&lt;h4&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/h4&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking an expert Data Scientist to join our multidisciplinary team of mass spectrometrists, biologists and computer scientists to become an integral part of our solution for metabolomics and lipidomics experiments.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Calico we’re producing substantial mass spectrometry data related to metabolomics and lipidomics, including LC-QQQ-MS, LC-HRMS, and direct-infusion-MS data modalities to support experiments ranging from custom one-offs to large cohort studies and spanning models that include yeast, tissue culture, and &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vivo&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; systems. This role will work collaboratively with members of the Metabolomics group, the Computing team, and the broader research organization to design experiments, get the most out of the data generated to improve biological understanding, and contribute to changes in the analytical methods that will lead to improved data generation. The ideal candidate is someone who sees themselves as adept at mass spectrometry data analysis and thrives when given space to innovate. This role will have the support of a multidisciplinary team that includes engineers, physicists, biochemists, biologists, machine learning experts, software engineers, and data analysts.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Work with scientists throughout R&amp;amp;D to design experiments and contribute to the analysis of the resulting data&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop new methods for the analysis and visualization of metabolomics and lipidomics data to enhance biological insights, and implement them for use by others (preferably in R) as needed&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Assess and implement external software solutions as needed to complement in-house software&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Apply cutting-edge statistical methods to derive robust &amp;amp; reproducible biological insights&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Empower and coach fellow scientists on their own experimental analysis needs&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ph.D. with 1-2 years or M.S. with 5+ years B.S. with 7+ years relevant data science and software development experience&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with mass spectrometry data&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Biology and metabolism background sufficient to guide and inform analysis approaches&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Successful track record of performing data analysis on biological data sets to extract additional biological understanding&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience applying statistical and machine learning methods&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extremely collaborative, with a mentality of trying to add value to many projects across Calico&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite three days a week&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice-to-haves:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Familiarity with externally available mass spectrometry and metabolism-related software tools&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in joining metabolomics data with other data modalities, including proteomics and genomics&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Knowledge of &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in silico&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; representations of metabolism, such as genome-scale metabolic models&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Comfort with additional programming languages (e.g., Python, SQL, Julia)&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The estimated base salary range for this role is $134,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.&amp;nbsp; As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2 id=&quot;ojxVC&quot; class=&quot;wLzlc&quot;&gt;&lt;/h2&gt;

Data Scientist/Senior Data Scientist, Metabolomics

&lt;h4&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/h4&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico is seeking a Senior Data Scientist to join our efforts in advancing novel therapies through the drug development pipeline to clinical development. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In this role you will work closely with translational scientists, external partners and collaborators to advance Calico’s &lt;/span&gt;&lt;a href=&quot;https://www.calicolabs.com/press/calico-and-abbvie-share-update-on-early-stage-clinical-programs&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;translational programs&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; targeting modulators of age-related diseases spanning a broad range of disease areas, including oncology and neurodegeneration. Our programs target fundamental biological processes, informed by aging biology, whose dysregulation may contribute to multiple diseases.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;As a member of the Calico’s Computing team, you will work closely with a cross-functional group of computational biologists, machine learning engineers, data scientists, translational project leads, scientists, and biostatisticians to advance Calico’s pipeline. This role offers a unique opportunity to innovate at the leading edge of data science.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analyze high-dimensional phenotypic data (genomics, transcriptomics, metabolomics, proteomics, and imaging, across multiple experimental conditions) to answer key questions for our development programs as they advance towards the clinic. This will involve translating insights across datasets including cell culture models, animal models, early stage human research, and public datasets.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and quantify novel biomarkers that capture the state of a disease, target engagement, or patient selection.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Interface with translational scientists in both the Research and Drug Development organizations; recommend experimental strategies and appropriate designs to gather evidence; interpret experimental findings both as an individual contributor and subject-matter expert in data and disease.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Work with other data scientists and engineers on the Computing team to design and build systems and visualizations to enable data exploration by drug developers and researchers across Calico.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Communicate clearly and effectively in verbal, visual, and written form to stakeholders with varying levels of technical knowledge.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Ph.D./MS in a quantitative field such as Computational Biology, Genomics, Computer Science, Bioinformatics, Statistics, Biological Sciences, or equivalent preparation and 4+ years of work experience.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Demonstrated experience analyzing biological data and expertise in a disease area of interest to Calico (broadly defined as age-related disease, examples include oncology and neurodegeneration).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience with testing statistical hypotheses using high-dimensional genomic or other omics data (e.g., bulk RNAseq, single-cell RNAseq, ribosome profiling, ATACseq/ChipSeq, metabolomics, proteomics, imaging).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Fluent in R and/or Python with experience using industrial best practice (version control, unit testing, and package management).&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in applying statistical methods, such as: generalized linear models, hazard models, maximum likelihood estimation, and false discovery rate control.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Track record of effective cross-functional collaboration.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite three days a week.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Nice to haves:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;2+ years experience working on drug development in an industry setting.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The estimated base salary range for this role is $169,000 - $172,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.&amp;nbsp; As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2 id=&quot;ojxVC&quot; class=&quot;wLzlc&quot;&gt;&lt;/h2&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Senior Data Scientist, Translational Bioinformatics

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico seeks a data scientist with image analysis expertise.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role exists within a small, cross-functional team, whose research focuses on the biology of the extracellular matrix (ECM) and connective tissue.&amp;nbsp; The team combines in vivo, genetic, cell biology and data science techniques to study the decay of connective tissue and its impacts on broader biology.&amp;nbsp; In this role, you will be accountable for the development and application of image analytics relevant to the team’s study of ECM form and function.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;You will work with image data spanning multiple bioimaging paradigms, including: high-resolution microscopy; video footage of &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vivo&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; models; histology; and human clinical imaging (MRI, CT, DEXA, etc.).&amp;nbsp; You will develop analytical techniques using both classical and machine-learning (ML) methods, and you will apply those methods to real data collected within Calico as well as from large, externally-generated human cohorts (e.g. the UK BioBank).&amp;nbsp; The outputs of your analyses will serve as phenotypic endpoints for experimental and epidemiological studies.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In this role, you will be responsible for implementing innovative image analysis techniques to solve problems that are central to the group’s research objectives.&amp;nbsp; You will also be responsible for applying your analytical methods to large-scale data sets.&amp;nbsp; To accomplish both tasks, you will have the opportunity to collaborate with wider communities of ML and software engineers working at Calico.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Additional job activities will include the oral presentation of methods/results; write-up of methods/results for external publication; and the preparation of code for open-source distribution.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;An MS or PhD in either Computer Science or Biology, or related fields;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;2+ years experience applying computer science techniques to the analysis of biological or medical image data (may overlap with degree work);&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;A history of publication/code release that reflects the successful application of computational image analysis to scientific questions;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Direct experience training, evaluating &amp;amp; applying an ML model for image analysis;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Programming fluency in python;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Nice to have: experience with cloud computing on the Google Cloud Platform;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Must be willing to work onsite at least three days per week&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The estimated base salary range for this role is $99,000 - $126,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.&lt;/span&gt;&lt;/p&gt;

