&lt;p&gt;&lt;strong&gt;Why join Freenome?&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To fight the war on cancer, Freenome has raised more than $1.1B from leading investors including a16z, GV (formerly Google Ventures), T. Rowe Price, BainCapital, Perceptive Advisors, RA Capital Management, Roche, Kaiser Permanente Ventures, and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Are you ready for the fight? A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrive in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career. Freenomers are determined, patient-centric, and outcomes-driven. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. We are dedicated to advancing healthcare, one breakthrough at a time.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;br&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About this opportunity:&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Join our growing team and play a key role in supporting and organizing the culture of efficiency within the clinical laboratory. &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We are looking for a motivated, Product Analyst to help the team deliver our ground-breaking Laboratory Information System platform and support Clinical Laboratory operations. You will support end users as they use the system and build out an efficient foundational support system and documentation, including&amp;nbsp; Automation, IT and LIMS.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll do:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Work as the tier one support for the laboratory informatics system as the Clinical Laboratory processes samples.&amp;nbsp; Resolve bugs and errors as they arise during sample processing and improve the support tracking process.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Support swing shift Laboratory operations, working hours will be from 230pm-11pm Monday through Friday with a rotating on-call schedule for weekend support.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Update system and user workflows for laboratory procedures that interact with informatics systems to further improve lab practices.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Support IT and Automation teams as tier one support.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Must haves:&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Undergraduate degree in the life sciences,&amp;nbsp; information technology, computer science, or closely related field&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience working with LIMS systems with a high-level understanding of clinical laboratory workflows&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience working in a regulated environment: CLIA, ISO, FDA with an understanding of related requirements&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to haves:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience in Agile and or Scrum development, prior use of JIRA or related technologies.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience working in a support role for a production environment.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Additional information:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Contractors may be hired through a third-party provider and will be considered contingent workers. &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We invite you to check out our career page @ &lt;/span&gt;&lt;a href=&quot;https://careers.freenome.com/&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;https://careers.freenome.com/&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; for additional company information.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;law.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300; color: #ecf0f1;&quot;&gt;#LI-Onsite&lt;/span&gt;&lt;/p&gt;

Support Analyst II (Contractor - 2nd shift)

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali is seeking a Scientist in support of small molecule and biomarker bioanalysis efforts within the Bioanalysis group. You will work closely with DMPK, Omics and Biomarker scientists, develop LC-MS/MS methods, and quantitate drug candidates, metabolites, and biomarkers from in vitro and in vivo samples.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Develop and qualify fit-for-purpose LC-MS/MS assays; perform assay maintenance testing of&lt;br&gt;LC-MS/MS methods&lt;/li&gt;
&lt;li&gt;Perform bioanalysis of small molecules and biomarkers in various biological matrices&lt;br&gt;including plasma, urine, CSF, and tissues&lt;/li&gt;
&lt;li&gt;Work with novel biotherapeutic analytes and contribute to development of mass spectrometry&lt;br&gt;methods and analyses for oligonucleotides and proteins&lt;/li&gt;
&lt;li&gt;Work with DMPK scientists to develop assays to support in vitro ADME and PK studies&lt;/li&gt;
&lt;li&gt;Interpret data, write scientific reports, review, and QC incoming data from CROs, and&lt;br&gt;communicate bioanalysis results to other scientists and project teams&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD in Analytical Chemistry, Pharmaceutical Chemistry, Drug Metabolism,Pharmacokinetics, or related scientific discipline&lt;/li&gt;
&lt;li&gt;OR Master&#x27;s degree and 3+ years of biotech/pharmaceutical or CRO experience in LC-MS/MS bioanalysis&lt;/li&gt;
&lt;li&gt;OR Bachelor&#x27;s degree and 6+ years of biotech/pharmaceutical or CRO experience in LC-MS/MS bioanalysis&lt;/li&gt;
&lt;li&gt;Hands-on experience with various sample preparation techniques (protein precipitation,&lt;br&gt;liquid-liquid extraction, and solid-phase extraction), chromatographic separation, and&lt;br&gt;operation of triple-quadrupole mass spectrometers&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work effectively and collaboratively with other scientists on cross-&lt;br&gt;functional Project Teams&lt;/li&gt;
&lt;li&gt;Excellent oral presentation and written communication skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Working knowledge of quantitative bioanalytical principles, with GLP/GCP regulated assay&lt;br&gt;experience&amp;nbsp;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/p&gt;
&lt;p&gt;Salary Range: $121,000 - $153,000.&amp;nbsp; Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers&lt;/p&gt;
&lt;p&gt;This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;

Scientist, Bioanalysis

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is seeking a Senior Manager, Biomarker Operations in support of the company’s Development Operations group. You will manage the biospecimen lifecycle for Denali’s clinical programs through collaboration with Clinical Operations, Data Management, Translational Science, Biomarker and Pharmacology scientists, and external vendors that support Denali’s clinical studies. You will also supervise and train BMO clinical study leads.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Development of biospecimen lifecycle strategies through close collaboration with project teams and biomarker scientists&lt;/li&gt;
&lt;li&gt;Ensure program level consistency and cross-program standardization of biospecimen collection, processing, storage, and analysis&lt;/li&gt;
&lt;li&gt;Supervise, support and train Biomarker Operations clinical study leads&lt;/li&gt;
&lt;li&gt;Contribute to development of study protocols, ICFs and other relevant study documents&lt;/li&gt;
&lt;li&gt;Collaborate with Clinical Operations, Procurement and Quality in the selection and management of central laboratories and specialty bioanalysis labs to ensure they meet study requirements and adhere to relevant compliance standards&lt;/li&gt;
&lt;li&gt;Manage the creation of complex sample management plans and laboratory documents that ensure the proper collection and storage of samples at clinical sites&lt;/li&gt;
&lt;li&gt;Create systems and tools to manage sample analysis plans and enable study leads to deliver samples to appropriate analysis vendors on time&lt;/li&gt;
&lt;li&gt;Facilitate biomarker vendor interactions with Data Management to ensure consistency in the transmission of sample metadata for accurate identification of analyzed samples&lt;/li&gt;
&lt;li&gt;Design LIMS study collection plans to allow real-time import of incoming samples into Biosample Management’s LIMS Database. This requires coordination with scientists, CROs and vendors and ability to interpret clinical study protocols.&lt;/li&gt;
&lt;li&gt;Lead process improvement projects&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor’s degree in Biology, Immunology, Neuroscience, Medical Technology, or related field plus 7+ years of experience in Clinical Operations, Translational Sciences, Biomarker Operations,&lt;/li&gt;
&lt;li&gt;OR combination of advanced degree in relevant field with 5+ years of experience&lt;/li&gt;
&lt;li&gt;Ability to lead effectively in a cross-functional team matrix environment&lt;/li&gt;
&lt;li&gt;Working knowledge of biosample management for clinical trials. Familiarity with relevant FDA &amp;amp; ICH/GCP regulations is&lt;/li&gt;
&lt;li&gt;Ability to review and interpret clinical research protocols&lt;/li&gt;
&lt;li&gt;Technical know how to create tools to solve operational challenges and improve workflows&lt;/li&gt;
&lt;li&gt;Entrepreneurial spirit with “can do” attitude and commitment to work as part of a team&lt;/li&gt;
&lt;li&gt;Seeks change &amp;amp; values innovation&lt;/li&gt;
&lt;li&gt;Advanced planning and organization skills and excellent analytical skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/p&gt;
&lt;p&gt;Salary Range: $158,000 - $181,333. &amp;nbsp;Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at &lt;a href=&quot;https://www.denalitherapeutics.com/careers&quot;&gt;https://www.denalitherapeutics.com/careers&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior Manager, Biomarker Operations

