&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are currently seeking to recruit a talented Postdoctoral Scientist to join our Pathway Biology group to explore mechanisms of lysosomal dysfunction linked to Parkinson’s disease (PD).&amp;nbsp; Reporting to Anastasia Henry, the Postdoctoral Scientist will examine the molecular underpinnings of how variants in PD-linked proteins impact lysosomal function and lipid homeostasis and ultimately contribute to the pathogenesis of PD. The Postdoctoral Scientist will employ a cross-functional approach to work toward the ultimate goal of identifying novel potential targets for the treatment of PD.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform research in a dynamic and collaborative environment&lt;/li&gt;
&lt;li&gt;Collaborate with colleagues across diverse functional areas, including human genetics&lt;br&gt;and functional genomics, to achieve research goals&lt;/li&gt;
&lt;li&gt;Make detailed observations, analyze data, interpret results and communicate clearly&lt;/li&gt;
&lt;li&gt;Design and implement assays to probe lysosomal function and identify novel regulators&lt;/li&gt;
&lt;li&gt;Attend conferences, write and publish manuscripts in peer-reviewed journals&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Cell Biology, Biochemistry, Neuroscience or related fields&lt;/li&gt;
&lt;li&gt;Proficiency in a broad range of biochemical and cellular techniques including&lt;br&gt;mammalian cell culture and transfection, western blotting, and immunofluorescence&lt;/li&gt;
&lt;li&gt;Expertise in live-cell imaging and quantitative image analysis&lt;/li&gt;
&lt;li&gt;Experience in the field of membrane trafficking or lysosomal biology is highly desired&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills&lt;/li&gt;
&lt;li&gt;Creative thinker with a strong sense of responsibility and collaborative spirit&lt;/li&gt;
&lt;li&gt;Priority will be given to candidates with no or short (&amp;lt;1 year) prior postdoctoral&lt;br&gt;experience&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-BR1&lt;/p&gt;

Postdoctoral Scientist, Lysosomal Biology 

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is dedicated to developing breakthrough therapies for patients with neurodegenerative diseases through deep commitment to understanding degeneration biology and rigorously applying the principles of translational medicine. Denali is seeking a motivated Research Scientist to join our Biology Discovery group. This individual will develop and perform &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; cell-based assays to support novel therapeutic target identification and validation. The ideal candidate must be self-driven, organized and able to collaborate with multiple groups to support the lysosomal biology and glia biology teams.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work under supervision of Denali senior scientists to conduct research in a dynamic, highly-collaborative and fast-paced environment&lt;/li&gt;
&lt;li&gt;Support identification and validation of targets using &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt;&lt;/li&gt;
&lt;li&gt;Maintain detailed records of the experimental procedures and data in accordance with Denali policy&lt;/li&gt;
&lt;li&gt;Communicate experimental designs, protocols, and data to cross-functional teams and collaborators&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A Bachelors or Masters degree with at least 3 years of pharmaceutical/biotech experience in biology, neuroscience, cell biology, or related field&lt;/li&gt;
&lt;li&gt;Extensive experience in molecular, biochemical, and cellular techniques, including mammalian cell culture and transfection, western blotting, immunohistochemistry, ELISA and qPCR&lt;/li&gt;
&lt;li&gt;Expertise in microscopy and image analysis is preferred&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills and enjoy collaborative environments&lt;/li&gt;
&lt;li&gt;Creative and inquisitive thinker who is eager to explore and learn new skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;#LI-BR1&lt;/p&gt;

Research Scientist, Discovery Biology

&lt;p&gt;Job Post Goes Here&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;About Twist Bioscience&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.&lt;/span&gt;&lt;/p&gt;

Staff Data Scientist, DNA Products

&lt;p&gt;&lt;strong&gt;About Freenome&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the Role&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;At Freenome, you will help develop the assay technologies used to analyze patient samples and contribute to our mission of early detection and intervention in human disease. As a Development Scientist, you will provide expertise in next-generation-sequencing (NGS)-based analyses of DNA and RNA. Starting with a prototype assay, you will contribute to developing, optimizing, and validating clinical-grade assays to measure complex, blood-based analytes (e.g., whole-genome sequencing of cfDNA). You will work closely with multiple teams including research team, process engineers, computational science team, and clinical operations to develop and optimize the assays in a regulated, high-throughput environment as well as identify ways to rapidly iterate and improve on existing methods to evaluate technologies that can enhance our end-to-end test performance.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Your contribution:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Apply expert knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA, RNA, protein, and other bioanalyte including genome-wide and targeted approaches&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Develop assays by converting manual prototypes into optimized, high-throughput validated assays&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Identify workflow and protocol improvement by analyzing and developing method data&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with computational biologists and software engineers to build analysis pipelines and to integrate new molecular technologies into analytical workflows.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with clinical laboratory members to transition development protocols into production, including automation, validation experiments, and SOP development.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Present data in cross functional teams&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Apply your knowledge of Design Control, Quality Management and Risk Mitigation to product and study design.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Document product development requirements and author study protocols and reports&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Your background, perspective and experience:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD (or equivalent industry experience) in molecular biology, biochemistry, genetics, chemistry, or a related field&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience in molecular diagnostic assay development, preferably in an FDA regulated environment for IVD under design control.&amp;nbsp; LDT/CLIA and CE-IVD experience will also be considered.&amp;nbsp; PMA submission experience desired.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Broad, expert-level knowledge of NGS assays for DNA and RNA, including general nucleic acid biochemistry as well as specific optimizations for different applications, sequencing platforms, and analytes.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proven track record of establishing new methods for NGS-based measurements of biology (*-seq) that go beyond kitted assays&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Familiarity with programing in a scientific programming language (e.g., Python or R) and perform bioinformatics analyses to enable experimental iteration independent of external support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to design for automated platforms in plate-based, low-volume formats and/or microfluidics and experience working with automated liquid handlers.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Biological understanding of human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Hands-on proficiency in managing technology transfer requirements, including guard-banding, stability studies, and in-process quality control.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Clear communications skills and ability to work with team members in the same and adjacent disciplines&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;COVID safety:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;As a condition of employment, you agree to know and comply with our COVID-19 vaccination policy requiring all employees who work on-site and/or attend work-related events to be fully vaccinated and to receive a COVID-19 booster once eligible. Company employees working on-site are required to be fully vaccinated for COVID-19 and to receive a COVID-19 booster once eligible, unless a reasonable accommodation is approved or as otherwise required by law. Absent a reasonable accommodation or legal exception, you agree to provide proof of your vaccination status and to be fully vaccinated by your first day on-site, in accordance with our policy.&amp;nbsp; If you are currently eligible for a COVID-19 booster, you also agree to provide proof of having received a booster.&amp;nbsp; If you are not yet eligible for a COVID-19 booster, you must provide proof of receiving a booster within two weeks of becoming eligible.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Funding&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We have raised more than $1.1B from leading investors including Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Freenomers&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrives in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenomers are technical, creative, visionary, grounded, empathetic and passionate. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. Freenomers are some of the most talented experts in their fields, joining together to advance healthcare, one breakthrough at a time.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Benefits include but are not limited to:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Competitive compensation&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Pre-IPO equity&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Flexible PTO (exempt) and generous PTO (non-exempt)&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Comprehensive health coverage, including medical, dental, and vision&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Wellness and mental health resources, including Employee Assistance Programs (EAPs), Paid maternity and paternity leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;401(k) plan&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;$250.00 new hire stipend to enhance your home office experience&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Plus, a variety of other perks, including pre-tax commuter benefits, two paid volunteer days per year, pet insurance, and additional discounts&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;# # #&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Notice to agencies&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;:&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Our in-house Talent Acquisition Team manages all employment opportunities at Freenome.&amp;nbsp; Agencies and independent recruiters must be approved as a vendor by Freenome’s Talent Acquisition team before submitting candidates to any Freenome employee.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We do not accept unsolicited resumes or biographies from agencies under any circumstances. Any unsolicited resumes sent to Freenome, including those sent to a Freenome email address or directly to Freenome employees, will be considered Freenome property. Freenome will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume. Freenome will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Please do not contact Freenome employees directly. Compliance with this request will impact our decision to work with you.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;###&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;#LI-Remote, #LI-Onsite, #LI-Hybrid&lt;/span&gt;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;