Data Scientist, Image Analysis

&lt;div&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;Key to insitro’s approach to rethinking drug development is leveraging disease models, genetics, and clinical datasets to link in vitro and cellular phenotypes with patient outcomes.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;Multimodal clinical datasets are an essential component of modeling patient heterogeneity, disease progression, and phenotypic diversity. Our goal is to develop sophisticated models from patient clinical records, common lab biomarkers, and, when available, high-content multi-omic and imaging data to identify coherent patient segments to reveal novel genetic signals and opportunities for targeted therapies.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;As a clinical machine learning scientist, you will develop, productionize, and deploy cutting-edge ML approaches to analyze and integrate large-scale multi-modal phenotypic datasets, including electronic health records, physiological monitoring, longitudinal clinical data, biomarkers, and multi-omic modalities. You will work with clinical data from large human cohorts such as randomized clinical trials, electronic health records, national biobanks, and other sources. You will contribute to developing models to understand patient state and predict outcomes and clinical endpoints. You will collaborate with a cross-functional team of machine learning scientists, statistical geneticists, life scientists, and clinicians to identify therapeutic targets and develop drugs that have high efficacy and low toxicity. You will work in collaboration with the software engineering team to ensure these pipelines are robust, reusable platform components that can be deployed on large-scale datasets in a portable way.&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;You will be joining a vibrant biotech startup that has long-term stability due to significant funding, yet is in a high growth phase. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients! This role is preferably based in San Francisco Bay Area or Boston, but we are open to discussing other locations in the United States and the UK.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in biomedical informatics, machine learning, computer science, or a related discipline, or equivalent practical experience (e.g., a Masters degree plus 2 years in relevant industry experience);&lt;/li&gt;
&lt;li&gt;Demonstrated ability to use cutting edge statistical and machine learning methods for analyzing clinical data;&lt;/li&gt;
&lt;li&gt;Extensive hands-on experience working with at least one of the following areas: real-word data such as electronic health records (EHR/EMR), insurance claims, or clinical trial data; disease progression modeling;&lt;/li&gt;
&lt;li&gt;Demonstrated ability to rigorously identify and deal with confounders and complexities in human clinical data;&lt;/li&gt;
&lt;li&gt;Proficiency in Python or R;&lt;/li&gt;
&lt;li&gt;Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions;&lt;/li&gt;
&lt;li&gt;Passion for making a difference in the world.&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Nice to Have&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Experience with association testing, statistical or causal inference, and uncertainty evaluation;&lt;/li&gt;
&lt;li&gt;Experience with natural language processing (NLP) on real-world data, especially deriving features from unstructured clinical notes, phenotype ontologies, or other text containing medical terminologies;&lt;/li&gt;
&lt;li&gt;Experience with longitudinal data, time series analyses (e.g. data from wearable devices);&lt;/li&gt;
&lt;li&gt;Experience with genomic data (e.g. RNA-seq, proteomics, metabolomics, methylation, etc.) or biomedical/biophysical imaging modalities;&lt;/li&gt;
&lt;li&gt;Experience using modern deep learning frameworks (PyTorch, Jax, XGBoost, etc);&lt;/li&gt;
&lt;li&gt;Familiarity with cloud computing services (e.g., AWS or GCP) and workflow management tools or batch scheduling systems (e.g. SLURM);&lt;/li&gt;
&lt;li&gt;Proficiency in Linux environment (including shell/Bash scripting), experience with database languages (e.g., SQL) and experience with version control practices and tools (e.g., Git)&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Compensation &amp;amp; Benefits at insitro&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Our target starting salary for successful US-based applicants for this role is $160,000 - $215,000. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;the level at which they are actually hired,&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;market demand, business needs, and internal parity. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We may also adjust this range in the future based on market data.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In addition, insitro also provides our employees:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;401(k) plan with employer matching for contributions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Open, flexible vacation policy&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Paid parental leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Quarterly budget for books and online courses for self-development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support to occasionally attend professional conferences that are meaningful to your career growth and development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;New hire stipend for home office setup&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Monthly cell phone &amp;amp; internet stipend&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite baristas and cafe with daily lunch and breakfast&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite fitness center&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Commuter benefits&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;div class=&quot;section page-centered&quot;&gt;
&lt;p&gt;&lt;strong&gt;About insitro&lt;/strong&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;div class=&quot;section page-centered&quot;&gt;
&lt;div&gt;insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&amp;amp;D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at&amp;nbsp;&lt;a class=&quot;postings-link&quot; href=&quot;http://www.insitro.com/&quot;&gt;www.insitro.com&lt;/a&gt;.&lt;/div&gt;
&lt;/div&gt;&lt;/div&gt;