&lt;p&gt;&lt;strong&gt;Why join Freenome?&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To fight the war on cancer, Freenome has raised more than $1.1B from leading investors including a16z, GV (formerly Google Ventures), T. Rowe Price, BainCapital, Perceptive Advisors, RA Capital Management, Roche, Kaiser Permanente Ventures, and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Are you ready for the fight? A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrive in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career. Freenomers are determined, patient-centric, and outcomes-driven. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. We are dedicated to advancing healthcare, one breakthrough at a time.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;strong&gt;About this opportunity:&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;As a Staff Computational Biologist on the Computational Biology, Assay Research and Development team at Freenome, you will help build novel NGS and immunological assays for early, noninvasive tests for cancer detection. You will bring a strong foundation in molecular biology and genomics to perform computational analyses enabling us to understand and identify cancer’s unique molecular signatures. You will work in close collaboration with wet lab scientists and other computational scientists to both iterate upon and build new assays with the goal of developing clinical products that save lives. This role will report to the Manager and Staff Computational Biologist.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll do:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Drive computational analysis in collaboration with wet-lab scientists to rapidly characterize and iterate on experimental methods by providing real-time assessments of assay performance, quality control, and clinical/diagnostic utility.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Build bioinformatics pipelines and bespoke computational tools to extract actionable information from high-throughput sequencing datasets for cancer classification.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Develop classification models using novel molecular/immunological signatures and evaluate feasibility translating these biomarkers to the product development phase.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Remain at the forefront of molecular techniques in onco immunology and develop scalable, automated laboratory and bioinformatic workflows to generate and analyze the data.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;strong&gt;Must haves:&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD or equivalent experience in a relevant field such as molecular biology, computational biology, bioinformatics, or equivalent.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;3+ years post-PhD experience, industry experience in Immunological assays, protein (amino acid) sequence analysis, modeling, and embeddings.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Strong computational and programming skills, including experience with Python statistical packages (Numpy, Matplotlib, Pandas).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Solid quantitative reasoning and statistical analysis skills, with a demonstrated ability to apply them effectively to relevant scientific problems.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Expertise in computational analysis of NGS datasets to derive technical and biological insights. Experience in protein display technologies or&lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; de novo &lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;antibody engineering/design is particularly relevant.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience building and maintaining bioinformatics pipelines, with proficiency in common bioinformatics tools, such as FastQC, Bowtie, IGV.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Familiarity with software version control (Git) and common workflow languages (SnakeMake, Nextflow, Flyte).&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience implementing modern deep learning methods in biological sequence analysis for motif discovery and sample classification (convolutional and recurrent neural networks, HMMs, etc).&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Fundamental understanding of the central dogma, including background in molecular biology, cancer biology, and familiarity with regulation of molecular processes.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Familiarity working in a Linux server-based environment.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Excellent oral and written communication skills to communicate to both scientific and broader audiences.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to work on a cross-functional team in our highly collaborative environment, working with both computational and experimental scientists.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Benefits and additional information:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;The US target range of our base salary/hourly rate for new hires is $182,750 - $280,000. &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;You will also be eligible to receive pre-IPO equity, cash bonuses, and a full range of medical, financial, and other benefits dependent on the position offered.&amp;nbsp; Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page&amp;nbsp;&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;@ &lt;/span&gt;&lt;a href=&quot;https://careers.freenome.com/&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;https://careers.freenome.com/&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; for additional company information.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;law.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior Computational Biologist

&lt;h4&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/h4&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The Associate Director/Director of Clinical Data Management will be responsible for supporting assigned clinical development programs in the data management area;&amp;nbsp; provide an oversight for vendor&#x27;s performance including database setup,&amp;nbsp; CRF design, data collections and database lock; develop SOPs related to data management; In addition, he/she may collaborate with internal and external partners to optimize clinical data collection and ensure data quality of clinical studies and to advance exciting drug candidates in clinical development programs.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico provides a scientifically stimulating and collaborative working environment and the successful candidate will interact with scientists from a range of disciplines including biostatistics, basic research, computational biology, pharmacology, PKPD and biomarker experts.&amp;nbsp;We are seeking an experienced data manager to direct project teams and external vendors towards efficient strategies for clinical data collection and integration across multiple platforms with the ultimate goal of deriving meaningful inferences about the human condition.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;BS with at least 10 years or MS with at least 8 years relevant work experience&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Understanding of clinical development process, CDISC standards and health authority guidelines and regulations; Knowledge of data management tools and platforms&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Demonstrated ability to establish effective business process and relationships with external stakeholders, including implementation process change at a vendor or partner&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent written and oral communication skills and interpersonal skills; capability to work within a team environment and manage competing priorities in a changing environment&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least three days per week&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The estimated base salary range for this role is $200,000 - $245,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2 id=&quot;ojxVC&quot; class=&quot;wLzlc&quot;&gt;&lt;/h2&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Associate Director/Director, Clinical Data Management

