of the box” opinion. Ability to thrive with input from a cross-functional team while remaining the unquestioned scientific expert&lt;/li&gt;
&lt;li&gt;Team player: Desire to routinely interact with and mentor team members&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Location: &lt;/strong&gt;Cambridge, MA&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;More About Flagship Pioneering&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).&lt;/p&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;Flagship Pioneering and our ecosystem companies are &lt;strong&gt;committed to equal employment opportunity&lt;/strong&gt; regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.&lt;/div&gt;
&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;6ni4e-0-0&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;/div&gt;
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&lt;div class=&quot;public-DraftStyleDefault-block public-DraftStyleDefault-ltr&quot; data-offset-key=&quot;cpe78-0-0&quot;&gt;&lt;em&gt;&lt;strong&gt;Recruitment &amp;amp; Staffing Agencies&lt;/strong&gt;: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/div&gt;
&lt;/div&gt;
&lt;/div&gt;

Associate Scientist/Research Associate, Translational Biology 

&lt;div class=&quot;content-intro&quot;&gt;&lt;p&gt;&lt;strong&gt;About Inari...&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Inari is the SEEDesign™ company. We embrace the diversity and complexity of nature in every aspect of our business to drive innovation – to push the boundaries of what is possible. Through our unrivaled technology platform, Inari uses predictive design and advanced multiplex gene editing to develop step-change products. We are taking a nature positive approach to unlock the full potential of seed that will transform the food system. The results will lead to more productive acres delivering value creation for farmers and a more sustainable future for our planet.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Our success is dependent on great minds, collaborating to generate bright ideas and deliver exceptional outcomes.&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We have over 200 employees, with research sites in Cambridge, MA (USA) and Ghent (Belgium), as well as a product development site in West Lafayette, IN (USA). We’ve deliberately built a team that brings diversity of thought to all aspects of our business, to generate new ideas, approaches, and ways of operating. And we&#x27;ve intentionally combined experience with potential, bringing agriculture industry experts with the desire to innovate together with bright minds from academia, human therapeutics, software, and consulting. If you want to be part of a diverse and inclusive team developing unique solutions to feed the world while protecting our planet’s natural resources, we’d love to hear from you!&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&lt;strong&gt;About The Role….&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This is a great opportunity for a highly motivated and dedicated Computational Biologist to join our Data Analytics &amp;amp; Automation Team on the Science Platform to support the development of Inari’s multiplex genome editing toolbox, scientific projects, and product development. In this role, you will have the opportunity to engage in a cross-functional team as a computational biologist to perform statistical analysis, genomic and editing data analysis, and predictive modeling. The role is required to work closely and dynamically with other team members across both wet and dry sides to enable better editing designs and prediction of editing outcomes. If you are looking for a challenging opportunity in a fast-growing team environment, this role is for you. The role will be based in Cambridge, MA.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;As A Computational Biologist, You Will...&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Independently perform statistical analysis, genomic and editing data analysis, mine public databases, and predictive modeling to &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;provide scientific contributions and &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;achieve business goals&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Drive innovation and value by combining state-of-the-art analytics, data integration, data visualization, and biological domain knowledge&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and implement advanced models, including machine learning/deep learning, with applications to genomics and gene editing&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Partner with data science platform, engineers, and collaborators across domains to understand research and product development needs and deliver on high-impact projects and cross-function support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Communicate business impact accurately across key stakeholders and present validated results to all levels of the organization, including peers, senior management, and internal stakeholders to drive both strategic and operational service changes&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;You Bring…&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Required Qualifications:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ph.D. degree or equivalent experience in one of the following areas: Computational Biology, Statistical Genetics, Population Genetics, Biostatistics, Bioinformatics, Computer Science or other related quantitative disciplines&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with multi-omics data and managing and dissecting large unstructured datasets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Demonstrate strong data science skills and level of experience building data analysis pipeline, statistical models, and analyzing data using R and/or Python&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop heuristic rules, optimization, and algorithms to improve editing design and data analysis pipeline&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Proficiency in predictive modeling and broad understanding of emerging machine learning and deep learning approaches, limitations, and pitfalls&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with machine learning libraries like Scikit-learn, PyTorch, and/or TensorFlow for biological applications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ability to work independently and manage timelines in a fast-paced, collaborative and cross-functional environment and handle ambiguity gracefully&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Fast learner, critical thinking, can-do attitude, strong problem-solving skills, and agility to adapt approaches to new data and questions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong communication competencies to present computational concepts and explain your work to a wide variety of audiences across levels of the organization&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Additional Desired Skills/Experience:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with population genetics&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in applying machine learning algorithms to gene editing problems&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in creating web-based tools and visualization applications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A good understanding of gene editing&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A good understanding of pangenome&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Our Offer:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We offer you a challenging job in an exciting environment. You will be part of a growing and innovative company, driven by a strong purpose of transforming the plant breeding industry. You will be part of a multidisciplinary team and have the possibility to grow in your role through continuous learning. You will be challenged to take initiative, contributing to the success of the company. We offer you a competitive compensation package commensurate with your skill and experience.&lt;/span&gt;&lt;/p&gt;