Clinical Machine Learning Scientist III

&lt;div class=&quot;p-rich_text_section&quot;&gt;At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.&lt;/div&gt;
&lt;div class=&quot;p-rich_text_section&quot;&gt;
&lt;p&gt;&lt;strong&gt;POSITION SUMMARY:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The incumbent designs, develops and supports the implementation of clinical biomarker assays to interrogate the pharmacokinetics (PK), pharmacodynamics (PD) and mechanism of action (MOA) of cellular therapies.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;KEY ROLE AND RESPONSIBILITIES:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Independently design, validate and support implementation of clinical flow cytometry, single cell RNA sequencing (scRNAseq) and &lt;em&gt;ex vivo&lt;/em&gt; cell-based assays for use in evaluating clinical biomarker samples&lt;/li&gt;
&lt;li&gt;Critically analyze experimental results and interpret complex datasets that inform the testing of clinical research hypothesis&lt;/li&gt;
&lt;li&gt;Develop, trouble-shoot and optimize biomarker sample collection, processing and analysis solutions for interrogating PK, PD and MOA by flow cytometry, scRNAseq and cell-based assays in the clinical trial setting&lt;/li&gt;
&lt;li&gt;Collaborate with expert internal and CRO-based colleagues to support the implementation of next-generation sequencing (NGS), epigenetic (ATACseq) and tissue-based (IHC, ISH) biomarker analysis platforms&lt;/li&gt;
&lt;li&gt;Serve as subject matter expert and present assay development, clinical biomarker data and interpretations to project teams, other functional groups (e.g., non-clinical research, process development) and/or to external stakeholders.&lt;/li&gt;
&lt;li&gt;Author assay protocols, SOPs, clinical lab manual sections and related materials for documentation, implementation and communication of clinical biomarker-related results and protocols&lt;/li&gt;
&lt;li&gt;Evaluate new technologies, methods and platforms to enhance the quantity, quality and impact of clinical biomarker data&lt;/li&gt;
&lt;li&gt;Maintain high level of technical and scientific expertise leveraging scientific literature, conferences, internal meetings and training opportunities&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;PREFERRED EDUCATION: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;BSc in immunology, oncology or related field with a minimum of 13 years’ experience within the area of focus; or&lt;/li&gt;
&lt;li&gt;MSc in immunology, oncology or related field with a minimum of 11 years’ experience within the area of focus; or&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;PhD in immunology, oncology or related field with a minimum of 6 years’ experience within the area of focus&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;PREFERRED EXPERIENCE: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Breadth and depth of experience in studying immune cell biology using &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;ex vivo&lt;/em&gt; research technologies with an emphasis on high dimensional flow cytometry and scRNAseq&lt;/li&gt;
&lt;li&gt;Strong expertise in techniques, such as primary cell tissue culture, to interrogate immune cell activity in physiologically relevant &lt;em&gt;in vitro&lt;/em&gt; / &lt;em&gt;ex vivo&lt;/em&gt; model systems&lt;/li&gt;
&lt;li&gt;Experience either directly validating or working closely with a CRO to validate flow cytometry assays at the GCLP and/or CAP/CLIA level&lt;/li&gt;
&lt;li&gt;Application of GLP/GCLP regulatory guidance and industry white papers relevant to clinical biomarker assay validation and implementation&lt;/li&gt;
&lt;li&gt;Expertise in the use of relevant data analysis software (FloJo, CellEngine, Prism, Excel, Spotfire etc.)&lt;/li&gt;
&lt;li&gt;Experience in the development of clinical immunogenicity assays&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;KNOWLEDGE, SKILLS AND ABILITIES:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Demonstrated ability to build, lead and motivate teams across multiple functions&lt;/li&gt;
&lt;li&gt;Collaborative leadership style&lt;/li&gt;
&lt;li&gt;Proven expertise in experimental design and application of flow cytometry and immune cell-based assay platforms to test hypotheses in the areas of immune-oncology and/or T cell biology.&lt;/li&gt;
&lt;li&gt;Direct experience adapting discovery stage assays used in non-clinical biomarker discovery for use in samples from early-stage clinical trials.&lt;/li&gt;
&lt;li&gt;Expertise in developing and implementing robust, validated clinical flow cytometry and cell-based assays in the biotherapeutic and/or cell therapy development space.&lt;/li&gt;
&lt;li&gt;Experience working with bioinformatics colleagues to analyze and interpret NGS data&lt;/li&gt;
&lt;li&gt;Ability to work independently as well as on interdisciplinary teams to achieve organizational objectives&lt;/li&gt;
&lt;li&gt;Written and oral communications skills to function efficiently and effectively in a highly collaborative environment with both internal and external stakeholders&lt;/li&gt;
&lt;li&gt;Ability to take initiative, leverage multiple sources of knowledge and expertise to make decisions and meet complex scientific and operational challenges&lt;/li&gt;
&lt;li&gt;Ability to work efficiently, prioritize workflow, meet deadlines, balance competing priorities and adapt to change&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;div class=&quot;p-rich_text_section&quot;&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.&lt;/p&gt;
&lt;p&gt;The salary range for this position is $160,000 to $175,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.&lt;/p&gt;
&lt;p&gt;Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&amp;amp;D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found on our company website, www.lyell.com&lt;/p&gt;
&lt;p&gt;At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.&lt;/p&gt;
&lt;p&gt;Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.&lt;/p&gt;
&lt;p&gt;The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”&lt;/p&gt;
&lt;p&gt;We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.&lt;/p&gt;
&lt;/div&gt;

Senior Scientist, Clinical Biomarkers

&lt;div&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;The heart of insitro’s strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are putting together a team of life scientists with expertise in cellular and biochemical assays. The Associate Scientist II/III, Liver Cell Biologist will be responsible for the development and execution of mid/high throughput biochemical/cellular assays and mechanistic experimentation to advance early drug discovery projects. The candidate will work closely with a team of multidisciplinary scientists to enable key assays/models and studies to advance a diverse portfolio of small molecules targeting neurological and metabolic disorders. We value clear communication, creative-thinking, collaboration, and meticulous scientific exploration. If you are a highly motivated individual and teammate with a strong desire to impact drug discovery across multiple therapeutic areas, we invite you to consider joining our team.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Your primary duties will be to:&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Develop, optimize, and perform cellular assays at to support the Metabolic Diseases therapeutic area&lt;/li&gt;
&lt;li&gt;Culture immortalized, primary (e.g. hepatocytes) and iPSC-derived cells&lt;/li&gt;
&lt;li&gt;Maintain accurate documentation of experiments in electronic lab notebook (ELN) and follow all laboratory training and safety requirements&lt;/li&gt;
&lt;li&gt;Evaluate and implement new enabling technologies and methodologies&lt;/li&gt;
&lt;li&gt;Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver project goals&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;You will be joining a biotech startup with long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a versatile team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;BS/MS in Biochemistry, Cell Biology, Pharmacology or a relevant scientific field, with a minimum of three (3) years of drug discovery experience in a biotech/pharmaceutical setting&lt;/li&gt;
&lt;li&gt;Experience with the development and execution cellular assays, using a wide range of experimental methods and detection technologies including advanced microscopy, ELISA, Alphalisa techniques&lt;/li&gt;
&lt;li&gt;Demonstrated ability to work in cross-functional teams to advance drug discovery, with excellent organization and communication skills&lt;/li&gt;
&lt;li&gt;Hands on experience with various automated liquid handling instrumentation is preferred&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Experience in iPSC differentiation and proliferation assays is preferred&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;
&lt;p&gt;&lt;strong&gt;Compensation &amp;amp; Benefits at insitro&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Our target starting salary for successful US-based applicants for this role is $85,000 - $115,000. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;the level at which they are actually hired,&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;market demand, business needs, and internal parity. &lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We may also adjust this range in the future based on market data.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In addition, insitro also provides our employees:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;401(k) plan with employer matching for contributions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Open, flexible vacation policy&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Paid parental leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Quarterly budget for books and online courses for self-development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support to occasionally attend professional conferences that are meaningful to your career growth and development&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;New hire stipend for home office setup&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Monthly cell phone &amp;amp; internet stipend&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite baristas and cafe with daily lunch and breakfast&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Access to free onsite fitness center&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Commuter benefits&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;/div&gt;
&lt;div&gt;#LI-DH1&lt;/div&gt;
&lt;div&gt;#LI-Onsite&lt;/div&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;div class=&quot;section page-centered&quot;&gt;
&lt;p&gt;&lt;strong&gt;About insitro&lt;/strong&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;div class=&quot;section page-centered&quot;&gt;
&lt;div&gt;insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&amp;amp;D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at&amp;nbsp;&lt;a class=&quot;postings-link&quot; href=&quot;http://www.insitro.com/&quot;&gt;www.insitro.com&lt;/a&gt;.&lt;/div&gt;
&lt;/div&gt;&lt;/div&gt;