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The Associate Director of Biostatistics will be responsible for providing statistical data analysis expertise to support assigned clinical programs/complex studies. He/she will work with cross functional teams and oversee study design, data collection and analysis, to ensure rigorous quantitative analyses in decision making for early clinical programs.&amp;nbsp; In addition, he/she may collaborate with internal and external partners to optimize clinical study design and ensure rigorous execution of study protocols and study statistical strategies to advance exciting drug candidates in early-stage development programs.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico provides a scientifically stimulating and collaborative working environment and the successful candidate will interact with scientists from a range of disciplines including basic research, computational biology, pharmacology, PKPD and biomarker experts.&amp;nbsp;We are seeking a creative and innovative statistical scientist to direct project teams towards efficient strategies for data integration across multiple platforms with the ultimate goal of deriving meaningful inferences about the human condition.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ph.D. in Biostatistics/Statistics or equivalent with at least 6 years relevant work experiences or MS in Biostatistics/Statistics with at least 8 years relevant experience&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Broad and thorough understanding of statistical principles and clinical trial methodology; able to practice and implement them.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ability to develop innovative/creative statistical/technical solutions to complex problems.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge and experience in meeting regulatory guidelines, both FDA and international regulatory agencies.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Broad knowledge of medical/biological terminology and clinical trial designs in relevant therapeutic areas.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Leadership skills in priority evaluation, adapting to changes, conflicts resolution, and effective partnership.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least three days per week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The estimated base salary range for this role is $223,000 - $233,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;

Associate Director, Biostatistics

&lt;p&gt;Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. The Biomarker Operations group in Development Operations supports biomarker development through management of high quality clinical and pre-clinical sample.&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is seeking to recruit a Biorepository Specialist in support of the company’s Translational Science and Clinical Operations groups. This individual supports Biomarker Operations for all Biomarker Biorepository activities for Clinical and Preclinical studies, and Biomarker collaborations. Also, this position supports the management of on-site and off-site biological samples and tissues owned by the Translational Science group. Additional tasks include participating in process improvement projects and maintaining the biorepository Laboratory Information Management System (LIMS) database.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Responsibilities&lt;/u&gt;&lt;/strong&gt;&lt;strong&gt;:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Accurately follow SOPs and work instructions to track, receive, and store samples using the biorepository LIMS system&lt;/p&gt;
&lt;p&gt;Work with Biomarker Scientists to fulfill sample requests and facilitate sample returns.&lt;/p&gt;
&lt;p&gt;Prepare accurate sample manifests for outgoing shipments and Biomarker Scientists’ requests.&lt;/p&gt;
&lt;p&gt;Receive incoming sample shipments and ensure sample integrity during unpacking, accessioning and banking.&lt;/p&gt;
&lt;p&gt;Prepare outgoing shipments to comply with sample transportation regulations and ensure sample integrity during sample retrieval and packing.&lt;/p&gt;
&lt;p&gt;Schedule outgoing shipments including international shipments and work with Denali Receiving and Shipping department, shipping carriers and destination laboratories to ensure samples arrive viable and on time.&lt;/p&gt;
&lt;p&gt;Maintain an accurate, up-to-date inventory within LIMS.&lt;/p&gt;
&lt;p&gt;Assist biorepository staff with special technical projects and infrastructure processes as assigned.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&lt;u&gt;Requirements&lt;/u&gt;&lt;/strong&gt;&lt;strong&gt;:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;1-3 years work experience in a laboratory setting, ideally working with biological samples in a Biorepository&lt;/p&gt;
&lt;p&gt;Bachelor’s degree in Biology, Medical Technology, or related field (preferred), or equivalent combination of education and experience.&lt;/p&gt;
&lt;p&gt;Proficient with database entry (e.g., LIMS) and with Excel; additional technical experience preferred (excel coding, R programming, SQL, etc.)&lt;/p&gt;
&lt;p&gt;Commitment to teamwork and strong “can do” attitude&lt;/p&gt;
&lt;p&gt;Strong customer service focus&lt;/p&gt;
&lt;p&gt;Excellent organization skills, ability to meet tight deadlines and to quickly adapt to changing priorities.&lt;/p&gt;
&lt;p&gt;Proficient in performing tasks that require high level of attention to detail&lt;/p&gt;
&lt;p&gt;Ability to work effectively in a cross-functional team matrix environment&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Biorepository Specialist (12 month contract)