Computational Biologist

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&lt;p&gt;&lt;strong&gt;Company Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;FL70, Inc is one of the latest companies founded through Flagship Pioneering’s venture creation engine, where companies such as&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Moderna&amp;nbsp;&lt;/em&gt;Therapeutics,&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Rubius&amp;nbsp;&lt;/em&gt;Therapeutics, and&lt;em class=&quot;Highlight&quot;&gt;&amp;nbsp;Evelo&amp;nbsp;&lt;/em&gt;Therapeutics were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of nearly 100 scientific ventures resulting in $19+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. FL70 is integrating the latest developments in molecular biology and plant biology to create a new platform technology that enables adaptive, targeted and sustainable solutions in agriculture.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Summary:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a Computational Biologist to join our passionate team of scientists. You will tackle computational challenges to uncover new insights about RNA biology and their potential applications for agriculture. Working alongside experimentalists, you will analyze next generation sequencing data to build our proprietary platform technology. Your role will also involve aspects of data management/infrastructure, computational biology and machine learning. The successful candidate is scientifically motivated self-starters, keen on modeling biological processes using rich datasets, able to thrive in a fast-paced entrepreneurial environment, and an integral part of a highly collaborative and interdisciplinary team. &amp;nbsp;Excellent communication, record-keeping, and teamwork will be critical.&lt;/p&gt;
&lt;p&gt;Flagship is an experiment in institutional, entrepreneurial, innovation practiced in the context of a small company with an insurgent mindset. &amp;nbsp;&amp;nbsp;We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment.&amp;nbsp; The level of the role will commensurate with the education and years of experience of the identified candidate.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Key Responsibilities: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Analyze RNA structure folding with public and proprietary datasets by developing new computational methods or leveraging existing methods&lt;/li&gt;
&lt;li&gt;Create and maintain pipelines for processing high-throughput next-generation sequencing data for RNA structure, genomics, and transcriptomics studies&lt;/li&gt;
&lt;li&gt;Maintain scientific and technical expertise through familiarity with scientific literature, attending conferences, and developing relationships with thought leaders&lt;/li&gt;
&lt;li&gt;Work closely with an entrepreneurial, highly-collaborative, interdisciplinary team and actively contribute to creating, shaping and executing the scientific and strategic vision of the company&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Minimum Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in RNA biology, Bioinformatics, Computer Science, Mathematics, Statistics or a related field&lt;/li&gt;
&lt;li&gt;Strong expertise in RNA structure determination, analysis and refinement.&lt;/li&gt;
&lt;li&gt;Extensive experience with modeling of RNA folding and tools to optimize RNA structure&lt;/li&gt;
&lt;li&gt;Experience with analysis of large datasets and next-generation sequencing data&lt;/li&gt;
&lt;li&gt;Strong programming skills in a scripting language such as Python or R&lt;/li&gt;
&lt;li&gt;A strong self-starter, independent thinker, with strong attention to detail.&lt;/li&gt;
&lt;li&gt;Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals&lt;/li&gt;
&lt;li&gt;Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.&lt;/li&gt;
&lt;li&gt;Confident execution focused, team-oriented with an ability to thrive in an entrepreneurial environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Deep understanding of statistics or machine learning, especially as it relates modeling biological processes using next-generation sequencing data&lt;/li&gt;
&lt;li&gt;Proficiency in creating reproducible workflows with an emphasis on Unix, Git, Jupyter or RMarkdown, and cloud computing environments such as Amazon Web Services&lt;/li&gt;
&lt;li&gt;Experience in creating dashboards or other utilities to allow biologists to investigate data independently&lt;/li&gt;
&lt;li&gt;Experience with RNA: protein complexes is preferred&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;More About Flagship Pioneering&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are creative optimists and we would love for you to consider joining our team!&amp;nbsp; See &lt;a href=&quot;https://www.flagshippioneering.com/join/roles&quot;&gt;all our open opportunities&lt;/a&gt; across Flagship Pioneering’s Ecosystem!&lt;/p&gt;
&lt;p&gt;&lt;a href=&quot;https://www.flagshippioneering.com/&quot;&gt;Flagship Pioneering&lt;/a&gt; conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including:&amp;nbsp; Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO),&amp;nbsp; Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).&lt;/p&gt;
&lt;p&gt;We believe pioneering is best done by teams, and that it is a process that can be taught, learned, and replicated.&amp;nbsp; Learn more about our &lt;a href=&quot;https://www.flagshippioneering.com/process&quot;&gt;Company Creation Model&lt;/a&gt;.&lt;/p&gt;
&lt;p&gt;Can Breakthrough Innovations Be Made Systematically&lt;a href=&quot;https://www.flagshippioneering.com/stories/can-innovations-be-made-systematically-a-conversation-with-noubar-afeyan&quot;&gt;? A Conversation With Noubar Afeyan&lt;/a&gt;, Flagship Pioneering’s CEO.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Recruitment &amp;amp; Staffing Agencies:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&amp;nbsp; Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.&amp;nbsp; The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.&amp;nbsp;&amp;nbsp; Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;/div&gt;
&lt;/div&gt;