(Senior) Development Scientist - IVD Pre-analytics

&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is continuing to build a leading, innovative Discovery organization that will strongly contribute to the discovery and development of novel therapeutics for neurodegenerative diseases. We are currently seeking excellent candidates to join our Discovery team based at our headquarters in South San Francisco, California.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role will support Denali’s expanded large molecule biotherapeutics efforts with the goal of identifying novel therapeutics for the treatment of neurodegenerative diseases. Accordingly, we seek candidates with experience in generating challenging or unprecedented proteins and protein complexes. The successful candidate will be responsible for leading the biochemical characterization of large molecule biotherapeutics including guiding the development of robust and scalable purification processes and fit-for-purpose analytics. Close collaboration with protein engineers, pharmacologists, biologists &amp;amp; CMC teams will be essential to success.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Design, implement &amp;amp; optimize purification approaches for enzymes, enzyme-Fc fusions and difficult-to-express protein complexes&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Purify enzymes from cell culture (CHO/293) by column chromatography (using AKTA systems)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and troubleshoot protein purification processes using chromatographic methods (AKTA system)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analyze proteins using standard protein characterization methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Lead troubleshooting efforts for protein expression and purification processes&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support hit generation and lead optimization activities for multiple large molecule targets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Assist in identifying lead therapeutic candidate molecules based on purification &amp;amp; analytical workflows&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Think creatively about ways to integrate novel protein modalities with our BBB-crossing technologies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Actively contribute to project teams and work effectively across functional teams to help advance programs&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Successful candidates will meet most of these criteria:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD in Biochemistry or related scientific discipline with 3+ years in biotech/biopharma industry or M.Sc/B.Sc. with ≥6 years of experience in biotech/biopharma&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in protein biochemistry and enzymology, as reflected in authorship on peer-reviewed publications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-depth experience in the purification of challenging proteins, complexes and fusions proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive knowledge and hands-on experience with large molecule protein purification workflows including multiple chromatographic methods (immunoaffinity, IEC, HIC, SEC)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in molecular biology, including plasmid design&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent oral, presentation and written communication skills are required&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Creative thinker with a strong sense of r&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;esponsibility and a desire to collaborate in an exciting and fast-paced research environment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment.&amp;nbsp; We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;#LI-AS1&lt;/p&gt;

Senior Scientist, Biochemistry (Protein Technologies) 

&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is continuing to build a leading, innovative Discovery organization that will strongly contribute to the discovery and development of novel therapeutics for neurodegenerative diseases. We are currently seeking excellent candidates to join our Discovery team based at our headquarters in South San Francisco, California.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The candidate for this senior position will be responsible for leading the production efforts of large molecule biotherapeutics, across the discovery-to-development stages, to support the identification and characterization of novel therapeutics for the treatment of neurodegenerative diseases.&amp;nbsp; Under minimal supervision, the &lt;/span&gt;&lt;strong&gt;Principal Scientist&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; for this position will independently design and implement production and purification strategies for complex engineered antibodies, Fc-fusions and bioconjugated therapeutics.&amp;nbsp; Working with multiple groups across Denali, he/she will generate highly characterized proteins, from the milligram to gram scale, to enable &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vitro &lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;and &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vivo&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; studies and to support development efforts.&amp;nbsp; You will be expected to design, perform and oversee experiments, mentor colleagues, analyze and interpret results, coordinate appropriate CRO activities (including both routine and complex protein production), organize and carefully document results, and communicate findings.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We seek candidates with extensive experience in generating antibodies, antibody-drug conjugates (or bioconjugations), and/or engineered Fc-fusions, across the discovery-to-development stages.&amp;nbsp; Close collaboration with protein engineers, pharmacologists, biologists &amp;amp; CMC teams will be essential to success.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Design, implement &amp;amp; optimize purification and production strategies for large molecule biotherapeutics, including engineered antibodies (and other IgG-like molecules), bioconjugations and engineered Fc-fusions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Purify large molecule therapeutics from cell culture (&lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;i.e. &lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;CHO/293) by column chromatography using AKTA systems, and design and transition to scalable processes, up to gram quantities&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Lead troubleshooting efforts for protein expression and purification processes&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analyze proteins using standard protein characterization methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Guide the development and implementation of fit-for-purpose analytics that support development&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support hit generation and lead optimization activities for multiple large molecule targets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Assist in identifying lead therapeutic candidate molecules based on purification &amp;amp; analytical workflows&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Think creatively about ways to integrate novel protein modalities with our blood-brain-barrier (BBB)-crossing technologies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Actively contribute to project teams and work effectively across functional teams to help advance programs to development&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Successful candidates will meet most of these criteria:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD in Biochemistry or related scientific discipline with 12+ years in biotech/biopharma industry or M.Sc/B.Sc. with ≥15 years of experience in biotech/biopharma&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive experience in biotherapeutic protein production and biochemistry, as reflected in authorship on peer-reviewed publications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in the generation and development of antibody-drug conjugates and/or other bioconjugated materials&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-depth experience in the purification of challenging and/or engineered proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with CROs for the production of routine and complex proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive knowledge and hands-on experience with large molecule protein purification workflows including multiple chromatographic methods (immunoaffinity, IEC, HIC, SEC)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in molecular biology, including construct design&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent oral, presentation and written communication skills are required&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Creative thinker with a strong sense of r&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;esponsibility and a desire to collaborate in an exciting and fast-paced research environment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment.&amp;nbsp; We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;#LI-AS1&lt;/p&gt;

Principal Scientist, Biochemistry (Protein Technologies) 

