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Principal Machine Learning Engineer, Applied AI

Cambridge, MA USA; San Francisco, CA USA

Live, first seen by us 29 days ago
Pay
USD 252,000–336,000/year · BaseAnnual period assumed — pay source
Expected Base Salary Range $252,000—$336,000 USD About LILA
Read the full posting
Work setting
Not stated
Employment
Not stated

What you’ll work on

Full posting
  • Lead post-training of models with SFT and RL methods (DPO, PPO/GRPO)

  • Build and run evaluation loops measuring model quality, reliability, and customer fit

  • Turn customer learnings and evaluation results into model improvement cycles

  • Debug complex model failures using traces, evaluations, and customer context

  • Integrate model behavior into end-to-end product workflows with Software

From the employer’s posting
Lead post-training efforts using approaches such as SFT and RL (DPO, PPO/GRPO)
Build and run evaluation loops that measure model quality, reliability, and customer fit
Turn customer learnings, data signals, and evaluation results into concrete model improvement cycles
Debug complex model failures using traces, evaluations, customer context, and scientific feedback
Work with Software to integrate model behavior into end-to-end product workflows

About Lila Sciences

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges.

In the employer’s words · Read in context

Apply at Lila Sciences

Posting record

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Status in our records
Live
First seen by us
Oct 7, 202629 days ago
Recorded sightings
56
Last seen by us
Nov 5, 2026

These dates show when we found the posting. Check the employer’s website to confirm it is still accepting applications.

How this job compares

Pay

Higher than most similar jobs

$252K–$336K against $166K–$240K, the middle half of what similar US postings state.

From 1,279 postings in the last year. Stated ranges, not salaries paid.

Time since we first saw it

Day 29

Similar jobs usually come down between day 6 and day 70.

At Lila Sciences, jobs usually come down by about day 63.

From 4,481 similar postings that came down, and 12 of Lila Sciences’s. Coming down is not always a hire.

Lila Sciences is hiring

16 open jobs

Open jobs by the week we first saw them, last 12 weeks.

  • ML Engineer hiring is steady
  • Its jobs tend to stay up a long time
Hiring record

See how this role fits your experience

Add your resume and we’ll mark which of these tools you already use, and point out anything in the posting that could rule you out.

  • Python
  • PyTorch
Where the posting names them
- Minimum 2-3 years of hands-on post-training experience (SFT, RL methods such as DPO/PPO/GRPO) and evaluation system design, gained from having solved these problems many times before. - Strong software engineering skills in Python and modern ML frameworks like PyTorch. - A demonstrated ability to debug ambiguous, high-stakes model behavior quickly, using data, traces, logs, and qualitative feedback - the kind of judgment that only comes from having seen many failure modes before.

Your next step

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Demand for ML Engineer roles

New ML Engineer postings at the employers we follow are up 12% over the last 5 weeks compared with the 5 before.

Weekly new ML Engineer postings at the same employers, from the week of August 17 to the week of October 26. The fewest in a week was 625, the most 1,094, and the latest week had 876.
August 17Last week

Each bar is one week of new postings. The darkest bars are the last 5 weeks.

Counted from the hiring pages we’ve followed for at least five weeks, so employers we add don’t look like growth. Updated weekly.

About the role

We file this job under ML Engineer, by the work the posting describes.

ML engineers put machine learning models into products. They write the code that trains, ships, serves and monitors models so a recommendation or prediction works for real users.

Postings ask for strong Python and software engineering, a framework such as PyTorch, cloud services, and more and more often experience with large language models.

A data scientist often works out which model to build; an ML engineer makes it run reliably in production.

US government figures for computer and information research scientists

Median yearly pay, May 2025
$140,300
Expected change, 2025 to 2035
21.8% more jobsagainst 3.5% for all jobs

The government has no code for ML engineers, so these figures are for the closest group, computer and information research scientists.

Source: US Bureau of Labor Statistics, Occupational Employment and Wage Statistics (May 2025) and Employment Projections (2025 to 2035). Occupation code 15-1221.

Job description

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Your Impact at LILA

We are growing our Applied AI org and seeking a Principal Machine Learning Engineer, Applied AI  with deep expertise in model post-training, evaluation, and production-oriented ML systems. You’ll shape how Lila’s AI models are adapted to customer-specific scientific needs, with a focus on turning frontier model capabilities into reliable workflows that can be evaluated, iterated and used in real customer contexts.

Applied AI sits at the intersection of AI Research, model engineering, and product deployment. The team partners closely with AI Researchers and Software teams to adapt Lila models to customer workflows, improve model quality through post training and driving how harness engineering shapes model behavior inside the product.

This is a high-impact senior IC role for someone who brings deep, hands-on expertise in model post-training, evaluation, and production ML systems, built over many years of solving this exact class of problem.

What You'll Be Building

  • Apply deep, hands-on expertise to close the last-mile gap between Lila's model capabilities and customer-specific scientific workflows.
  • Lead post-training efforts using approaches such as SFT and RL (DPO, PPO/GRPO) to align model behavior with customer-specific requirements and feedback.
  • Build and run evaluation loops that measure model quality, reliability, and customer fit, using patterns you've refined across many prior projects.
  • Turn customer learnings, data signals, and evaluation results into concrete model improvement cycles.
  • Partner with AI researchers to translate model advances into reliable, usable capabilities.
  • Work with Software to integrate model behavior into end-to-end product workflows.
  • Debug complex model failures using traces, evaluations, customer context, and scientific feedback.
  • Mentor engineers and share reusable patterns for model adaptation, evaluation, and deployment, drawing on lessons learned across a long track record of shipping ML systems.

What You'll Need to Succeed

  • Minimum 2-3 years of hands-on post-training experience (SFT, RL methods such as DPO/PPO/GRPO) and evaluation system design, gained from having solved these problems many times before.
  • Strong software engineering skills in Python and modern ML frameworks like PyTorch.
  • A demonstrated ability to debug ambiguous, high-stakes model behavior quickly, using data, traces, logs, and qualitative feedback - the kind of judgment that only comes from having seen many failure modes before.
  • Experience leading technical work across research and engineering teams.
  • Deep familiarity with large language models, multi-modal models, or agentic AI systems.
  • Clear communication skills for translating customer needs into technical approaches, and for explaining complex model behavior to both technical and non-technical audiences.

Bonus Points For

  • Experience adapting models for customer-facing or production workflows, ideally in scientific, technical, or data-intensive domains.
  • Experience with RL post-training, such as RLHF, GRPO, or tool-augmented RL.
  • Experience building evaluation harnesses, model monitoring, or quality dashboards.
  • Experience training MoE architectures.
  • A track record of mentoring engineers and being sought out as a go-to technical expert, rather than a people manager or strategy owner.

Compensation

We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.

U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.

International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market.

Expected Base Salary Range
$252,000—$336,000 USD

About LILA

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.

LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai.

Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.

We’re All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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Pay
Expected Base Salary Range $252,000—$336,000 USD About LILA
Location & working pattern

Cambridge, MA USA; San Francisco, CA USA

Working pattern and location restrictions need checking in the full posting.

Work authorization
We’re All In Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

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