&lt;p&gt;Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing, and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised and/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact muscle function and contractility.&lt;/p&gt;
&lt;p&gt;This role will report to the Senior Director, Clinical Data Management and be accountable for the strategic leadership and functional management of an area of Clinical Data Management in adherence to company SOPs and ICH/GCP. This role ensures the development and readiness of personnel to deliver on existing programs while also being forward-looking and innovative.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Provide a high level of expertise in data management to support data collection activities&lt;/li&gt;
&lt;li&gt;Promote standardization, automation, process improvement and technical enhancement in CDM to improve efficiency&lt;/li&gt;
&lt;li&gt;Lead in the establishment of CDM processes, including identifying, authoring SOPs and Work Instructions to ensure regulatory compliance, GCP, and ICH&lt;/li&gt;
&lt;li&gt;Assist in budget forecast and management of CDM project budgets, timelines and resources&lt;/li&gt;
&lt;li&gt;Coordinate the development of key control documents (e.g., data management plans and related documents)&lt;/li&gt;
&lt;li&gt;Lead detailed professional development and provide strong support for direct reports and other members of the CDM department&lt;/li&gt;
&lt;li&gt;Strategic leadership and functional mentorship for internal data management staff&lt;/li&gt;
&lt;li&gt;Provide leadership and direction for outsourced activities including quality control and budget&lt;/li&gt;
&lt;li&gt;Lead all aspects of all assigned clinical trials to ensure data quality, integrity and timeliness&lt;/li&gt;
&lt;li&gt;Join the CDM leadership team to establish department goals and objectives&lt;/li&gt;
&lt;li&gt;Lead and coordinate evaluation, selection, qualification and implementation of vendor technology including data visualization tools (i.e. Spotfire, Elluminate)&lt;/li&gt;
&lt;li&gt;Complete budget assessment, contract negotiations, training and oversight for DM outsourced services from study start-up through study close-out and final reporting&lt;/li&gt;
&lt;li&gt;Oversee leading and tracking work orders associated with clinical DM activities to ensure that the operating costs for the DM department are achieved within budget.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;em&gt;Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BS Degree in related field with 10+ years of experience in Clinical Data Management at a CRO, biotechnology, or pharmaceutical company, plus 4+ years of management experience&lt;/li&gt;
&lt;li&gt;Must have experienced knowledge of good data management practices in global clinical trials&lt;/li&gt;
&lt;li&gt;Detailed knowledge of applicable regulatory rules and guidelines&lt;/li&gt;
&lt;li&gt;Sophisticated and/or international trials experience&lt;/li&gt;
&lt;li&gt;Showed talent in the data management processes&lt;/li&gt;
&lt;li&gt;Possesses excellent interpersonal communication skills (written and verbal)&lt;/li&gt;
&lt;li&gt;Strong attention to detail&lt;/li&gt;
&lt;li&gt;CDSIC expertise&lt;/li&gt;
&lt;li&gt;Proficient in the use of the clinical data management systems (e.g. Medidata Rave)&lt;/li&gt;
&lt;li&gt;Possesses a positive demeanor and works well with others&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Salary pay range: &lt;span class=&quot;collapsed-field-text&quot;&gt;$225,000 - $275,000. Actual salary at the time of hire may vary and may be above or below the range based on various factors, including, but not limited to, the candidate’s relevant qualifications, skills, and experience, as well as the service line and location where this position may be filled.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: center;&quot;&gt;Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.&lt;/p&gt;
&lt;p style=&quot;text-align: center;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: center;&quot;&gt;&lt;strong&gt;Please visit our website at: www.cytokinetics.com&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: center;&quot;&gt;&lt;strong&gt;Cytokinetics is an Equal Opportunity Employer&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

Director, Clinical Data Management

&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an intern to join the Calico Applied Machine Learning (CAML) team.&amp;nbsp;To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems.&amp;nbsp; In this position you will develop and apply sequence design and protein folding models to problems of practical interest.&amp;nbsp; You will identify and solve specific problems relating to the scalability and accuracy of these models. The successful candidate will work closely with members of the machine learning team on advancing the state-of-the-art in protein language modeling, structure prediction, and design.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Work within an interdisciplinary team to implement and extend machine learning algorithms for protein sequence and structure modeling and evaluate their performance on large protein datasets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Quickly iterate and improve on technical contributions in-house and from protein modeling literature&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Contribute easily maintainable, robust, and flexible code for model training and pipelines&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Interpret and communicate results to both team members and a wider audience of interdisciplinary scientists&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Currently pursuing a MS or PhD degree in computer science, computational biology, statistics, applied mathematics, or related field&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with Python and PyTorch, TensorFlow, JAX or related ML frameworks&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of modern machine learning techniques, including their strengths and shortcomings&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Track record of applying machine learning methods to solve problems at scale&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong analytical and quantitative problem solving skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Detail-oriented and organized&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong teamwork and communication skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Self-motivated with a “can-do” attitude&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least four days per week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with language models for biological sequence data, structure prediction models such as AlphaFold, ESMFold, OmegaFold, etc. and/or inverse folding models for de novo protein design&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience applying machine learning to problems in the physical sciences, especially biology or chemistry&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Familiarity with high performance computing clusters, cloud computing tools, or similar&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About our Program:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;. Students from all schools, and students who identify with a demographic that is underrepresented within the technology, data science, and healthcare industries are encouraged to apply. This includes but is not limited to Black, Latinx, Native American, students with disabilities, veterans, and non-binary people.&lt;/span&gt;&lt;/p&gt;
&lt;h4&gt;&lt;strong&gt;Program Features:&lt;/strong&gt;&lt;/h4&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;3-month summer timeline&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-person experience at our offices in South San Francisco&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Matching with at least one Calico mentor&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;End-of-summer company-wide project showcase and poster session&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Competitive compensation ($40 - $65/hour) and monthly living expenses stipend&lt;/li&gt;
&lt;/ul&gt;

Intern, Machine Learning & Protein Engineering (MS or PhD)

&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an intern to join the Kelley group.&amp;nbsp;To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems.&amp;nbsp; In this position you will explore cutting edge techniques for training machine learning models of regulatory sequences and applying them to predict the effect of genetic variants on gene regulation. The successful candidate will work closely with members of the Kelley group on our ongoing research program to understand the sequence basis of gene regulation with deep neural network models (e.g. Avsec 2021). The ML literature suggests several techniques to improve model accuracy or speed that we hope to explore during this internship. These improvements would greatly benefit Calico efforts to determine mechanisms for human genetic associations with aging phenotypes.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Avsec, Ž. et al. Effective gene expression prediction from sequence by integrating long-range interactions. Nat Methods 18, 1196–1203 (2021).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Build and improve upon current state-of-the-art deep neural network models for biological sequence analysis.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop effective techniques for large-scale genetic variant effect prediction and interpretation.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Currently pursuing a&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; PhD degree in computational biology, computer science, or a related field&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with deep neural networks&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of gene regulation and genomics assays like RNA-seq, ATAC-seq, and ChIP-seq.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Detail-oriented and organized&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong teamwork and communication skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Self-motivated with a “can-do” attitude&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least four days per week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About our Program:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;. Students from all schools, and students who identify with a demographic that is underrepresented within the technology, data science, and healthcare industries are encouraged to apply. This includes but is not limited to Black, Latinx, Native American, students with disabilities, veterans, and non-binary people.&lt;/span&gt;&lt;/p&gt;
&lt;h4&gt;&lt;strong&gt;Program Features:&lt;/strong&gt;&lt;/h4&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;3-month summer timeline&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-person experience at our offices in South San Francisco&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Matching with at least one Calico mentor&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;End-of-summer company-wide project showcase and poster session&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Competitive compensation ($40 - $65/hour) and monthly living expenses stipend&lt;/li&gt;
&lt;/ul&gt;

Intern, Regulatory Sequence Machine Learning (PhD)