&lt;div class=&quot;content-intro&quot;&gt;&lt;p&gt;EVERY™, based in South San Francisco, is a leading VC-backed food tech ingredient company using precision fermentation to create animal proteins without the animal for the global food and beverage industry. Originally founded as Clara Foods in 2014, EVERY™ rebranded in 2021 to better convey its vision to bring animal-free proteins to everyone, everywhere. EVERY™ is a team of passionate change makers who are reimagining the factory farm model with a kinder, more sustainable alternative. Leveraging precision fermentation to produce hyper-functional and one-to-one replacement proteins from microorganisms, EVERY™ is on a mission to decouple the world’s proteins from the animals that make them.&lt;/p&gt;
&lt;p&gt;We are a passionate, determined, (and fun!) team with a vital objective, and we&#x27;re on the lookout for like-minded people to join our mission. Sound like you?&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;Data Scientist Intern&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Reports to&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: Director of Data Science &amp;amp; Technologies&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;FLSA Status&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: Non-exempt&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Location&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: South San Francisco (Fully remote until further notice)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;You are excited to work with others in applying machine learning, statistics, data visualization, and software engineering to solve complex problems in biology, food science, operations, and sustainability. You are looking forward to participating in the full journey of your work from initial exploration with internal users to integration in a production system, conducting experiments and growing infrastructure along the way. You may or may not be fluent in all of these different areas but are eager to build your knowledge broadly while working with many other parts of the company.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Like others on the team, you will shepard your high impact work from conception to release:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Co-designing data science solutions with other teams and partners.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experimenting in complex problems and storytelling in highly dimensional datasets, often using machine learning or data visualization.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Participating in creating conduits for data that unite different teams together.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Collaborating on software-based tools around your work.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Skills and Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We are building a team of diverse skills and backgrounds so encourage folks to apply even if they don’t have all of the following desired skills but want to work with many different tools and technologies:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Python programming (flask, fastapi, or django a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Data visualization (Tableau, d3, Processing, or p5.js a plus) and / or machine learning-based modeling (experience in scikit and tensorflow a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Working with SQL databases (postgres a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Statistical understanding (experience in scipy or statsmodels a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Prior work or desire to grow in food, bioinformatics, and operations research.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Prior experience with user / human-centered design a plus but not required.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Unit testing and CI/CD a plus&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Note: though most employees are currently working from home, you will be expected to be available during regular business hours (9am to 5pm Pacific Time) and, periodically, during pre-scheduled times outside regular business hours.&lt;/span&gt;&lt;/p&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;p&gt;&lt;strong&gt;What EVERY™ can Offer for Full-Time Positions:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Generous benefits package; 100% medical, dental, and vision employee coverage, 401k matching, and stock&lt;/li&gt;
&lt;li&gt;Optional benefits; FSA, HSA, Commuter, Pet Care, and additional life insurance&lt;/li&gt;
&lt;li&gt;Flexible PTO and 14 paid company holidays per year&lt;/li&gt;
&lt;li&gt;Free parking, unlimited gym access, lounge, mini-golf patio, yoga and fitness classes onsite&lt;/li&gt;
&lt;li&gt;Unlimited supply of sparkling water, granola bars, snacks, local coffee and tea&lt;/li&gt;
&lt;li&gt;Weekly virtual happy hours &amp;amp; lunches&lt;/li&gt;
&lt;li&gt;Monthly all-hands meetings and 1:1 with CEO and leadership&lt;/li&gt;
&lt;li&gt;Close to South San Francisco BART and CalTrain stations, including free shuttle service&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;EVERY™ is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Legal authorization to work in the U.S. is required.&amp;nbsp; We are not able to sponsor individuals for employment visas for this job.&amp;nbsp;&lt;/em&gt;&lt;em&gt;In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.&lt;/em&gt;&lt;/p&gt;&lt;/div&gt;

Data Scientist Intern

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly motivated Associate Scientist to join our Antibody Discovery and Protein Engineering group and contribute to the discovery and development of novel biotherapeutics for the treatment of neurodegenerative diseases. You will support the discovery, engineering, and characterization of therapeutic lead antibodies to maximize their therapeutic potential.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;Conduct high-throughput SPR binding screens to support antibody discovery, engineering, and development&lt;/li&gt;
&lt;li&gt;Develop and optimize biochemical and biophysical assays to interrogate protein: protein interactions, including SPR (Biacore), BLI (Octet), and other related techniques&lt;/li&gt;
&lt;li&gt;Communicate results within the Biosensors group and to cross-functional project teams&lt;/li&gt;
&lt;li&gt;Conduct data analysis and maintain compliance to good record keeping (ELN)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Master’s degree and 1+ year bioengineering, biochemistry, biophysics, or related discipline and industry experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Bachelor’s degree and 3+ years bioengineering, biochemistry, biophysics, or related discipline and industry experience&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with biochemistry techniques including protein quantitation, protein purification, and/or biophysical/biochemical assays&lt;/li&gt;
&lt;li&gt;General understanding of protein and antibody biophysical characterization methods&lt;/li&gt;
&lt;li&gt;Hands-on experience with Biacore T200, Biacore 8000, Octet Red, Kinexa, and/or microITC instruments&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Associate Scientist,Biophysical Characterization

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The successful candidate will join a multi-disciplinary science team with a focus on developing high throughput technology to develop novel strategies to characterize protein-protein interactions. The ideal candidate must be highly innovative, motivated, detail-oriented, work autonomously with a variety of experimental techniques, and be comfortable presenting results to cross-functional teams.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position requirements&lt;/strong&gt;:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in molecular biology, biochemistry, or related discipline plus 0-4 years postdoc experience or equivalent experience working in biopharma/biotech sectors&lt;/li&gt;
&lt;li&gt;Proficient with various protein display systems such as yeast, bacteria, phage and mRNA display. Skilled in library creation, selection, and enrichment analysis.&lt;/li&gt;
&lt;li&gt;Experience with high-throughput automated protein (especially antibody) expression and purification&lt;/li&gt;
&lt;li&gt;Experience with antibody characterization and engineering&lt;/li&gt;
&lt;li&gt;Hands-on experience with investigating protein-protein interactions, ability to generate biochemical/biophysical data with SPR, Octet, ITC, FRET assays&lt;/li&gt;
&lt;li&gt;Accountable, meticulous with attention to detail, and able to multitask&lt;/li&gt;
&lt;li&gt;Strong teamwork and proactive communication skills&lt;/li&gt;
&lt;li&gt;Self-motivated and able to work independently in a cross-functional team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Experience with the following is a bonus:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience using evolutionary approaches to optimize protein function&lt;/li&gt;
&lt;li&gt;Background with structural biology approaches such as cryo-EM, X-ray crystallography, SAXS, HDX-MS, etc.&lt;/li&gt;
&lt;li&gt;Basic understanding of machine learning for structure prediction.&lt;/li&gt;
&lt;/ul&gt;

Scientist, Biochemistry

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;In anticipation of the Company’s growth plans, Denali Therapeutics is seeking a Scientist focusing on drug discovery research and mechanistic biology related to neurodegenerative diseases. Reporting to a Senior Director and Staff Scientist, the Scientist will perform translational research, with a focus on developing and validating biochemical and cell-based assays to explore mechanisms of neurodegeneration and support therapeutic development.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform research in a dynamic and collaborative environment&lt;/li&gt;
&lt;li&gt;Design and implement experiments to investigate disease mechanisms and support drug candidate selection&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Evaluate therapeutic candidates using biochemical assays, cell-based assays, and in vivo studies&lt;/li&gt;
&lt;li&gt;Make detailed scientific observations, analyze data, interpret, and present results&lt;/li&gt;
&lt;li&gt;Collaborate with colleagues in Biology Discovery, Medicinal Chemistry, Protein Sciences, Pharmacology, DMPK, Project Management, CMC, Toxicology, Early Development and Clinical Sciences to develop innovative research and develop novel drugs&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;PhD in Biochemistry, Cell Biology or Neurobiology&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Master’s degree and 3+ years related scientific experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Bachelor’s degree and 6+ years related scientific experience&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Postdoc or industry experience in cell and/or neuronal cell biology&lt;/li&gt;
&lt;li&gt;Proficiency in a broad range of biochemical, molecular and cellular techniques including: Western blotting, qPCR, transfection, RNA interference, immunofluorescence and/or live imaging techniques, immunohistochemistry, and quantitative image analysis&lt;/li&gt;
&lt;li&gt;Expertise in the culture of mammalian cell lines, primary cells, and/or iPSC-derived CNS cells&lt;/li&gt;
&lt;li&gt;Experience in the field of membrane trafficking, membrane biology or lipid metabolism/transport&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills&lt;/li&gt;
&lt;li&gt;Creative and inquisitive thinker who is eager to explore and learn new skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;

