Pay
In line with similar jobs
$110K–$160K against $118K–$193K, the middle half of what similar US postings state.
From 3,721 postings in the last year. Stated ranges, not salaries paid.
Senior Machine Learning Infrastructure Engineer
- Pay
$110,000–160,000/year · BaseAnnual period assumed — pay source
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have a company culture that is relaxed, but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. Estimated base salary range: $110,000 - $160,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team. Sound exciting? Apply today and join us!
Read the full posting- Work setting
- Not stated
- Employment
- Not stated
What you’ll work on
Full postingYou'll own the infrastructure behind these products, across our own clusters and customer clouds on GCP and AWS.
Design isolation for multi-tenant agent sandboxes: network policy, workload identity, runtime sandboxing, and egress control
Build and operate locked-down partner environments with private networking, default-deny egress, just-in-time access, and audit logging
From the employer’s posting
As a member of the Machine Learning team, you’ll play a key role in building and maintaining the systems that put ML models and AI agents to work in drug discovery. LiveDesign ML trains and serves models on live project data, both in our own clusters and in customers' LiveDesign environments. Bunsen is an agentic platform where every session runs an AI agent in its own isolated Kubernetes pod. We also run locked-down environments for federated-learning collaborations with pharma partners. You'll own the infrastructure behind these products, across our own clusters and customer clouds on GCP and AWS. Today, ML engineers handle it alongside feature work. You'll make it your focus: repeatable customer deployments, strong isolation for AI-generated code, and reliable, cost-efficient GPU systems. Who will love this job:
Turn customer installs and upgrades into versioned, GitOps-driven releases (Helm, OpenTofu, Argo CD) with automated verification Design isolation for multi-tenant agent sandboxes: network policy, workload identity, runtime sandboxing, and egress control Secure CI/CD and the software supply chain with keyless auth, ephemeral runners, and pinned, signed images
Secure CI/CD and the software supply chain with keyless auth, ephemeral runners, and pinned, signed images Build and operate locked-down partner environments with private networking, default-deny egress, just-in-time access, and audit logging Keep GPU-heavy training and inference reliable and cost-efficient, backed by observability, SLOs, and on-call
Posting record
Report an errorActively hiringFirst seen by us today, still listed, and not a repost of an earlier posting.
- Status in our records
- Live
- First seen by us
- Nov 4, 2026today
- Recorded sightings
- 1
These dates show when we found the posting. Check the employer’s website to confirm it is still accepting applications.
How this job compares
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From 10,019 similar postings that came down. Coming down is not always a hire.
Schrödinger is hiring
1 open job
Open jobs by the week we first saw them, last 12 weeks.
Hiring recordSee how this role fits your experience
Add your resume and we’ll mark which of these tools you already use, and point out anything in the posting that could rule you out.
- Python
- AWS
- GCP
- Kubernetes
- Terraform
Where the posting names them
- A Terraform or OpenTofu and Helm writer who has shipped with GitOps - A solid Python and shell scripter - A security-minded engineer who defaults to least privilege, managed secrets, and segmented networks
As a member of the Machine Learning team, you’ll play a key role in building and maintaining the systems that put ML models and AI agents to work in drug discovery. LiveDesign ML trains and serves models on live project data, both in our own clusters and in customers' LiveDesign environments. Bunsen is an agentic platform where every session runs an AI agent in its own isolated Kubernetes pod. We also run locked-down environments for federated-learning collaborations with pharma partners. You'll own the infrastructure behind these products, across our own clusters and customer clouds on GCP and AWS. Today, ML engineers handle it alongside feature work. You'll make it your focus: repeatable customer deployments, strong isolation for AI-generated code, and reliable, cost-efficient GPU systems. Who will love this job:
- In-depth understanding of Kubernetes operation (not just deployment) - Robust background with GCP (and some familiarity with AWS) We’d prefer to hire someone who has experience with:
We’re seeking a Senior Machine Learning Infrastructure Engineer to join us in our mission to transform the discovery of therapeutics and materials. As a member of the Machine Learning team, you’ll play a key role in building and maintaining the systems that put ML models and AI agents to work in drug discovery. LiveDesign ML trains and serves models on live project data, both in our own clusters and in customers' LiveDesign environments. Bunsen is an agentic platform where every session runs an AI agent in its own isolated Kubernetes pod. We also run locked-down environments for federated-learning collaborations with pharma partners. You'll own the infrastructure behind these products, across our own clusters and customer clouds on GCP and AWS. Today, ML engineers handle it alongside feature work. You'll make it your focus: repeatable customer deployments, strong isolation for AI-generated code, and reliable, cost-efficient GPU systems.