&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an intern to join the Statistical Genetics team within the Data Science group.&amp;nbsp;To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems.&amp;nbsp; In this position you will conduct and interpret genetic association studies of complex traits related to aging, and integrate findings from these studies with other molecular and phenotypic datasets. The successful candidate will work closely with members of the data science, computer vision, and computational genomics groups to identify genes or pathways underpinning age-related decline in physiological function.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Conduct and interpret statistical genetic analyses such as GWAS, ExWAS, Mendelian randomization, statistical finemapping, colocalization, and/or multi-trait analyses to answer questions related to aging physiology&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and apply statistical machine learning methods to integrate multiple large, multimodal datasets (e.g. GWAS, clinical imaging, proteomics, genomics)&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Currently pursuing a PhD degree in statistics, computational biology, mathematical biology, statistical genetics, genomics, or related field&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience developing statistical and machine learning methods for biobank-scale biomedical datasets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience of large-scale statistical analysis in R and/or python&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of statistical genetics techniques&amp;nbsp; (e.g: GWAS, ExWAS, PheWAS, finemapping, colocalization, Mendelian randomization)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Detail-oriented and organized&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong teamwork and communication skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Self-motivated with a “can-do” attitude&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least four days per week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in computer vision or biomedical imaging&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with multi-omics datasets (genomics, proteomics, metabolomics)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of advanced statistical modeling techniques such as causal inference methods&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;About our Program:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico’s internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;. Students from all schools, and students who identify with a demographic that is underrepresented within the technology, data science, and healthcare industries are encouraged to apply. This includes but is not limited to Black, Latinx, Native American, students with disabilities, veterans, and non-binary people.&lt;/span&gt;&lt;/p&gt;
&lt;h4&gt;&lt;strong&gt;Program Features:&lt;/strong&gt;&lt;/h4&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;3-month summer timeline&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-person experience at our offices in South San Francisco&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Matching with at least one Calico mentor&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;End-of-summer company-wide project showcase and poster session&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;Competitive compensation ($40 - $65/hour) and monthly living expenses stipend&lt;/li&gt;
&lt;/ul&gt;

Intern, Data Science - Statistical Genetics (PhD)

&lt;div class=&quot;p-pdf_iframe__page&quot; data-page-number=&quot;1&quot;&gt;&amp;nbsp;&lt;/div&gt;
&lt;h2&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;About Twist Bioscience&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.&lt;/span&gt;&lt;/p&gt;&lt;div class=&quot;content-pay-transparency&quot;&gt;&lt;div class=&quot;pay-input&quot;&gt;&lt;div class=&quot;description&quot;&gt;The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final &lt;span class=&quot;il&quot;&gt;compensation&lt;/span&gt; amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. &lt;span class=&quot;il&quot;&gt;Compensation&lt;/span&gt; may be different in other locations.&lt;/div&gt;&lt;div class=&quot;title&quot;&gt;San Francisco Bay Area Pay Range&lt;/div&gt;&lt;div class=&quot;pay-range&quot;&gt;&lt;span&gt;$145,000&lt;/span&gt;&lt;span class=&quot;divider&quot;&gt;&amp;mdash;&lt;/span&gt;&lt;span&gt;$167,000 USD&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;

Sr, IT SOX Compliance Analyst

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an exceptional Senior/Principal Research Associate who is excited to be part of a research team exploring mechanisms of tissue homeostasis and aging. The selected candidate will employ cutting-edge cellular and microscopy approaches in mouse and human tissues to understand what goes wrong as tissues age and in age-associated diseases. In this role you will be able to work both independently and collaboratively and contribute to several projects in the &lt;/span&gt;&lt;a href=&quot;https://www.calicolabs.com/people/astrid-gillich-ph-d&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;Gillich lab&lt;/span&gt;&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;and multi-disciplinary research with Calico scientists. The ideal candidate will be a skilled, thoughtful, and organized experimentalist with a passion for research, attention to detail and exceptional planning, problem-solving and critical thinking skills. This position is ideal for a candidate seeking to perform early-stage discovery research in a dynamic R&amp;amp;D environment with an opportunity to expand their skill set. &lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;BS or MS degree with 2+ years of laboratory research experience. Salary and title commensurate with experience&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience or interest in cell/tissue analysis using immunohistochemistry, in situ hybridization, and advanced microscopy&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Strong attention to detail, excellent planning and problem-solving skills&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Candidate must be self-motivated, organized and adaptable, being able to learn quickly, respond to shifting priorities and handle projects simultaneously&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice To Have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with cell/tissue processing for microscopy, flow cytometry, transcriptome profiling and/or cell culture&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with cell/nuclei isolation from mouse and human tissues and single-cell library preparation for NGS&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Familiarity with molecular biology techniques&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of basic statistics, image and genomic data analysis tools&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The estimated base salary range for this role is $119,000 - $147,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior/Principal Research Associate, Cell and Tissue Biology

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;:&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an experienced and highly motivated Biomarker Senior Research Associate/Principal Research Associate to join the Biomarker Development Group and contribute to the discovery and validation of pharmacodynamic biomarker assays to support a wide range of clinical programs. Our group is responsible for developing biomarkers for programs in Oncology, Tissue Growth and Repair, Neuroscience and Metabolism. We are looking for a team-player with demonstrated experience in molecular and cellular biology and hands-on assay development.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Discover and validate pharmacodynamic biomarkers to support clinical development of drugs with novel mechanism of action utilizing pre-clinical models (&lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt;) and human specimens&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and qualify biomarker assays using various platforms (e.g.: MSD, ELISA, Luminex, Flow-Cytometry) to support early-stage clinical trials&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;BS or MS degree in immuno-oncology, immunology, cell biology, cancer biology, molecular biology, or a related field, with 4+ years of industry experience&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;Experience handling and processing human whole blood for PBMC and specific human immune cell isolation&lt;/li&gt;
&lt;li&gt;Proficient in cell culture, in vitro cell systems and primary cell culture&lt;/li&gt;
&lt;li&gt;Experience in biochemical methods (western blotting, enzyme assays, immunoprecipitation)&lt;/li&gt;
&lt;li&gt;Experience in immunoassay development on a variety of platforms (e.g MSD)&lt;/li&gt;
&lt;li&gt;Experience with analyzing phenotypic readouts by flow cytometry (multi-color flow, co-staining of surface and intracellular proteins)&lt;/li&gt;
&lt;li&gt;Proficient in data analysis (e.g FlowJo, FACS Diva, SpectroFlo, Prism, Spotfire)&lt;/li&gt;
&lt;li&gt;Experience in RNA techniques (isolation, qPCR)&lt;/li&gt;
&lt;li&gt;Self-motivated with a “can-do” attitude is required for success&lt;/li&gt;
&lt;li&gt;Able to plan, execute, and troubleshoot experiments independently&lt;/li&gt;
&lt;li&gt;Strong teamwork and communication skills&lt;/li&gt;
&lt;li&gt;Experience in single cell RNAseq and characterizing extracellular vesicles is a plus&lt;/li&gt;
&lt;li&gt;Must be willing to work onsite four days a week&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;The estimated base salary range for this role is $119,000 - $147,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.&amp;nbsp; As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;
&lt;h4&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/h4&gt;