Scientist, Biology Discovery

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico is seeking a Senior Data Scientist to join our efforts in advancing novel therapies from target discovery to clinical development.&lt;/p&gt;
&lt;p&gt;Observations gleaned from the expansive high-dimensional phenotyping efforts of large human cohorts will increasingly advance our understanding of human aging and disease. Human genetics serves a critical role in linking observational phenotypes to their genetic roots but to act on such findings we often want a better understanding of the mechanism underlying a gene’s modulation of a phenotype of interest. Having such knowledge provides both a way to triage genetic associations that impinge on common pathways, but also could lead to other drug targets where natural variation may be highly constrained. To help fill this gap, an ideal candidate in this role will collaborate with our human genetics, translational and systems biology teams to develop and apply a systems genetics strategy for target discovery. This will involve representing genetic associations based on curated mechanistic pathways and exploring both experimental and statistical ways of testing how genetic perturbations are mechanistically transmitted.&lt;/p&gt;
&lt;p&gt;As a member of the Calico’s Computing team, you will work closely with a cross-functional group of computational biologists, machine learning engineers, data scientists, translational project leads, scientists, and biostatisticians to advance Calico’s pipeline. This role offers a unique opportunity to innovate at the leading edge of data science and quantitative systems pharmacology.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead the integration of our human genetics and systems biology platforms&lt;/li&gt;
&lt;li&gt;Plan, prioritize, and execute on high-value systems genetics projects aimed to support both target identification and indication selection&lt;/li&gt;
&lt;li&gt;Establish a process for testing genetic variants with experimental perturbations in cellular systems&lt;/li&gt;
&lt;li&gt;Communicate clearly and effectively in verbal, visual, and written form to stakeholders with varying levels of technical knowledge&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD. /MS and four years of work experience in a quantitative field such as Computer Science, Bioinformatics, Computational Biology, Statistics, Biological Sciences, Genomics, or equivalent preparation&lt;/li&gt;
&lt;li&gt;Experience in human genetics including analysis of rare and common variation, variant prioritization, analysis of multivariate phenotypes (e.g., colocalization) and causal inference&lt;/li&gt;
&lt;li&gt;Familiarity with modeling mechanistic pathways using molecular data&lt;/li&gt;
&lt;li&gt;Fundamental understanding of statistics and machine learning&lt;/li&gt;
&lt;li&gt;Fluency with Python (pandas, numpy, jupyter) and/or R (tidyverse)&lt;/li&gt;
&lt;li&gt;Track record of effective cross-functional collaboration&lt;/li&gt;
&lt;/ul&gt;

Senior Data Scientist - Systems Genetics

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is seeking a motivated laboratory-based Research Scientist to join our Translational Sciences group and support the company’s growing translational biology and biomarker needs. You will help implement biomarker assays for preclinical target engagement studies by working in close collaboration with colleagues in other teams such as In Vivo, Research, Development Sciences, and Clinical Development. You will also contribute towards discovery and development of novel biomarkers for target engagement assessment.&amp;nbsp;You will focus on diseases relevant to lysosomal dysfunction and lysosomal pathways.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work under supervision of Denali senior scientists to conduct biomarker research in a dynamic, highly collaborative, and fast-paced environment.&lt;/li&gt;
&lt;li&gt;Develop, design, and conduct &lt;em&gt;in &lt;/em&gt;vivo and &lt;em&gt;in &lt;/em&gt;vitro biomarker assays, including plate-based immunoassays and functional cell-based assays to measure readouts of lysosomal pathways and target engagement in preclinical and clinical biosamples.&lt;/li&gt;
&lt;li&gt;Coordinate with computational biologists and statisticians to analyze data and report quantitative results.&lt;/li&gt;
&lt;li&gt;Process human brain and biofluid samples for biomarker analysis including histological and biochemical assays.&lt;/li&gt;
&lt;li&gt;Create assay controls and reagents for internal and clinical use as needed.&lt;/li&gt;
&lt;li&gt;Archive, process, track, and test large sets of biosamples from preclinical and clinical studies.&lt;/li&gt;
&lt;li&gt;Work in collaboration with the automation team to analyze large biosample sets for preclinical and clinical studies.&lt;/li&gt;
&lt;li&gt;Maintain detailed records of the experimental procedures and data in accordance with Denali policy.&lt;/li&gt;
&lt;li&gt;Communicate experimental designs, assay validation plans, protocols, and biomarker data to cross-functional teams and collaborators.&lt;/li&gt;
&lt;li&gt;Stay up-to-date with research on biomarkers in neurodegenerative diseases and immunoassay technologies.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Bachelor’s degree and 2+ years pharmaceutical/biotech experience in biology, neuroscience, cell biology or immunology&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Extensive experience in molecular, biochemical, and cellular techniques including mammalian cell culture, western blotting, qPCR, FACS, tissue sectioning, or plate-based immunoassays. Experience with laboratory automation.&lt;/li&gt;
&lt;li&gt;Outstanding organizational and communication skills with the ability to work independently in a collaborative, dynamic and fast paced environment.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;

Research Scientist, Biomarkers

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;In anticipation of the Company’s growth plans, the Translational Sciences team at Denali Therapeutics is seeking a Biomarker Senior Scientist, who will help advance our neurodegenerative diseases programs through biomarker driven development. You will help drive the biomarker strategy for programs from Discovery to Development phase. In particular, the Scientist will perform translational research to evaluate biomarkers related to human patient samples, relevant preclinical animal and cellular models, with an emphasis on Alzheimer’s diseases and ALS/FTD.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform hands-on lab-based biomarker research in a dynamic and collaborative environment&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Lead the validation and transfer of preclinical biomarker assays for clinical use and execution of clinical biomarker analysis&lt;/li&gt;
&lt;li&gt;Contribute to the translational biomarker strategies, incorporating the latest research findings into applicable preclinical assays to advance research projects&lt;/li&gt;
&lt;li&gt;Develop and implement preclinical biomarker assays to assess both peripheral and CNS PD responses and to demonstrate preclinical proof-of-concept for small and large molecule drug candidates. Collaborate with DMPK Scientists on advanced PKPD modeling and data analyses&lt;/li&gt;
&lt;li&gt;Collaborate with clinical scientists to develop clinical biomarker strategies and establish biomarker-based decision-making criteria for development programs&lt;/li&gt;
&lt;li&gt;Data analysis and presentation at various team levels&lt;/li&gt;
&lt;li&gt;Write, edit, and review preclinical protocols, reports, and regulatory documents&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;PhD or PharmD in in Neuroscience, Cell Biology, Molecular Biology, Genetics, or related discipline and 4+ years of drug discovery and development biotech/pharmaceutical industry experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Master’s degree and 7+ years experience of drug discovery and development biotech/pharmaceutical industry experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Bachelor’s degree and 10+ years experience of drug discovery and development biotech/pharmaceutical industry experience&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with multiple assay platforms including MSD, ELISA, Quanterix, RNAseq, biochemical assays and mass spec related methodology&lt;/li&gt;
&lt;li&gt;Experience in the validation and optimization of research assays for use in a clinical setting, including an understanding of relevant quality and regulatory considerations&lt;/li&gt;
&lt;li&gt;Experience in handling large biomarker sample set and data analysis&lt;/li&gt;
&lt;li&gt;Attention to details and excellent record keeping&lt;/li&gt;
&lt;li&gt;Record of high-level publications focused on translational science, biomarkers, neurobiology, biochemistry, immunology, cell biology and translational models&lt;/li&gt;
&lt;li&gt;Excellent oral and written communication skills&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work effectively and collaboratively with other scientists on cross-functional projects teams&lt;/li&gt;
&lt;li&gt;Motivated, scientifically driven with grit and creativity for complex problem solving&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior Scientist, Biomarkers, Translational Sciences