Associate Scientist II / III, Liver Cell Biologist

&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Company is seeking to hire a Bioanalytical Scientist in support of small molecule and biomarker bioanalysis efforts within the Bioanalysis group. The successful candidate will work closely with Translational Pharmacology/Bioanalysis (TP&amp;amp;BA) and Biomarker scientists, develop LC-MS/MS methods, and quantitate drug candidates, metabolites, and biomarkers from in vitro and in vivo samples.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Develop and qualify fit-for-purpose LC-MS/MS assays; perform assay maintenance testing of LC-MS/MS methods&lt;/p&gt;
&lt;p&gt;Perform bioanalysis of small molecules and biomarkers in various biological matrices including plasma, urine, CSF, and tissues&lt;/p&gt;
&lt;p&gt;Work with novel biotherapeutic analytes and contribute to development of mass spectrometry methods and analyses for oligonucleotides and proteins.&lt;/p&gt;
&lt;p&gt;Work with TP&amp;amp;BA scientists to develop assays to support in vitro ADME and PK studies&lt;/p&gt;
&lt;p&gt;Interpret data, write scientific reports, review, and QC incoming data from CROs, and communicate bioanalysis results to other scientists and project teams&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;PhD in Analytical Chemistry, Pharmaceutical Chemistry, Drug Metabolism, Pharmacokinetics, or related scientific discipline; or BS/MS with a minimum of 5-7 years of biotech/pharmaceutical or CRO experience in LC-MS/MS bioanalysis&lt;/p&gt;
&lt;p&gt;Hands-on experience with various sample preparation techniques (protein precipitation, liquid-liquid extraction, and solid-phase extraction), chromatographic separation, and operation of triple-quadrupole mass spectrometers is required.&lt;/p&gt;
&lt;p&gt;Working knowledge of quantitative bioanalytical principles, with GLP/GCP regulated assay experience preferable.&lt;/p&gt;
&lt;p&gt;Demonstrated ability to work effectively and collaboratively with other scientists on cross-functional Project Teams.&lt;/p&gt;
&lt;p&gt;Excellent oral presentation and written communication skills.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;Salary Range: $121,000 to $153,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at &lt;a href=&quot;https://www.denalitherapeutics.com/careers&quot; target=&quot;_blank&quot;&gt;https://www.denalitherapeutics.com/careers&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;*This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

LC/MS Bioanalytical Scientist (SM/Biomarker) (6 month contract)

&lt;p&gt;&lt;strong&gt;Why join Freenome?&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To fight the war on cancer, Freenome has raised more than $1.1B from leading investors including a16z, GV (formerly Google Ventures), T. Rowe Price, BainCapital, Perceptive Advisors, RA Capital Management, Roche, Kaiser Permanente Ventures, and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Are you ready for the fight? A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrive in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career. Freenomers are determined, patient-centric, and outcomes-driven. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. We are dedicated to advancing healthcare, one breakthrough at a time.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About this opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Do you like to think deeply about data? Do you intuitively seek to understand the sources of bias, and noise? Do you learn your customer’s application well enough to be&amp;nbsp; sure your work answers the right questions? Do you have expertise developing complex ML and/or deep learning models? Would you like to join a close-knit team of scientists pushing the limits of machine learning methods and changing the paradigm of healthcare from disease treatment to prevention? If that describes you, we want you on our team!&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;The Senior Machine Learning Scientist Healthcare Data will be responsible for developing ML and AI approaches to predictive and prescriptive modeling of disease risks, interventions and other outcomes, from&amp;nbsp; large sets of healthcare data. The successful candidate will need to absorb the relevant clinical background, and to tease apart multiple layers of reporting and selection bias, among other confounders. This position requires a strong grasp of a wide variety of techniques ranging from data mining, study design, and other statistical methods to machine learning. This work is an important component of an integrated early cancer detection strategy that includes Freenome’s blood-based multi-omics molecular assays and will be applied practically to improve clinical care.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;In this role, you will work closely with a small and highly collaborative team of machine learning experts, computational biologists, and data scientists, as well as a broader team of clinical and product experts seeking to change the nature of cancer by catching it early — when curative intervention is most achievable. &lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;This role reports to the Director, Risk Modeling.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;What you’ll do:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Be self-directed and innovative contributor: research the literature, apply and test state-of-the-art ML and AI methods, resolve problems, adapt, compare, iterate and collaborate.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Demonstrate strong command of relevant analytic, ML, AI and biostatistical methods and the ability to find the best approaches for different situations.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Pursue research on methods and applications while prioritizing the transition of insights to production use&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Partner closely with the risk modeling scientists, biostatisticians, clinical, and business specialists.&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Present novel scientific results at conferences and in peer-reviewed scientific journals&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Provide scientific and technical guidance to team members and collaborators while empowering and inspiring them to do their best work&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Take a mindful, transparent, and humane approach to your work.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Must haves:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ph.D. and at least four years of academic or industry experience&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;A record of designing and validating creative solutions to complex quantitative problems as demonstrated by research publications or industry achievements&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience working with large, noisy, and confounded datasets&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to effectively prioritize multiple competing development projects.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proficiency in implementing statistical/ML models in a general-purpose programming language.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Excellent ability to communicate to technical peers and across disciplines, and to work collaboratively on interdisciplinary teams.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;A transparent, self-reflective approach that is comfortable with ambiguity, seeks to improve on or correct flaws in your own work, and is open to others’ suggestions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;A passion for innovation, demonstrated initiative in tackling new areas of research, and an ability to carry great ideas forward to practical and impactful implementation&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Experience with biological or healthcare data is preferred&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Facility reading and interpreting scientific and medical literature is preferred&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Experience with statistical study design is preferred&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Familiarity working in a Linux environment and with cloud computing infrastructure is preferred&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;Experience in scientific parallel computing and/or in distributed computing environments like Kubernetes is preferred.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Benefits and additional information:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;The US target range of our base salary for new hires is $165,750 - $225,000. You will also be eligible to receive pre-IPO equity, cash bonuses, and a full range of medical, financial, and other benefits dependent on the position offered.&amp;nbsp; Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page&amp;nbsp;&lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;@ &lt;/span&gt;&lt;a href=&quot;https://careers.freenome.com/&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;https://careers.freenome.com/&lt;/span&gt;&lt;/a&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt; for additional company information.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local &lt;/span&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;law.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300; color: #ecf0f1;&quot;&gt;#LI-Hybrid&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;