Senior/Principal Research Associate, Biomarker Development

&lt;p&gt;&lt;strong&gt;Principal Data Scientist/Statistical Programmer&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.&lt;/p&gt;
&lt;p&gt;We are seeking to recruit a Principal Scientist for the Clinical Data Science / Statistical Programming Group with experience supporting drug development, medical device, or clinical study projects; and has excellent statistical programming and problem-solving skills to support our clinical development programs. The ideal candidate will be able to function as a leader and individual contributor, will take the initiative to stay current on technologies and methods, come up with innovative solutions to challenging problems, and work with Biometrics management to help set the overall strategic direction of the group.&amp;nbsp; As a member of the Biometrics team at Denali Therapeutics, the candidate will work closely with clinical study team members and biometrics colleagues.&amp;nbsp; The candidate will have the opportunity to help shape Denali’s data and programming infrastructure, gain an in-depth understanding of drug development in a fast-moving industry environment and subject domain knowledge in the field of neurodegeneration.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Primary Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Represent data science on study execution teams. Study execution support will include creation of datasets, data visualizations or summary reports to support internal decision making and regulatory interactions (IND/CTA filings, annual safety reporting, etc.).&lt;/li&gt;
&lt;li&gt;Providing input for study data standardization plan, study protocols, statistical analysis plans, randomization specifications, and clinical study reports.&lt;/li&gt;
&lt;li&gt;Partner with Clinical Data Management to provide input for case report form design, data review plans, and external data transfer specifications.&lt;/li&gt;
&lt;li&gt;Collaborate with study team and external functions (e.g., CROs, specialty lab vendors, clinical development partners, etc) to ensure meeting project timelines and goals&lt;/li&gt;
&lt;li&gt;Provide technical leadership in designing, developing, and validating of clinical trial data for regulatory submissions in CDISC (SDTM, ADaM, Define.xml, SDRG, ADRG, aCRF and P21 checks, etc..) format&lt;/li&gt;
&lt;li&gt;Develop and manage reusable code for interactive data visualization and analytics tools for reporting and exploratory analysis.&lt;/li&gt;
&lt;li&gt;Lead and/or support the biometrics team in efforts to build, maintain, and continuously improve an SAS/R infrastructure that is suitable for regulatory submission work.&lt;/li&gt;
&lt;li&gt;Curate tidy analysis data for use with statistical reporting code and analytics applications.&lt;/li&gt;
&lt;li&gt;Provide programming support to prepare regulatory requested analyses and help submission team in quick turnaround in response to regulatory agencies.&lt;/li&gt;
&lt;li&gt;Perform programmatic review of analysis datasets and TLFs generated by programming teams, ensure high quality of deliverables, conduct Integrated Summary of Efficacy (ISE)/Integrated Summary of Safety (ISS)&lt;/li&gt;
&lt;li&gt;Work with the biometrics team to establish innovative processes to ensure high data quality, reporting of analysis results, and analysis reproducibility.&lt;/li&gt;
&lt;li&gt;Support data science and biometric functional initiatives. Lead/participate in departmental or cross-functional working groups and process improvement activities.&lt;/li&gt;
&lt;li&gt;Effectively interact with external programming resources, including contributing to development and/or review of contract specifications and feedback on performance.&lt;/li&gt;
&lt;li&gt;Act as mentor and train data scientists/statistical programmers regarding programming techniques, project management, and implementation of standards.&lt;/li&gt;
&lt;li&gt;Contribute to the recruitment and retention of both permanent and contract talent.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Must Have Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;At a minimum, a bachelor’s degree in Statistics, Biostatistics, Data Science, Mathematics, or related field.&lt;/li&gt;
&lt;li&gt;8+ years of experience as a Statistical Programmer on a Biotech/Pharma Clinical Development Biometrics Team or with a similar team and experience supporting drug development, medical device development, or intervention studies.&lt;/li&gt;
&lt;li&gt;Thorough understanding of the clinical drug development process (clinical trials Phase I-IV).&lt;/li&gt;
&lt;li&gt;Prior direct report management experience including mentoring, training, and enabling staff to grow professionally.&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Extensive applied experience with SDTM and ADaM CDISC data standards and health authority submission of data; or familiarity and exposure to CDISC standards (i.e., SDTM, ADaM) for regulatory submissions and willingness to become a subject matter expert in applying these standards.&lt;/li&gt;
&lt;li&gt;Knowledge of regulatory requirements concerning electronic submission standards and experience in delivering one or more submissions to regulatory authorities globally.&lt;/li&gt;
&lt;li&gt;In depth knowledge of statistical programming languages such as SAS (including Base, STAT, Macro and GRAPH), R (including tidyverse, RMarkdown, Shiny, htmlwidgets, development of R packages), and common technology platforms&lt;/li&gt;
&lt;li&gt;Demonstrated experience in creating compelling data visualizations to help teams make correct data driven decisions and effectively communicating results to team members.&lt;/li&gt;
&lt;li&gt;Able to demonstrate a solid understanding of statistical principles and methods used in clinical study reports or scientific publication analyses.&lt;/li&gt;
&lt;li&gt;Experience applying software development concepts, and proficiency in using Git/GitHub for collaboration and versioning of operational, robust, and well documented code.&lt;/li&gt;
&lt;li&gt;Demonstrated ability to effectively lead projects and collaborate cross-functionally.&lt;/li&gt;
&lt;li&gt;Able to work in a Linux/Unix environment (including shell scripting).&lt;/li&gt;
&lt;li&gt;Working knowledge of relevant FDA, EMA, PMDA, HC and ICH guidelines and regulations.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Prior work experience with pharmacokinetic data and the neuroscience field,&lt;/li&gt;
&lt;li&gt;proficiency in languages or tools other than SAS (e.g., R, Python, and Java, Shiny, Markdown, Unix/Linux, and git),&lt;/li&gt;
&lt;li&gt;Experience with Amazon Web Services and cloud infrastructure, and experience with applying machine learning techniques.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;Salary Range: $167,000 to $203,667. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at &lt;a href=&quot;https://www.denalitherapeutics.com/careers&quot; target=&quot;_blank&quot;&gt;https://www.denalitherapeutics.com/careers&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;*This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-SC1&lt;/p&gt;