&lt;p&gt;Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking to recruit a Research Scientist Computational Biologist to join our Discovery Genomics team to study the biology underlying neurodegeneration, with a particular focus on microglial biology and neuroinflammation. The successful candidate has broad expertise in the analysis of genomics-scale data, including bulk and single-cell transcriptomics, and will use them to deeply characterize cellular state and responses to therapeutic interventions&amp;nbsp;&lt;em&gt;in vitro&lt;/em&gt;&amp;nbsp;and&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;.&lt;/p&gt;
&lt;p&gt;You will join a group that values diversity of thought, continuous learning, and explores impactful ways of applying genomics to target and biomarker discovery. You are a strong communicator and will become a valued collaborator on cross-functional teams featuring e.g. Biologists, Chemists, Biomarker Scientists, Protein Engineers and Data Scientists.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Thoughtful design and reproducible analysis of genomics experiments, including e.g. single-cell / single-nuclei and spatial transcriptomics data, and distilling key takeaways.&lt;/li&gt;
&lt;li&gt;Identifying and applying best practices to genomics data collection, analysis &amp;amp; sharing, making datasets findable, accessible, interoperable and reusable (FAIR).&lt;/li&gt;
&lt;li&gt;Communicating your findings to specialists and non-specialists on cross-functional teams, and the broader research community through presentations and publications.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A BA / BS / MS in a relevant field, including — but not limited to — Computational Biology, Bioinformatics, Genomics, Biostatistics, etc. with 0 - 3 years of industry experience.&lt;/li&gt;
&lt;li&gt;Driven by the desire to make a positive impact on human health through rigorous collaborative science.&lt;/li&gt;
&lt;li&gt;Proven track record of analyzing high throughput genomics data as evidenced by high quality publications and/or conference talks in this area.&lt;/li&gt;
&lt;li&gt;Understanding of statistical approaches to the analysis of high-dimensional data. Previous experience in single cell transcriptomics is a plus.&lt;/li&gt;
&lt;li&gt;Extensive experience with a high-level data analysis language like R or Python. Knowledge of the Bioconductor software ecosystem and version control (e.g. GitHub) is a plus.&lt;/li&gt;
&lt;/ul&gt;

Research Scientist, Computational Biology 

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We want to better understand the biology that controls aging, and we want to use this knowledge to enable people to live longer, healthier lives. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We are not a traditional biotechnology company, nor are we an academic institution. We look to combine the best parts of both without the constraints of either.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; We are asking difficult questions about how we age and the diseases associated with aging. To find answers requires a long-term perspective, a relentless focus on understanding the basic biology of aging, utilizing or inventing state-of-the-art technology, enlisting advanced computing capabilities and working collaboratively within skilled, multifunctional teams.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is inviting applications from quantitative and experimental biologists to join our cell senescence and inflammation studies. How inflammation arises during aging, at the cellular and molecular level, and how it produces systemic effects on organismal aging is not well understood, but this information is critically important for the development of interventions to slow the aging process.&amp;nbsp; We believe that this goal can be realized through mammalian cell and molecular biology and powerful computational data analysis.&amp;nbsp; The ideal candidate has a keen analytical mind, a passion for understanding and slowing the aging process, and has an ability to combine molecular and cellular bench science with computational analysis to reach this goal. We practice team science, and we hope to find someone excited to combine his or her unique skills with those of other team members to rapidly advance the science of age-dependent inflammation and its translation to the clinic.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ph.D. in computational or cell biology or a related quantitative discipline.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience analyzing functional genomics data (RNA-seq, ATAC-seq, etc.)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Laboratory experience with mammalian cell culture or primary cell systems&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Laboratory experience with molecular biology and gene expression&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Track record of productivity and effective collaboration&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent verbal and written communication skills&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to have:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with yeast, worm, fly or mouse genetics, including genetic mosaic analysis&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Understanding of developmental biology&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Skills in microscopy&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Postdoctoral experience&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;