Senior Machine Learning Scientist, Healthcare Data 

&lt;div&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/div&gt;
&lt;div&gt;Global drug development productivity is declining exponentially, with an overall failure to develop effective treatments for many increasingly prevalent complex diseases affecting millions of patients per year. We seek to solve this by combining cutting-edge machine learning techniques with recent advances in life sciences to drastically improve how drugs are discovered and developed.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;This summer we are looking for highly motivated interns looking to work at the intersection of machine learning and life sciences. As a core imaging intern, you will develop ML methods to process and analyze images from multiple microscopy modalities and integrate our in-vitro imaging data to extract insights about disease mechanisms.&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;Insitro has a highly dynamic and collaborative culture in a custom-built open office in South San Francisco. You will work closely with machine learning engineers and scientists, biologists, chemists, microscopy experts, and automation engineers. You will be mentored by one of our senior researchers, who has significant experience in machine learning for Computer Vision and disease modeling. You will also attend our machine learning team meetings and will be exposed to a diverse set of novel technologies and machine learning concepts that tackle various biological questions.&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;Join us, and help make a difference to patients!&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Working towards a BS, MS, or Ph.D. in an engineering, computer science, mathematics, statistics, life science, chemistry, physics, or a related discipline&lt;/li&gt;
&lt;li&gt;Proficiency in one or more general-purpose programming languages. We primarily use Python&lt;/li&gt;
&lt;li&gt;Demonstrated ability to use and develop cutting edge statistical and machine learning methods inspired by real problems&lt;/li&gt;
&lt;li&gt;Demonstrated ability to write high-quality, production-ready code (readable, well-tested, with well-designed APIs)&lt;/li&gt;
&lt;li&gt;Experience with Machine and Deep Learning frameworks (e.g., scikit-learn, PyTorch, etc.)&lt;/li&gt;
&lt;li&gt;Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions&lt;/li&gt;
&lt;li&gt;Passion for making a difference in the world&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Nice to Have&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Experience with Computer Vision libraries (e.g., OpenCV, scikit-image, etc.)&lt;/li&gt;
&lt;li&gt;Experience in Linux environment, database languages (e.g., SQL, No-SQL) and version control practices and tools such as Git or Mercurial&lt;/li&gt;
&lt;li&gt;Familiarity with the SciPy/PyData ecosystem (numpy, pandas, scipy, dask etc.)&lt;/li&gt;
&lt;li&gt;Familiarity with cloud computing services (AWS or GCP)&lt;/li&gt;
&lt;/ul&gt;
&lt;div&gt;&amp;nbsp;&lt;/div&gt;
&lt;div&gt;&lt;strong&gt;Intern&amp;nbsp;Benefits&lt;/strong&gt;&lt;/div&gt;
&lt;ul&gt;
&lt;li&gt;Excellent medical, dental, and vision coverage; insitro pays 100% of premiums for employees&lt;/li&gt;
&lt;li&gt;Excellent mental health and well-being support&lt;/li&gt;
&lt;li&gt;Access to free onsite baristas and cafe with daily lunch and breakfast&lt;/li&gt;
&lt;li&gt;Access to free onsite fitness center&lt;/li&gt;
&lt;li&gt;Commuter benefits&lt;/li&gt;
&lt;li&gt;Competitive pay&lt;/li&gt;
&lt;li&gt;Flexible work schedule (on site and remote)&lt;/li&gt;
&lt;/ul&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;div class=&quot;section page-centered&quot;&gt;
&lt;p&gt;&lt;strong&gt;About insitro&lt;/strong&gt;&lt;/p&gt;
&lt;/div&gt;
&lt;div class=&quot;section page-centered&quot;&gt;
&lt;div&gt;insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&amp;amp;D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at&amp;nbsp;&lt;a class=&quot;postings-link&quot; href=&quot;http://www.insitro.com/&quot;&gt;www.insitro.com&lt;/a&gt;.&lt;/div&gt;
&lt;/div&gt;&lt;/div&gt;

Data Science & Machine Learning Intern: Core Imaging

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are currently seeking to recruit a talented Postdoctoral Scientist to join our Pathway Biology group to explore mechanisms of lysosomal dysfunction linked to Parkinson’s disease (PD).&amp;nbsp; Reporting to Anastasia Henry, the Postdoctoral Scientist will examine the molecular underpinnings of how variants in PD-linked proteins impact lysosomal function and lipid homeostasis and ultimately contribute to the pathogenesis of PD. The Postdoctoral Scientist will employ a cross-functional approach to work toward the ultimate goal of identifying novel potential targets for the treatment of PD.&lt;/p&gt;
&lt;p&gt;&lt;br&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform research in a dynamic and collaborative environment&lt;/li&gt;
&lt;li&gt;Collaborate with colleagues across diverse functional areas, including human genetics&lt;br&gt;and functional genomics, to achieve research goals&lt;/li&gt;
&lt;li&gt;Make detailed observations, analyze data, interpret results and communicate clearly&lt;/li&gt;
&lt;li&gt;Design and implement assays to probe lysosomal function and identify novel regulators&lt;/li&gt;
&lt;li&gt;Attend conferences, write and publish manuscripts in peer-reviewed journals&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in Cell Biology, Biochemistry, Neuroscience or related fields&lt;/li&gt;
&lt;li&gt;Proficiency in a broad range of biochemical and cellular techniques including&lt;br&gt;mammalian cell culture and transfection, western blotting, and immunofluorescence&lt;/li&gt;
&lt;li&gt;Expertise in live-cell imaging and quantitative image analysis&lt;/li&gt;
&lt;li&gt;Experience in the field of membrane trafficking or lysosomal biology is highly desired&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills&lt;/li&gt;
&lt;li&gt;Creative thinker with a strong sense of responsibility and collaborative spirit&lt;/li&gt;
&lt;li&gt;Priority will be given to candidates with no or short (&amp;lt;1 year) prior postdoctoral&lt;br&gt;experience&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-BR1&lt;/p&gt;

Postdoctoral Scientist, Lysosomal Biology 

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Denali Therapeutics is dedicated to developing breakthrough therapies for patients with neurodegenerative diseases through deep commitment to understanding degeneration biology and rigorously applying the principles of translational medicine. Denali is seeking a motivated Research Scientist to join our Biology Discovery group. This individual will develop and perform &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; cell-based assays to support novel therapeutic target identification and validation. The ideal candidate must be self-driven, organized and able to collaborate with multiple groups to support the lysosomal biology and glia biology teams.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Work under supervision of Denali senior scientists to conduct research in a dynamic, highly-collaborative and fast-paced environment&lt;/li&gt;
&lt;li&gt;Support identification and validation of targets using &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt;&lt;/li&gt;
&lt;li&gt;Maintain detailed records of the experimental procedures and data in accordance with Denali policy&lt;/li&gt;
&lt;li&gt;Communicate experimental designs, protocols, and data to cross-functional teams and collaborators&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;strong&gt;Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;A Bachelors or Masters degree with at least 3 years of pharmaceutical/biotech experience in biology, neuroscience, cell biology, or related field&lt;/li&gt;
&lt;li&gt;Extensive experience in molecular, biochemical, and cellular techniques, including mammalian cell culture and transfection, western blotting, immunohistochemistry, ELISA and qPCR&lt;/li&gt;
&lt;li&gt;Expertise in microscopy and image analysis is preferred&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills and enjoy collaborative environments&lt;/li&gt;
&lt;li&gt;Creative and inquisitive thinker who is eager to explore and learn new skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p class=&quot;p1&quot;&gt;#LI-BR1&lt;/p&gt;

Research Scientist, Discovery Biology

&lt;p&gt;Job Post Goes Here&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;h2&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;About Twist Bioscience&lt;/span&gt;&lt;/h2&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.&lt;/span&gt;&lt;/p&gt;