Scientist, Computational Biology 

&lt;div class=&quot;content-intro&quot;&gt;&lt;p&gt;&lt;strong&gt;About Inari...&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Inari is the SEEDesign™ company. We embrace the diversity and complexity of nature in every aspect of our business to drive innovation – to push the boundaries of what is possible. Through our unrivaled technology platform, Inari uses predictive design and advanced multiplex gene editing to develop step-change products. We are taking a nature positive approach to unlock the full potential of seed that will transform the food system. The results will lead to more productive acres delivering value creation for farmers and a more sustainable future for our planet.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Our success is dependent on great minds, collaborating to generate bright ideas and deliver exceptional outcomes.&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We have over 200 employees, with research sites in Cambridge, MA (USA) and Ghent (Belgium), as well as a product development site in West Lafayette, IN (USA). We’ve deliberately built a team that brings diversity of thought to all aspects of our business, to generate new ideas, approaches, and ways of operating. And we&#x27;ve intentionally combined experience with potential, bringing agriculture industry experts with the desire to innovate together with bright minds from academia, human therapeutics, software, and consulting. If you want to be part of a diverse and inclusive team developing unique solutions to feed the world while protecting our planet’s natural resources, we’d love to hear from you!&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&lt;strong&gt;About the role...&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We are looking for a highly motivated and skilled Scientist to join Inari Agriculture, at our research site in Cambridge.&amp;nbsp; As a Molecular Biology Scientist you will join teams that are currently designing, developing, and applying innovative tools for genome engineering. You will specifically work on developing knowledge and applications of Inari&#x27;s proprietary genome engineering tools to the pharmaceutical industry.&amp;nbsp; As a member of our highly collaborative and multidisciplinary science organization, you will have the opportunity to contribute and develop your own ideas to address the most important challenges in modern agriculture and beyond.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;strong&gt;As a Molecular Biology Scientist, you will...&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Help lead Inari’s efforts to apply genetic engineering tools developed internally more broadly with a focus on application in the pharmaceutical industry&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Collaborate with scientists and research associates to design, execute, and coordinate lab experiments (e.g in vitro and in eukaryotic cell models); as well as interpret data, draw conclusions, and communicate results to different audiences.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Participate in discussions with the science and business development teams to provide technical expertise and help identify business opportunities for the company&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Serve as the main point of contact between project leads and external collaborators/providers to test our technologies in mammalian cells&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Document and present findings through clearly written reports and effective oral presentations&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;strong&gt;You bring...&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD or Masters degree (with equivalent experience of a PhD), and 2-4 years pharmaceutical or equivalent research experience in molecular biology, protein biochemistry, genetics, synthetic biology, or a related field&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Proficiency in common laboratory techniques for molecular cloning, protein characterization and nucleic acid analysis&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A track record of robust experimental design and results interpretation&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong understanding of molecular tools used in eukaryotic cell or mammalian genetic engineering techniques such as CRISPR-Cas, TALENs, &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Cre-lox&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;, homologous recombination, etc.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of the design, execution, and analysis of genome engineering experiments in mammalian cells&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge or experience applying genetic engineering technologies in the development of therapeutic applications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong interest in combining existing knowledge in a novel business development context&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Adaptability and enthusiasm for new challenges, innate curiosity, and a passion for learning&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Creative and strategic thinking, good problem solving skills, willingness to be bold and take risks, and the ability to recognize and learn from failures.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Integrity, transparency, and good communication skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent time management and organizational skills to ensure efficiency in planning and execution&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A collaborative mindset that is open to giving and receiving ideas, perspectives, and feedback.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ability to work both independently and deliver on responsibilities within a highly collaborative environment.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A strong sense of purpose and drive to develop unique, high impact solutions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ability to effectively communicate with a diverse range of individuals and audiences.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About Inari...&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Inari is the SEEDesign™ company. We embrace the diversity and complexity of nature in every aspect of our business to drive innovation – to push the boundaries of what is possible. Through our unrivaled technology platform, Inari uses predictive design and advanced multiplex gene editing to develop step-change products. We are taking a nature positive approach to unlock the full potential of seeds that will transform the food system. The results will lead to more productive acres delivering value creation for farmers and a more sustainable future for our planet.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Our success is dependent on great minds, collaborating to generate bright ideas and deliver exceptional outcomes.&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We have over 200 employees, with research sites in Cambridge, MA (USA) and Ghent (Belgium), as well as a product development site in West Lafayette, IN (USA). We’ve deliberately built a team that brings diversity of thought to all aspects of our business, to generate new ideas, approaches, and ways of operating. And we&#x27;ve intentionally combined experience with potential, bringing agriculture industry experts with the desire to innovate together with bright minds from academia, human therapeutics, software, and consulting. If you want to be part of a diverse and inclusive team developing unique solutions to feed the world while protecting our planet’s natural resources, we’d love to hear from you!&lt;/span&gt;&lt;/p&gt;

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