Scientist/Sr. Scientist/Computational Biologist, Inflammation and Aging

&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;SENIOR/RESEARCH SCIENTIST, PROTEOMICS BIOMARKER &lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;About the Role&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;At Freenome, our goal is to improve patient outcomes by pioneering the next-generation of blood tests for early and accurate disease detection using our combined multi-omics and machine learning platform. As a (Senior) Research Scientist in Proteomics, you will contribute to the program’s technical base by creating and optimizing new assays and workflows for protein biomarker discovery (including mass spectrometry and immunoaffinity approaches), and to the program’s scientific base by elevating our understanding of the biological context of these assay signals in cancer. In this role, you will lead projects to evaluate emergent technologies that have the potential to improve our diagnostic tests, collect and analyze proteomics data for biomarker discovery, and augment existing multi-omic models with novel signals you discover. You will also work closely with computational biologists and machine learning scientists to provide biological and technical insights, and to provide new data sources to enhance ongoing computational research projects.&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;How you’ll contribute:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Develop and employ novel assays to discover and quantify protein biomarkers in clinical samples.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Investigate the biological origin of blood-based biomarkers by performing detailed characterization of cell-free material, tumor tissues, and immune compartments.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Identify and test new proteomics technologies at pilot scales, and evaluate opportunities to integrate them into Freenome’s multiomics platform and products.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Refine existing proteomics assays by characterizing assay performance and implementing workflow and protocol improvements (including biofluid sample collection, protein extraction and depletion, and quantitation on discovery or targeted platforms).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Drive biomarker discovery studies that leverage both in-house generated datasets and published reference databases.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with computational biologists and software engineers to build analysis pipelines that appropriately integrate new molecular technologies.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Freenome has adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law.&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll bring:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD (or equivalent industry experience) in molecular biology, biochemistry, chemistry, or a related field, with specific domain knowledge in cancer biology, immunology, and/or functional proteomics.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;3+ years post-PhD (for Senior-level) experience in proteomics assay development or biomarker discovery, with working knowledge of complex biological samples (e.g., plasma and tissue) and associated sample treatment methods (e.g., depletion, enrichment, and fractionation).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proven track record of establishing or evaluating proteomics techniques for biomarker discovery and protein quantitation, including mass spectrometry and immunoaffinity approaches.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to perform data analysis to enable experimental iteration independent of external support.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Clear communication skills and ability to work with team members in the same and adjacent disciplines.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to manage research projects with contract research organizations, and to mentor and train research associates and junior scientists.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Valuable supplementary skills include:&lt;/span&gt;&lt;/li&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Hands-on experience with multiplexed and/or high-throughput analytical platforms, such as peptide arrays, protein arrays, mass spectrometry, Luminex, Olink, and MSD.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with experimental techniques for expressing, purifying, modifying, and characterizing protein products.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with isolation, characterization, and analysis of extracellular vesicles&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience identifying and characterizing phospho- or glycoproteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Fluency in a common scientific programming language (e.g., Python, R).&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;About Freenome&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent cancer.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We have pioneered the most comprehensive multiomics platform for early cancer detection through a routine blood draw.&amp;nbsp; By combining deep expertise in molecular biology with advanced computational biology and machine learning techniques to recognize disease-associated patterns among billions of circulating, cell-free biomarkers, we are developing simple and accurate blood tests for early cancer detection and integrating the actionable insights into health systems to operationalize a machine learning feedback loop between care and science.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Our recent $270 Million Series C brings our financing to over $500 million from investors, including;&amp;nbsp; Bain Capital, Perceptive Advisors, RA Capital, Polaris Partners, Andreessen Horowitz, funds and accounts advised by T. Rowe Price Associates, Inc., GV (formerly Google Ventures), Roche Venture Fund, Kaiser Permanente Ventures, American Cancer Society’s BrightEdge Ventures, Data Collective Venture Capital, Novartis and Verily Life Sciences.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Science&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is building technology to advance the understanding of cancer through multiple analytes derived from blood. These signals include cell-free DNA, methylation of cell-free DNA, cell-free RNA, circulating proteins, and immune profiling derived from thousands of prospective samples. By developing novel statistical learning methods and applying them to integrate various -omics datasets, Freenome is a leader in modeling specific biological mechanisms to capture disease-dependent signatures, including gene expression, immune response, tumor burden, the tissue of origin, and 3D chromatin structure.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;By building comprehensive discovery datasets and modeling critical biological systems, Freenome is learning what biological changes are present within the blood between a variety of different disease states, including cancer, autoimmune disorders, infections, drug response, and aging. The synthesis of Freenome’s datasets, cross-functional technical expertise, and audacious mission to discover biological truth, we seek to improve the lives of millions through early detection and early treatment of disease.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Culture&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenomers are technical, creative, visionary, grounded, empathetic, and passionate. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. Freenomers are some of the most talented experts in their fields, joining together to advance healthcare, one breakthrough at a time.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We value empathy, integrity, and trust in one another, and we respect the diverse perspectives of our colleagues and those we serve.&amp;nbsp; We assume positive intent and give each other the benefit of the doubt with the firm belief that we are a team working toward the same objectives.&amp;nbsp; We believe in empowering and supporting each other in a collaborative and dynamic environment.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;What does a successful person look like at Freenome?&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Those who thrive at Freenome prioritize, manage, and execute their own goals with ownership and alignment with those of the company. They embrace our values of empathy, integrity, striving for greatness, servant leadership, trust, and holding themselves and their team accountable to these values. They crave collaboration with brilliant minds from disparate fields of study and believe that hiring and mentorship are fundamental to our success. Above all, they welcome and provide constructive feedback and criticism, trusting in others’ good intentions, and being secure in knowing that embracing mistakes is the best way to learn and grow. For those who pursue challenges, understudied problems, and want the opportunity to see their work impact the lives of millions of people affected by cancer every year, there’s no better place to be than Freenome.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status, or any other basis covered by appropriate law.&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior/Research Scientist, Proteomics Biomarker

&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;As a Staff Computational Biologist focused on Cancer Biology at Freenome, you will be a key scientific leader in the development of early, noninvasive tests for cancer detection. As a senior member of the team, you will use a strong foundation of the biological mechanisms of cancer to motivate hypotheses, develop, and make improvements to computational algorithms detecting molecular signatures of cancer. You will work closely with and lead the work of machine learning scientists, molecular biologists, and other computational biologists on a collaborative team to drive the iteration of computational models and assays while ultimately developing products which can be used in the clinic. &lt;/span&gt;&lt;/p&gt;
&lt;p&gt;How you’ll contribute:&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Lead the analysis and interpretation of molecular and clinical data in the context of early cancer detection, serving as a key thought-leader on the computational science team.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Motivate research hypotheses and areas for potential model improvement, and subsequently plan, scope, and execute associated research with a talented team of computational biologists.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Leverage, develop, and apply machine-learning and statistical tools for models development and interpretation .&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Remain at the forefront of research developments in cancer biology, including but not limited to early cancer detection and molecular signatures across various types and stages of cancer.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Use foundational knowledge in cancer biology to analyze and interpret data from best in class molecular assays such as whole genome sequencing, whole genome bisulfite sequencing, targeted sequencing, RNA sequencing, and protein quantitation.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Work closely with molecular biologists to collaboratively iterate on experiments in the wet lab. &lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;What you’ll bring:&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD or equivalent experience in a relevant field such as biology, cancer biology, computational biology, computer science, and other quantitative fields.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;5+ years post-PhD experience applying computational techniques for biological discovery and product development, ideally in industry.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience in developing, applying, and evaluating statistical and/or machine learning algorithms.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Extensive knowledge of cancer biology and molecular biology, with experience leveraging this knowledge for problems in cancer computational biology and diagnostics.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with computational and statistical programming, including experience with Python statistical and machine-learning packages. Equivalents in other languages like R are also suitable.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Strong quantitative reasoning and statistical analysis skills, with a demonstrated ability to apply them effectively to relevant scientific problems.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience in the analysis of high-throughput, quantitative technologies in genomics, epigenomics, proteomics, or transcriptomics (e.g. Hi-C, ATAC-seq, RNA-seq, MS).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Expertise with biological and genomic data, tools, and associated public databases (e.g. ENCODE, TCGA, Blueprint, Cosmic).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Excellent oral and written communication skills to communicate to both scientific and broader audiences.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience mentoring or managing junior scientists, with an ability to work on a cross-functional team (with both computational and experimental scientists).&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Freenome has adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;About Freenome&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent cancer.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We have pioneered the most comprehensive multiomics platform for early cancer detection through a routine blood draw.&amp;nbsp; By combining deep expertise in molecular biology with advanced computational biology and machine learning techniques to recognize disease-associated patterns among billions of circulating, cell-free biomarkers, we are developing simple and accurate blood tests for early cancer detection and integrating the actionable insights into health systems to operationalize a machine learning feedback loop between care and science.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Our recent $270 Million Series C brings our financing to over $500 million from investors, including;&amp;nbsp; Bain Capital, Perceptive Advisors, RA Capital, Polaris Partners, Andreessen Horowitz, funds and accounts advised by T. Rowe Price Associates, Inc., GV (formerly Google Ventures), Roche Venture Fund, Kaiser Permanente Ventures, American Cancer Society’s BrightEdge Ventures, Data Collective Venture Capital, Novartis and Verily Life Sciences.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Science&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is building technology to advance the understanding of cancer through multiple analytes derived from blood. These signals include cell-free DNA, methylation of cell-free DNA, cell-free RNA, circulating proteins, and immune profiling derived from thousands of prospective samples. By developing novel statistical learning methods and applying them to integrate various -omics datasets, Freenome is a leader in modeling specific biological mechanisms to capture disease-dependent signatures including gene expression, immune response, tumor burden, the tissue of origin, and 3D chromatin structure.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;By building comprehensive discovery datasets and modeling critical biological systems, Freenome is learning what biological changes are present within the blood between a variety of different disease states including cancer, autoimmune disorders, infections, drug response, and aging. The synthesis of Freenome’s datasets, cross-functional technical expertise, and intrepid mission to discover biological truth, we seek to improve the lives of millions through early detection and early treatment of disease.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Culture&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenomers are technical, creative, visionary, grounded, empathetic, and passionate. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. Freenomers are some of the most talented experts in their fields, joining together to advance healthcare, one breakthrough at a time.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We value empathy, integrity, and trust in one another and we respect the diverse perspectives of our colleagues and of those we serve.&amp;nbsp; We assume positive intent and give each other the benefit of the doubt with the firm belief that we are a team working toward the same objectives.&amp;nbsp; We believe in empowering and supporting each other in a collaborative and dynamic environment.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;What does a successful person look like at Freenome?&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Those who thrive at Freenome prioritize, manage, and execute their own goals with ownership and in alignment with those of the company. They embrace our values of empathy, integrity, striving for greatness, servant leadership, and trust, and hold themselves and their team accountable to these values. They crave collaboration with brilliant minds from disparate fields of study and believe that hiring and mentorship are fundamental to our success. Above all, they welcome and provide constructive feedback and criticism, trusting in the good intentions of others, and being secure in the knowledge that embracing mistakes is the best way to learn and grow. For those who pursue challenges, understudied problems, and want the opportunity to see their work impact the lives of millions of people affected by cancer every year, there’s no better place to be than Freenome.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status, or any other basis covered by appropriate law.&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Staff Computational Biologist - Cancer Biology