Staff Data Scientist, DNA Products

&lt;p&gt;&lt;strong&gt;About Freenome&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is a high-growth biotech company on a mission since 2014 to create tools that empower everyone to prevent, detect, and treat their disease.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;To achieve this mission, Freenome is developing next-generation blood tests to detect cancer in its earliest, most treatable stages using our multiomics platform and machine learning techniques. Our first blood test will detect early-stage colorectal cancer and advanced adenomas.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About the Role&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;At Freenome, you will help develop the assay technologies used to analyze patient samples and contribute to our mission of early detection and intervention in human disease. As a Development Scientist, you will provide expertise in next-generation-sequencing (NGS)-based analyses of DNA and RNA. Starting with a prototype assay, you will contribute to developing, optimizing, and validating clinical-grade assays to measure complex, blood-based analytes (e.g., whole-genome sequencing of cfDNA). You will work closely with multiple teams including research team, process engineers, computational science team, and clinical operations to develop and optimize the assays in a regulated, high-throughput environment as well as identify ways to rapidly iterate and improve on existing methods to evaluate technologies that can enhance our end-to-end test performance.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Your contribution:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Apply expert knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA, RNA, protein, and other bioanalyte including genome-wide and targeted approaches&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Develop assays by converting manual prototypes into optimized, high-throughput validated assays&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Identify workflow and protocol improvement by analyzing and developing method data&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with computational biologists and software engineers to build analysis pipelines and to integrate new molecular technologies into analytical workflows.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Collaborate with clinical laboratory members to transition development protocols into production, including automation, validation experiments, and SOP development.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Present data in cross functional teams&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Apply your knowledge of Design Control, Quality Management and Risk Mitigation to product and study design.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Document product development requirements and author study protocols and reports&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Your background, perspective and experience:&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;PhD (or equivalent industry experience) in molecular biology, biochemistry, genetics, chemistry, or a related field&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Experience in molecular diagnostic assay development, preferably in an FDA regulated environment for IVD under design control.&amp;nbsp; LDT/CLIA and CE-IVD experience will also be considered.&amp;nbsp; PMA submission experience desired.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Broad, expert-level knowledge of NGS assays for DNA and RNA, including general nucleic acid biochemistry as well as specific optimizations for different applications, sequencing platforms, and analytes.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Proven track record of establishing new methods for NGS-based measurements of biology (*-seq) that go beyond kitted assays&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Familiarity with programing in a scientific programming language (e.g., Python or R) and perform bioinformatics analyses to enable experimental iteration independent of external support&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Ability to design for automated platforms in plate-based, low-volume formats and/or microfluidics and experience working with automated liquid handlers.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Biological understanding of human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Hands-on proficiency in managing technology transfer requirements, including guard-banding, stability studies, and in-process quality control.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Clear communications skills and ability to work with team members in the same and adjacent disciplines&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;COVID safety:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;As a condition of employment, you agree to know and comply with our COVID-19 vaccination policy requiring all employees who work on-site and/or attend work-related events to be fully vaccinated and to receive a COVID-19 booster once eligible. Company employees working on-site are required to be fully vaccinated for COVID-19 and to receive a COVID-19 booster once eligible, unless a reasonable accommodation is approved or as otherwise required by law. Absent a reasonable accommodation or legal exception, you agree to provide proof of your vaccination status and to be fully vaccinated by your first day on-site, in accordance with our policy.&amp;nbsp; If you are currently eligible for a COVID-19 booster, you also agree to provide proof of having received a booster.&amp;nbsp; If you are not yet eligible for a COVID-19 booster, you must provide proof of receiving a booster within two weeks of becoming eligible.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Funding&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We have raised more than $1.1B from leading investors including Perceptive Advisors, RA Capital Management, Roche Venture Fund, Kaiser Permanente, Novartis and the American Cancer Society’s BrightEdge Ventures.&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Freenomers&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;A ‘Freenomer’ is a mission-driven employee who is fueled by the opportunity to make a positive impact on patients&#x27; lives, who thrives in a culture of respect and cross collaboration, and whose work makes a significant impact on the company and their career.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Freenomers are technical, creative, visionary, grounded, empathetic and passionate. We build teams around divergent expertise, allowing us to solve problems and ascertain opportunities in unique ways. Freenomers are some of the most talented experts in their fields, joining together to advance healthcare, one breakthrough at a time.&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Benefits include but are not limited to:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Competitive compensation&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Pre-IPO equity&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Flexible PTO (exempt) and generous PTO (non-exempt)&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Comprehensive health coverage, including medical, dental, and vision&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Wellness and mental health resources, including Employee Assistance Programs (EAPs), Paid maternity and paternity leave&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;401(k) plan&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;$250.00 new hire stipend to enhance your home office experience&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Plus, a variety of other perks, including pre-tax commuter benefits, two paid volunteer days per year, pet insurance, and additional discounts&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;# # #&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Applicants have rights under Federal Employment Laws.&amp;nbsp;&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/fmla&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Family &amp;amp; Medical Leave Act (FMLA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/ofccp/posters&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Equal Employment Opportunity (EEO)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 300;&quot;&gt;&lt;a href=&quot;https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act&quot;&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Employee Polygraph Protection Act (EPPA)&lt;/span&gt;&lt;/em&gt;&lt;/a&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;&lt;em&gt;Notice to agencies&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;:&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Our in-house Talent Acquisition Team manages all employment opportunities at Freenome.&amp;nbsp; Agencies and independent recruiters must be approved as a vendor by Freenome’s Talent Acquisition team before submitting candidates to any Freenome employee.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;We do not accept unsolicited resumes or biographies from agencies under any circumstances. Any unsolicited resumes sent to Freenome, including those sent to a Freenome email address or directly to Freenome employees, will be considered Freenome property. Freenome will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume. Freenome will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;Please do not contact Freenome employees directly. Compliance with this request will impact our decision to work with you.&amp;nbsp;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;###&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 300;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;#LI-Remote, #LI-Onsite, #LI-Hybrid&lt;/span&gt;&lt;/span&gt;&lt;/em&gt;&lt;/p&gt;

(Senior) Development Scientist - IVD Pre-analytics

&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is continuing to build a leading, innovative Discovery organization that will strongly contribute to the discovery and development of novel therapeutics for neurodegenerative diseases. We are currently seeking excellent candidates to join our Discovery team based at our headquarters in South San Francisco, California.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;The candidate for this senior position will be responsible for leading the production efforts of large molecule biotherapeutics, across the discovery-to-development stages, to support the identification and characterization of novel therapeutics for the treatment of neurodegenerative diseases.&amp;nbsp; Under minimal supervision, the &lt;/span&gt;&lt;strong&gt;Principal Scientist&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; for this position will independently design and implement production and purification strategies for complex engineered antibodies, Fc-fusions and bioconjugated therapeutics.&amp;nbsp; Working with multiple groups across Denali, he/she will generate highly characterized proteins, from the milligram to gram scale, to enable &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vitro &lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;and &lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;in vivo&lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt; studies and to support development efforts.&amp;nbsp; You will be expected to design, perform and oversee experiments, mentor colleagues, analyze and interpret results, coordinate appropriate CRO activities (including both routine and complex protein production), organize and carefully document results, and communicate findings.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We seek candidates with extensive experience in generating antibodies, antibody-drug conjugates (or bioconjugations), and/or engineered Fc-fusions, across the discovery-to-development stages.&amp;nbsp; Close collaboration with protein engineers, pharmacologists, biologists &amp;amp; CMC teams will be essential to success.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Design, implement &amp;amp; optimize purification and production strategies for large molecule biotherapeutics, including engineered antibodies (and other IgG-like molecules), bioconjugations and engineered Fc-fusions&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Purify large molecule therapeutics from cell culture (&lt;/span&gt;&lt;em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;i.e. &lt;/span&gt;&lt;/em&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;CHO/293) by column chromatography using AKTA systems, and design and transition to scalable processes, up to gram quantities&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Lead troubleshooting efforts for protein expression and purification processes&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analyze proteins using standard protein characterization methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Guide the development and implementation of fit-for-purpose analytics that support development&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support hit generation and lead optimization activities for multiple large molecule targets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Assist in identifying lead therapeutic candidate molecules based on purification &amp;amp; analytical workflows&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Think creatively about ways to integrate novel protein modalities with our blood-brain-barrier (BBB)-crossing technologies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Actively contribute to project teams and work effectively across functional teams to help advance programs to development&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Successful candidates will meet most of these criteria:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD in Biochemistry or related scientific discipline with 12+ years in biotech/biopharma industry or M.Sc/B.Sc. with ≥15 years of experience in biotech/biopharma&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive experience in biotherapeutic protein production and biochemistry, as reflected in authorship on peer-reviewed publications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in the generation and development of antibody-drug conjugates and/or other bioconjugated materials&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-depth experience in the purification of challenging and/or engineered proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience working with CROs for the production of routine and complex proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive knowledge and hands-on experience with large molecule protein purification workflows including multiple chromatographic methods (immunoaffinity, IEC, HIC, SEC)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in molecular biology, including construct design&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent oral, presentation and written communication skills are required&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Creative thinker with a strong sense of r&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;esponsibility and a desire to collaborate in an exciting and fast-paced research environment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment.&amp;nbsp; We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;#LI-AS1&lt;/p&gt;