Principal Data Scientist/Statistical Programmer (Remote)

&lt;div&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;Imaging based phenotyping of in-vitro biology is at the heart of insitro’s efforts to accelerate drug development. At insitro we use machine learning to derive clinically relevant insights from rich datasets generated in-house.&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;As a machine learning computer vision applied scientist&amp;nbsp; with emphasis on microscopy you will develop ML methods to process and analyze images from multiple microscopy modalities. You will integrate our in-vitro imaging data to modalities like transcriptomics and human cohort data in order to extract insights about disease mechanisms. You will be part of a cross-functional team of life scientists, bioengineers and machine learning scientists that strive to identify therapeutic targets and develop drugs of high efficacy and low toxicity.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;You will be joining a vibrant biotech startup that has long-term stability, due to significant funding, and is in a high growth phase. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in computer vision, machine learning, computer science or a related discipline, or equivalent practical experience (e.g., a Master’s degree plus 2 years of relevant industry experience)&lt;/li&gt;
&lt;li&gt;Effective in team-based software design and development&lt;/li&gt;
&lt;li&gt;Demonstrated ability to use and develop cutting edge methods for analyzing imaging data&lt;/li&gt;
&lt;li&gt;Extensive hands on experience working with microscopy data or similar biomedical or biophysical imaging modalities&lt;/li&gt;
&lt;li&gt;Experience developing models for diverse computer vision tasks (e.g. segmentation, recognition, classification, domain adaptation) including using modern deep learning frameworks (PyTorch, TensorFlow, Keras, etc)&lt;/li&gt;
&lt;li&gt;Strong programming skills in Python, including processing TB-scale image datasets&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions&lt;/li&gt;
&lt;li&gt;Passion for making a difference in the world&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Nice to Have&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Demonstrated ability to write software in a team, industry experience or&amp;nbsp; substantial involvement with open source projects.&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience modeling with video or imaging time-series datasets&lt;/li&gt;
&lt;li&gt;Experience building infrastructure for image preprocessing&lt;/li&gt;
&lt;li&gt;Experience with microscopy data acquisition&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Some understanding of image formation models (Fourier optics)&lt;/li&gt;
&lt;li&gt;Familiarity with cloud computing services (e.g., AWS or GCP)&lt;/li&gt;
&lt;li&gt;Experience with database languages (e.g., SQL)&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Publication record of meaningful contributions to high-quality work in relevant computer vision, clinical ML, or biomedical venues&lt;/li&gt;
&lt;li&gt;Proficiency in C++/OpenCV/CUDA, or other compiled, statically-typed languages and related computer vision/graphics libraries&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Compensation &amp;amp; Benefits at insitro&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Our target starting salary for successful US-based applicants for this role is $160,000 - $215,000. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;the level at which they are actually hired,&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;market demand, business needs, and internal parity. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We may also adjust this range in the future based on market data.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In addition, insitro also provides our employees:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;401(k) plan with employer matching for contributions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Open, flexible vacation policy&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Paid parental leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Quarterly budget for books and online courses for self-development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support to occasionally attend professional conferences that are meaningful to your career growth and development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;New hire stipend for home office setup&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Monthly cell phone &amp;amp; internet stipend&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite baristas and cafe with daily lunch and breakfast&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite fitness center&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Commuter benefits&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;div class=&quot;section page-centered&quot;&gt;
&lt;p&gt;&lt;strong&gt;About insitro&lt;/strong&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;div class=&quot;section page-centered&quot;&gt;
&lt;div&gt;insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&amp;amp;D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at&amp;nbsp;&lt;a class=&quot;postings-link&quot; href=&quot;http://www.insitro.com/&quot;&gt;www.insitro.com&lt;/a&gt;.&lt;/div&gt;
&lt;/div&gt;&lt;/div&gt;