&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;SENIOR/RESEARCH SCIENTIST, PROTEOMICS BIOANALYTICAL&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;About the Role&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;At Freenome, our goal is to improve patient outcomes by pioneering the next-generation of blood tests for early and accurate disease detection using our combined multi-omics and machine learning platform. As a (Senior) Research Scientist in Protein Analytics, you will contribute to the program’s technical base by creating and optimizing workflows using cutting edge analytical&amp;nbsp; technology and instrumentation to characterize proteins and custom protein-based assay reagents. Technologies of interest include mass spectrometry, multiplexed immunoassays, flow cytometry, ELISA, and Bio-Layer Interferometry, among other high-end analytics for protein, vesicle, and nanoparticle characterization. In this role, you will lead projects to integrate existing cutting-edge instrumentation into Freenome’s laboratory and evaluate emergent technologies that have the potential to improve and expand upon our current capabilities. You will also work closely with computational biologists and product development scientists to provide biological and technical insights, and to provide new data sources to enhance ongoing research and development projects.&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;How you’ll contribute:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Provide expert technical leadership on projects involving assessment and deployment of new analytical technologies, scoping project objectives and milestones.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Assess, develop, and employ novel assays, analytical technologies, and instrumentation to characterize or quantify proteins in multiple contexts, including target biomarkers in biofluids and custom recombinant reagents.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Identify and evaluate opportunities to integrate new proteomics technologies into Freenome’s multiomics platform and products.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Refine existing proteomic analytical assays by characterizing assay performance and implementing workflow and protocol improvements (including biofluid sample collection, protein extraction and depletion, and quantitation on discovery or targeted platforms).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Work closely with research and development biologists to provide analytical and biochemical expertise as well as experimental solutions in the proteomic analysis space.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with computational biologists and software engineers to build analysis pipelines that appropriately integrate new molecular technologies.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Freenome has adopted a COVID-19 vaccination policy to safeguard the health and well-being of our employees. As a condition of employment, our employees working on-site are required to be fully vaccinated for COVID-19, unless a reasonable accommodation is approved or as otherwise required by law.&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll bring:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD (or equivalent industry experience) in biochemistry, analytical chemistry, or a related field, with specific domain knowledge in cancer biology, immunology, and/or protein analytics.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;3+ years post-PhD experience for Senior-level (or 0-3 years for Scientist) in proteomics assay development and/or protein analytics, with working knowledge of analytical instrumentation for characterizing proteins and peptides (e.g., liquid chromatography, mass spectrometry, flow cytometry).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proven track record of establishing or evaluating new assays for protein identification, characterization, and quantitation, including mass spectrometry and immunoaffinity approaches at the global and targeted scales.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to perform basic data analysis to enable experimental iteration independent of external support.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Clear communications skills and ability to work with team members in the same and adjacent disciplines.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to manage research projects with contract research organizations, and to mentor and train research associates.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Valuable supplementary skills include:&lt;/span&gt;&lt;/li&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Hands-on experience with multiplexed and/or high-throughput analytical platforms, such as peptide arrays, protein arrays, mass spectrometry, Luminex, Olink, and MSD.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience with experimental techniques for analyzing critical attributes of nanoparticles, extracellular vesicles, and/or cells, such as dynamic light scattering, advanced microscopy, and binding properties.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Fluency in a common scientific programming language (e.g., Python or R).&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;About Freenome&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent cancer.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We have pioneered the most comprehensive multiomics platform for early cancer detection through a routine blood draw.&amp;nbsp; By combining deep expertise in molecular biology with advanced computational biology and machine learning techniques to recognize disease-associated patterns among billions of circulating, cell-free biomarkers, we are developing simple and accurate blood tests for early cancer detection and integrating the actionable insights into health systems to operationalize a machine learning feedback loop between care and science.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Our recent $270 Million Series C brings our financing to over $500 million from investors, including;&amp;nbsp; Bain Capital, Perceptive Advisors, RA Capital, Polaris Partners, Andreessen Horowitz, funds and accounts advised by T. Rowe Price Associates, Inc., GV (formerly Google Ventures), Roche Venture Fund, Kaiser Permanente Ventures, American Cancer Society’s BrightEdge Ventures, Data Collective Venture Capital, Novartis and Verily Life Sciences.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Science&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is building technology to advance the understanding of cancer through multiple analytes derived from blood. These signals include cell-free DNA, methylation of cell-free DNA, cell-free RNA, circulating proteins, and immune profiling derived from thousands of prospective samples. By developing novel statistical learning methods and applying them to integrate various -omics datasets, Freenome is a leader in modeling specific biological mechanisms to capture disease-dependent signatures, including gene expression, immune response, tumor burden, the tissue of origin, and 3D chromatin structure.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;By building comprehensive discovery datasets and modeling critical biological systems, Freenome is learning what biological changes are present within the blood between a variety of different disease states, including cancer, autoimmune disorders, infections, drug response, and aging. The synthesis of Freenome’s datasets, cross-functional technical expertise, and audacious mission to discover biological truth, we seek to improve the lives of millions through early detection and early treatment of disease.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;Our Culture&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenomers are technical, creative, visionary, grounded, empathetic, and passionate. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. Freenomers are some of the most talented experts in their fields, joining together to advance healthcare, one breakthrough at a time.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We value empathy, integrity, and trust in one another, and we respect the diverse perspectives of our colleagues and those we serve.&amp;nbsp; We assume positive intent and give each other the benefit of the doubt with the firm belief that we are a team working toward the same objectives.&amp;nbsp; We believe in empowering and supporting each other in a collaborative and dynamic environment.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 500;&quot;&gt;What does a successful person look like at Freenome?&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Those who thrive at Freenome prioritize, manage, and execute their own goals with ownership and alignment with those of the company. They embrace our values of empathy, integrity, striving for greatness, servant leadership, trust, and holding themselves and their team accountable to these values. They crave collaboration with brilliant minds from disparate fields of study and believe that hiring and mentorship are fundamental to our success. Above all, they welcome and provide constructive feedback and criticism, trusting in others’ good intentions, and being secure in knowing that embracing mistakes is the best way to learn and grow. For those who pursue challenges, understudied problems, and want the opportunity to see their work impact the lives of millions of people affected by cancer every year, there’s no better place to be than Freenome.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status, or any other basis covered by appropriate law.&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior/Research Scientist, Proteomics Bioanalytical