Principal Scientist, Biochemistry (Protein Technologies) 

&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is continuing to build a leading, innovative Discovery organization that will strongly contribute to the discovery and development of novel therapeutics for neurodegenerative diseases. We are currently seeking excellent candidates to join our Discovery team based at our headquarters in South San Francisco, California.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;This role will support Denali’s expanded large molecule biotherapeutics efforts with the goal of identifying novel therapeutics for the treatment of neurodegenerative diseases. Accordingly, we seek candidates with experience in generating challenging or unprecedented proteins and protein complexes. The successful candidate will be responsible for leading the biochemical characterization of large molecule biotherapeutics including guiding the development of robust and scalable purification processes and fit-for-purpose analytics. Close collaboration with protein engineers, pharmacologists, biologists &amp;amp; CMC teams will be essential to success.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Design, implement &amp;amp; optimize purification approaches for enzymes, enzyme-Fc fusions and difficult-to-express protein complexes&amp;nbsp;&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Purify enzymes from cell culture (CHO/293) by column chromatography (using AKTA systems)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Develop and troubleshoot protein purification processes using chromatographic methods (AKTA system)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Analyze proteins using standard protein characterization methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Lead troubleshooting efforts for protein expression and purification processes&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Support hit generation and lead optimization activities for multiple large molecule targets&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Assist in identifying lead therapeutic candidate molecules based on purification &amp;amp; analytical workflows&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Think creatively about ways to integrate novel protein modalities with our BBB-crossing technologies&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Actively contribute to project teams and work effectively across functional teams to help advance programs&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Successful candidates will meet most of these criteria:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;PhD in Biochemistry or related scientific discipline with 3+ years in biotech/biopharma industry or M.Sc/B.Sc. with ≥6 years of experience in biotech/biopharma&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in protein biochemistry and enzymology, as reflected in authorship on peer-reviewed publications&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;In-depth experience in the purification of challenging proteins, complexes and fusions proteins&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Extensive knowledge and hands-on experience with large molecule protein purification workflows including multiple chromatographic methods (immunoaffinity, IEC, HIC, SEC)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experience in molecular biology, including plasmid design&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Excellent oral, presentation and written communication skills are required&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Creative thinker with a strong sense of r&lt;/span&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;esponsibility and a desire to collaborate in an exciting and fast-paced research environment&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment.&amp;nbsp; We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;#LI-AS1&lt;/p&gt;

Senior Scientist, Biochemistry (Protein Technologies) 

&lt;div class=&quot;content-intro&quot;&gt;&lt;p&gt;EVERY™, based in South San Francisco, is a leading VC-backed food tech ingredient company using precision fermentation to create animal proteins without the animal for the global food and beverage industry. Originally founded as Clara Foods in 2014, EVERY™ rebranded in 2021 to better convey its vision to bring animal-free proteins to everyone, everywhere. EVERY™ is a team of passionate change makers who are reimagining the factory farm model with a kinder, more sustainable alternative. Leveraging precision fermentation to produce hyper-functional and one-to-one replacement proteins from microorganisms, EVERY™ is on a mission to decouple the world’s proteins from the animals that make them.&lt;/p&gt;
&lt;p&gt;We are a passionate, determined, (and fun!) team with a vital objective, and we&#x27;re on the lookout for like-minded people to join our mission. Sound like you?&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&lt;span style=&quot;text-decoration: underline;&quot;&gt;&lt;strong&gt;Data Scientist Intern&lt;/strong&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Reports to&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: Director of Data Science &amp;amp; Technologies&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;FLSA Status&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: Non-exempt&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Location&lt;/strong&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;: South San Francisco (Fully remote until further notice)&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;About You&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;You are excited to work with others in applying machine learning, statistics, data visualization, and software engineering to solve complex problems in biology, food science, operations, and sustainability. You are looking forward to participating in the full journey of your work from initial exploration with internal users to integration in a production system, conducting experiments and growing infrastructure along the way. You may or may not be fluent in all of these different areas but are eager to build your knowledge broadly while working with many other parts of the company.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Like others on the team, you will shepard your high impact work from conception to release:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Co-designing data science solutions with other teams and partners.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Experimenting in complex problems and storytelling in highly dimensional datasets, often using machine learning or data visualization.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Participating in creating conduits for data that unite different teams together.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Collaborating on software-based tools around your work.&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Skills and Requirements&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;We are building a team of diverse skills and backgrounds so encourage folks to apply even if they don’t have all of the following desired skills but want to work with many different tools and technologies:&lt;/span&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Python programming (flask, fastapi, or django a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Data visualization (Tableau, d3, Processing, or p5.js a plus) and / or machine learning-based modeling (experience in scikit and tensorflow a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Working with SQL databases (postgres a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Statistical understanding (experience in scipy or statsmodels a plus)&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Prior work or desire to grow in food, bioinformatics, and operations research.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Prior experience with user / human-centered design a plus but not required.&lt;/span&gt;&lt;/li&gt;
&lt;li style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Unit testing and CI/CD a plus&lt;/span&gt;&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;Note: though most employees are currently working from home, you will be expected to be available during regular business hours (9am to 5pm Pacific Time) and, periodically, during pre-scheduled times outside regular business hours.&lt;/span&gt;&lt;/p&gt;&lt;div class=&quot;content-conclusion&quot;&gt;&lt;p&gt;&lt;strong&gt;What EVERY™ can Offer for Full-Time Positions:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Generous benefits package; 100% medical, dental, and vision employee coverage, 401k matching, and stock&lt;/li&gt;
&lt;li&gt;Optional benefits; FSA, HSA, Commuter, Pet Care, and additional life insurance&lt;/li&gt;
&lt;li&gt;Flexible PTO and 14 paid company holidays per year&lt;/li&gt;
&lt;li&gt;Free parking, unlimited gym access, lounge, mini-golf patio, yoga and fitness classes onsite&lt;/li&gt;
&lt;li&gt;Unlimited supply of sparkling water, granola bars, snacks, local coffee and tea&lt;/li&gt;
&lt;li&gt;Weekly virtual happy hours &amp;amp; lunches&lt;/li&gt;
&lt;li&gt;Monthly all-hands meetings and 1:1 with CEO and leadership&lt;/li&gt;
&lt;li&gt;Close to South San Francisco BART and CalTrain stations, including free shuttle service&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;span style=&quot;font-weight: 400;&quot;&gt;EVERY™ is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Legal authorization to work in the U.S. is required.&amp;nbsp; We are not able to sponsor individuals for employment visas for this job.&amp;nbsp;&lt;/em&gt;&lt;em&gt;In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.&lt;/em&gt;&lt;/p&gt;&lt;/div&gt;