Lead/Senior ML Scientist for Computer Vision, Microscopy 

&lt;div&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;Key to insitro’s approach to rethinking drug development is leveraging disease models, genetics, and clinical datasets to link in vitro and cellular phenotypes with patient outcomes.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;Imaging based high content phenotyping is at the heart of insitro’s efforts to characterize and quantify sophisticated patient datasets. Our goal is to use machine learning to characterize image content and patient state from clinical imaging modalities such as pathology images in clinical cohorts.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;As a machine learning / computer vision researcher with an emphasis on clinical data, your focus will be to develop innovative ML approaches to analyze and integrate large-scale medical imaging datasets such as histopathology, MRI, and other clinical imaging modalities from randomized clinical trials, electronic health records/PACS, national biobanks, and other sources. You will also work with colleagues to integrate those data with associated clinical, genetic, or other variables. Via this collaborative effort, you will have the opportunity to contribute to developing models for understanding patient disease state and progression, predicting patient outcomes, and identifying therapeutic targets and developing drugs that have high efficacy and low toxicity.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;Your work will involve the development and deployment of cutting edge methods in both classical computer vision and deep learning. The data we deal with will require addressing challenges such as distribution shift, such as hospital site variability in histology stain characteristics, data missingness, class imbalance, and small sample sizes, among other unique challenges. You will need to develop fit-for-purpose approaches that utilize methods such as self-supervised learning, multi-task learning, few-shot learning, and more. You will work in collaboration with the software engineering team to develop these methods as robust, reusable platform components that can be deployed on large-scale datasets in a portable way.&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;You will be joining a vibrant biotech startup that has long-term stability, due to significant funding, and is in a high growth phase. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;This role is preferably based in the San Francisco Bay Area or Boston, but we are open to discussing other locations in the United States and the United Kingdom.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in computer vision, machine learning, computer science, clinical machine learning or a related discipline, or equivalent practical experience (e.g., a Master’s degree plus 2 years of relevant industry experience)&lt;/li&gt;
&lt;li&gt;Experience developing models for diverse computer vision tasks (e.g. segmentation, recognition, classification, domain adaptation) including using modern deep learning frameworks (PyTorch, JAX, Keras, etc)&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience working with biomedical imaging modalities&lt;/li&gt;
&lt;li&gt;Experience with modern representation learning approaches such as self-supervised learning, transfer learning, multi-modal modeling, few-shot learning, and more&lt;/li&gt;
&lt;li&gt;Strong programming skills in Python, including processing TB-scale image datasets using Linux/Bash&lt;/li&gt;
&lt;li&gt;Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions&lt;/li&gt;
&lt;li&gt;Passion for making a difference in the world&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Nice to Have&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Experience building infrastructure for clinical image dataset preprocessing&lt;/li&gt;
&lt;li&gt;Experience with real-world challenges of clinical data analysis, including working with clinical datasets such as EHR/PACS or clinical trial data and interactions with clinicians&lt;/li&gt;
&lt;li&gt;Demonstrated ability to write software in a team, through industry experience or substantial involvement with open source projects&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Some understanding of human physiology or disease biology (especially cancer, metabolism, or neurodegeneration)&lt;/li&gt;
&lt;li&gt;Publication record of meaningful contributions to high-quality work in relevant computer vision, clinical ML, or biomedical venues&lt;/li&gt;
&lt;li&gt;Familiarity with cloud computing services (e.g., AWS or GCP)&lt;/li&gt;
&lt;li&gt;Proficiency in C++/OpenCV/CUDA, or other compiled, statically-typed languages and related computer vision/graphics libraries&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;
&lt;div&gt;&lt;strong&gt;Compensation &amp;amp; Benefits at insitro&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Our target starting salary for successful US-based applicants for this role is $160,000 - $215,000. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;the level at which they are actually hired,&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;market demand, business needs, and internal parity. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We may also adjust this range in the future based on market data.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In addition, insitro also provides our employees:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;401(k) plan with employer matching for contributions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Open, flexible vacation policy&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Paid parental leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Quarterly budget for books and online courses for self-development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support to occasionally attend professional conferences that are meaningful to your career growth and development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;New hire stipend for home office setup&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Monthly cell phone &amp;amp; internet stipend&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite baristas and cafe with daily lunch and breakfast&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite fitness center&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Commuter benefits&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;/div&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;div class=&quot;section page-centered&quot;&gt;
&lt;p&gt;&lt;strong&gt;About insitro&lt;/strong&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;div class=&quot;section page-centered&quot;&gt;
&lt;div&gt;insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&amp;amp;D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at&amp;nbsp;&lt;a class=&quot;postings-link&quot; href=&quot;http://www.insitro.com/&quot;&gt;www.insitro.com&lt;/a&gt;.&lt;/div&gt;
&lt;/div&gt;&lt;/div&gt;

Senior / Lead Computer Vision/Clinical ML Scientist

&lt;p&gt;&lt;strong&gt;Why join Freenome?&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To fight the war on cancer, Freenome has raised more than $1.1B from leading investors including a16z, GV (formerly Google Ventures), T. Rowe Price, BainCapital, Perceptive Advisors, RA Capital Management, Roche, Kaiser Permanente Ventures, and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&amp;nbsp;&lt;br&gt;&lt;br&gt;&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Are you ready for the fight? A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrive in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career. Freenomers are determined, patient-centric, and outcomes-driven. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. We are dedicated to advancing healthcare, one breakthrough at a time.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;br&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About this opportunity:&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is looking for an Associate Data Scientist who will be responsible for building data-driven solutions to challenges in multi-omic biomarker discovery projects. In this role, you will work closely with Data Scientists, Computational Biologists, Software engineers and Molecular Research Scientists to maintain data integrity and support R&amp;amp;D data management to make R&amp;amp;D digital assets findable, accessible, interoperable and reusable (FAIR). You will be responsible for improving and maintaining data pipelines that are critical for clinical lab operation and preanalytical data processing. You will also be responsible for building reports to help scientists to understand experimental data and to gain insights into our biospecimen inventory.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll do:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; Explore and extract insights from structured and unstructured data collected during preanalytical steps to improve sample handling practices.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; Improve and maintain data pipelines to process preanalytical and clinical data for machine learning applications.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; Improve and maintain the sample selection/grouping pipeline to Identify and model patient metadata, with applications in biomarker study design and execution.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; Create dashboards and presentations to effectively communicate detailed findings to diverse audiences. &lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Must haves:&lt;/strong&gt;&lt;strong&gt;&lt;br&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Bachelor’s or Master’s in a relevant, quantitative field such as life science, applied math, statistics, or data science with at least 1 year of industry experience. Life science background strongly preferred.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Strong technical abilities in relational database, database queries (i.e., SQL), data segmentation techniques, and applying ETL frameworks.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to program in a scientific programming language (e.g., Python), work in a Linux server-based environment, and perform appropriate statistical analyses.&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;A passion for innovation and tackling new areas of research.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proficiency in office tools such as google sheets and google doc.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Excellent written and verbal communication skills.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to haves:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with git version control.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with business intelligence tools such as Tableau or google data studio.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Benefits and additional information:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;The US target range of our&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; base salary&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; for new hires is $97,750 - $150,000&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;. You will also be eligible to receive pre-IPO equity, cash bonuses, and a full range of medical, financial, and other benefits dependent on the position offered.&amp;nbsp; Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several&amp;nbsp;&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page&amp;nbsp;&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;@ &lt;/span&gt;&lt;a href=&quot;https://careers.freenome.com/&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;https://careers.freenome.com/&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; for additional company information.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;law.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;color: #ecf0f1;&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;#LI-Remote&lt;/span&gt;&lt;/em&gt;&lt;/span&gt;&lt;/p&gt;

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