&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an expert in biological systems modeling to join our multidisciplinary team of translational data scientists to expand our ability to quantitatively predict the behavior of biochemical networks at the single-cell, tissue, and patient level. This brand-new role has the potential to accelerate both the basic science and drug development pipelines at Calico, and to have a practical impact on the development of therapies for age-related disease.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Calico we’re generating terabytes of data to support our translational efforts, from multi-omic single cell measurements to image-based data sets. This role will seek to build complex computational models (such as QSP models, multi-scale models, and others) that help unify the diverse data streams and generate testable new insights. Crucially, this postdoc will be expected to partner with our discovery and translational teams to iteratively build these models, extracting key insights that will further our understanding of aging. Our ideal candidate is someone who sees themselves as team-oriented and thrives when given space to innovate. In addition to ample opportunities for ownership and publication, this role will have the support of a multidisciplinary team that includes engineers, physicists, biochemists, biologists, machine learning experts, software engineers, and data analysts.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and iterate on complex mathematical models of biological/physiological systems&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Work with pre-clinical or human physiology/disease progression datasets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Build and apply Quantitative Systems Pharmacology (QSP) models to support our basic science &amp;amp; drug development pipelines&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Communicate research results through conference presentations, scientific publications, or project reports&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Collaborate with scientists on experimental designs to best position downstream analyses&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Stay up-to-date on cutting-edge technology and developing new analysis methods based on demand&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD in computer science, mathematics, biology, or related discipline&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Proficiency with systems modeling approaches such as ordinary/partial differential equations, stochastic, agent-based, and/or other advanced mechanistic modeling approaches&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Familiarity or experience with QSP or other translationally-relevant mathematical modeling techniques a plus&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with relevant software or programming languages (e.g., Python, Simbiology, MATLAB, R, or C)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent understanding of statistical aspects of mathematical modeling, including for example numerical methods, parameter optimization/estimation, uncertainty quantification and sensitivity analysis.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Values scientific discovery and has an unquenchable curiosity&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Possessing basic biology background sufficient to guide and inform analysis approaches&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knows when to apply off-the-shelf solutions versus develop cutting-edge methods&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Track record of outstanding communication and collaboration in a cross-functional environment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Calico Postdoctoral Fellowship Program:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico’s Postdoctoral Fellowship Program pairs recent PhD graduates with internal expertise to conduct fundamental and innovative research and investigate meaningful scientific questions aligned with our mission to understand the biology of human aging and develop interventions for age-related diseases. Postdoctoral Fellows at Calico receive mentorship and support to develop independent research programs to enable the next stage of their careers. In addition to direct mentorship from their host laboratories, Postdoctoral Fellows benefit from collaboration with diverse scientists across Calico’s Research and Technology groups and are encouraged and supported to communicate their findings through high-impact, peer-reviewed scientific journals and conferences.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Program Features:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Fully integrated into Calico’s labs and community, Postdoctoral Fellows pursue new research directions with devoted resources for innovative and potentially high-risk research and bring new personalities, ideas, technology and perspectives to Calico.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico’s program is a fixed-term educational assignment for individuals who have recently completed their PhD degrees, have had a meaningful first author paper accepted for publication, and have made important contributions to science in their area.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;While postdocs will focus on their own project(s), mutually agreed to in principle and prior to making the decision to join the mentor’s lab, the expectation is that they all contribute to furthering our understanding of aging and age-related diseases.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Postdoc assignments are up to four years in length. It is expected that the postdoc will receive regular feedback and guidance from their mentor in addition to participating in a more formal annual review process to discuss project progress, individual performance, and career coaching.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Our postdoc projects are expected to yield work that can be submitted for publication in a timely fashion upon completion and are intended to train people to become independent investigators in an academic or industry setting upon successful completion of the assignment.&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico postdocs join a community of other Postdoctoral Fellows who regularly engage with members of Calico’s scientific community, including senior leadership, through a variety of professional and career development opportunities.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;

Postdoctoral Fellow, Biological Systems Modeling

&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers.&amp;nbsp; We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science.&amp;nbsp; We are a learning organization, dependent on deep collaborative relationships between our colleagues, partners, and founders.&amp;nbsp; Our culture is based on Science, Respect, Courage and Collaboration, and it reflects who we are and the environment we are creating.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The Research Associate II will work collaboratively with supervising Scientists and the broader research team to develop and perform the standard assays for their specific project. Function semi-independently to troubleshoot problems that arise within these assays and think creatively to improve upon existing protocols. Work closely with colleagues in other areas of research and can involve more complex and specialized areas of a specific project. Responsible for keeping abreast of current publications relative to methods, techniques, and developments within the area of research.&amp;nbsp; Responsible for carrying out specific experiments, usually confined to a single greater Research and Development aim in one technical area&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;KEY ROLE AND RESPONSIBILITIES&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Can execute experiments independently, requires assistance in the design and analysis of experiments&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Collaborate internally with Scientists and other research associates to interrogate our novel therapies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Setup and maintenance of a highly functioning lab; can be responsible for more in depth maintenance and function of specialized equipment&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analysis and presentation of experimental data to project teams&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Generation and maintenance of electronic lab notebook reports&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;PREFERRED EDUCATION:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;BSc in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 5 years’ experience within the area of focus&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;MSc in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 3 years’ experience within the area of focus&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;PREFERRED EXPERIENCE:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with basic molecular biology protocols (i.e. PCR, Western, RT-PCR, basic cloning)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience using and analyzing common immunology and oncology assays related to the specific project&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Proficient in sterile tissue culture technique and experience working with human cells&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in data production and reporting for IND-enabling studies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience recording data in electronic notebook&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Additional specific experience related to the area of focus may be required&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Knowledge, Skills and Abilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Understands the theoretical basis and experimental objectives and how they fit into the overall project goals&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledgeable and proficient in a range of technical skills within their area of research&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Highly proficient in using Microsoft Office (Word, Excel, PowerPoint) and data analysis software packages (Prism, Flow Jo, Spotfire, Geneious, etc)&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Effectively communicate and discuss results with other scientists on the team&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ability to work in a matrixed environment&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;General comfort in learning to work with new software and automated lab equipment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Lyell is proud to be an equal opportunity employer and does not discriminate based on race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status, or any other characteristics protected under applicable federal, state, and local laws.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.&amp;nbsp; This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).&amp;nbsp; Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.&amp;nbsp; The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.&amp;nbsp; The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at careers@lyell.com&lt;/span&gt;&lt;/p&gt;

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