- At least six years of infrastructure, platform, or SRE experience - In-depth understanding of Kubernetes operation (not just deployment) - Robust background with GCP (and some familiarity with AWS)
We’d prefer to hire someone who has experience with: - Running GPU workloads and model serving (vLLM, Knative) on Kubernetes - Sandboxing untrusted code (gVisor, Kata Containers, Cilium)
Who will love this job: - A Terraform or OpenTofu and Helm writer who has shipped with GitOps - A solid Python and shell scripter
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About the role
We file this job under Data Scientist, by the work the posting describes.
Data scientists use statistics and models to answer harder questions, such as whether a change worked, what demand will look like next quarter, or which customers are likely to leave.
Postings usually ask for Python or R, SQL, statistics, experiment design and common machine learning methods.
Unlike an ML engineer, a data scientist's main output is often an analysis or a first model, not software running inside a product.
US government figures for data scientists
- Median yearly pay, May 2025
- $120,230
- Expected change, 2025 to 2035
- 34.6% more jobsagainst 3.5% for all jobs
Source: US Bureau of Labor Statistics, Occupational Employment and Wage Statistics (May 2025) and Employment Projections (2025 to 2035). Occupation code 15-2051.
Job description
We’re seeking a Senior Machine Learning Infrastructure Engineer to join us in our mission to transform the discovery of therapeutics and materials.
As a member of the Machine Learning team, you’ll play a key role in building and maintaining the systems that put ML models and AI agents to work in drug discovery. LiveDesign ML trains and serves models on live project data, both in our own clusters and in customers' LiveDesign environments. Bunsen is an agentic platform where every session runs an AI agent in its own isolated Kubernetes pod. We also run locked-down environments for federated-learning collaborations with pharma partners.You'll own the infrastructure behind these products, across our own clusters and customer clouds on GCP and AWS. Today, ML engineers handle it alongside feature work. You'll make it your focus: repeatable customer deployments, strong isolation for AI-generated code, and reliable, cost-efficient GPU systems.
Who will love this job:
- A Terraform or OpenTofu and Helm writer who has shipped with GitOps
- A solid Python and shell scripter
- A security-minded engineer who defaults to least privilege, managed secrets, and segmented networks
- A clear communicator who enjoys working closely with ML engineers and scientists
What you’ll do:
- Turn customer installs and upgrades into versioned, GitOps-driven releases (Helm, OpenTofu, Argo CD) with automated verification
- Design isolation for multi-tenant agent sandboxes: network policy, workload identity, runtime sandboxing, and egress control
- Secure CI/CD and the software supply chain with keyless auth, ephemeral runners, and pinned, signed images
- Build and operate locked-down partner environments with private networking, default-deny egress, just-in-time access, and audit logging
- Keep GPU-heavy training and inference reliable and cost-efficient, backed by observability, SLOs, and on-call
What you should have:
- At least six years of infrastructure, platform, or SRE experience
- In-depth understanding of Kubernetes operation (not just deployment)
- Robust background with GCP (and some familiarity with AWS)
We’d prefer to hire someone who has experience with:
- Running GPU workloads and model serving (vLLM, Knative) on Kubernetes
- Sandboxing untrusted code (gVisor, Kata Containers, Cilium)
- Shipping software into customer-owned or restricted-egress clouds
- Argo Workflows or batch/HPC scheduling
- Regulated environments (SOC 2, ISO 27001, GxP)
- Operating LLM or agent platforms
Pay and perks:
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have a company culture that is relaxed, but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.
Estimated base salary range: $110,000 - $160,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.
Sound exciting? Apply today and join us!
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.
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- Pay
Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have a company culture that is relaxed, but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. Estimated base salary range: $110,000 - $160,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team. Sound exciting? Apply today and join us!
- Location & working pattern
New York
Working pattern and location restrictions need checking in the full posting.
- Work authorization
Sound exciting? Apply today and join us! As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.