Data Scientist Intern

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;We are seeking a highly motivated Associate Scientist to join our Antibody Discovery and Protein Engineering group and contribute to the discovery and development of novel biotherapeutics for the treatment of neurodegenerative diseases. You will support the discovery, engineering, and characterization of therapeutic lead antibodies to maximize their therapeutic potential.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;&lt;strong&gt;&amp;nbsp;&lt;/strong&gt;Conduct high-throughput SPR binding screens to support antibody discovery, engineering, and development&lt;/li&gt;
&lt;li&gt;Develop and optimize biochemical and biophysical assays to interrogate protein: protein interactions, including SPR (Biacore), BLI (Octet), and other related techniques&lt;/li&gt;
&lt;li&gt;Communicate results within the Biosensors group and to cross-functional project teams&lt;/li&gt;
&lt;li&gt;Conduct data analysis and maintain compliance to good record keeping (ELN)&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Master’s degree and 1+ year bioengineering, biochemistry, biophysics, or related discipline and industry experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Bachelor’s degree and 3+ years bioengineering, biochemistry, biophysics, or related discipline and industry experience&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience with biochemistry techniques including protein quantitation, protein purification, and/or biophysical/biochemical assays&lt;/li&gt;
&lt;li&gt;General understanding of protein and antibody biophysical characterization methods&lt;/li&gt;
&lt;li&gt;Hands-on experience with Biacore T200, Biacore 8000, Octet Red, Kinexa, and/or microITC instruments&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;

Associate Scientist,Biophysical Characterization

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position Description&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The successful candidate will join a multi-disciplinary science team with a focus on developing high throughput technology to develop novel strategies to characterize protein-protein interactions. The ideal candidate must be highly innovative, motivated, detail-oriented, work autonomously with a variety of experimental techniques, and be comfortable presenting results to cross-functional teams.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position requirements&lt;/strong&gt;:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Ph.D. in molecular biology, biochemistry, or related discipline plus 0-4 years postdoc experience or equivalent experience working in biopharma/biotech sectors&lt;/li&gt;
&lt;li&gt;Proficient with various protein display systems such as yeast, bacteria, phage and mRNA display. Skilled in library creation, selection, and enrichment analysis.&lt;/li&gt;
&lt;li&gt;Experience with high-throughput automated protein (especially antibody) expression and purification&lt;/li&gt;
&lt;li&gt;Experience with antibody characterization and engineering&lt;/li&gt;
&lt;li&gt;Hands-on experience with investigating protein-protein interactions, ability to generate biochemical/biophysical data with SPR, Octet, ITC, FRET assays&lt;/li&gt;
&lt;li&gt;Accountable, meticulous with attention to detail, and able to multitask&lt;/li&gt;
&lt;li&gt;Strong teamwork and proactive communication skills&lt;/li&gt;
&lt;li&gt;Self-motivated and able to work independently in a cross-functional team environment&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Experience with the following is a bonus:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Experience using evolutionary approaches to optimize protein function&lt;/li&gt;
&lt;li&gt;Background with structural biology approaches such as cryo-EM, X-ray crystallography, SAXS, HDX-MS, etc.&lt;/li&gt;
&lt;li&gt;Basic understanding of machine learning for structure prediction.&lt;/li&gt;
&lt;/ul&gt;

Scientist, Biochemistry

&lt;p&gt;Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.&lt;/p&gt;
&lt;p&gt;We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;The Opportunity&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;In anticipation of the Company’s growth plans, Denali Therapeutics is seeking a Scientist focusing on drug discovery research and mechanistic biology related to neurodegenerative diseases. Reporting to a Senior Director and Staff Scientist, the Scientist will perform translational research, with a focus on developing and validating biochemical and cell-based assays to explore mechanisms of neurodegeneration and support therapeutic development.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Perform research in a dynamic and collaborative environment&lt;/li&gt;
&lt;li&gt;Design and implement experiments to investigate disease mechanisms and support drug candidate selection&amp;nbsp;&amp;nbsp;&lt;/li&gt;
&lt;li&gt;Evaluate therapeutic candidates using biochemical assays, cell-based assays, and in vivo studies&lt;/li&gt;
&lt;li&gt;Make detailed scientific observations, analyze data, interpret, and present results&lt;/li&gt;
&lt;li&gt;Collaborate with colleagues in Biology Discovery, Medicinal Chemistry, Protein Sciences, Pharmacology, DMPK, Project Management, CMC, Toxicology, Early Development and Clinical Sciences to develop innovative research and develop novel drugs&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Basic Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;PhD in Biochemistry, Cell Biology or Neurobiology&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Master’s degree and 3+ years related scientific experience&lt;/p&gt;
&lt;p&gt;OR&lt;/p&gt;
&lt;p&gt;Bachelor’s degree and 6+ years related scientific experience&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Preferred Qualifications&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Postdoc or industry experience in cell and/or neuronal cell biology&lt;/li&gt;
&lt;li&gt;Proficiency in a broad range of biochemical, molecular and cellular techniques including: Western blotting, qPCR, transfection, RNA interference, immunofluorescence and/or live imaging techniques, immunohistochemistry, and quantitative image analysis&lt;/li&gt;
&lt;li&gt;Expertise in the culture of mammalian cell lines, primary cells, and/or iPSC-derived CNS cells&lt;/li&gt;
&lt;li&gt;Experience in the field of membrane trafficking, membrane biology or lipid metabolism/transport&lt;/li&gt;
&lt;li&gt;Highly organized with excellent analytical and critical thinking skills&lt;/li&gt;
&lt;li&gt;Strong oral/written communication skills&lt;/li&gt;
&lt;li&gt;Creative and inquisitive thinker who is eager to explore and learn new skills&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;
&lt;p&gt;#LI-GA1&lt;/p&gt;

Scientist, Biology Discovery

&lt;p&gt;&lt;strong&gt;Who we are:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Position description:&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Calico is seeking a Senior Data Scientist to join our efforts in advancing novel therapies from target discovery to clinical development.&lt;/p&gt;
&lt;p&gt;Observations gleaned from the expansive high-dimensional phenotyping efforts of large human cohorts will increasingly advance our understanding of human aging and disease. Human genetics serves a critical role in linking observational phenotypes to their genetic roots but to act on such findings we often want a better understanding of the mechanism underlying a gene’s modulation of a phenotype of interest. Having such knowledge provides both a way to triage genetic associations that impinge on common pathways, but also could lead to other drug targets where natural variation may be highly constrained. To help fill this gap, an ideal candidate in this role will collaborate with our human genetics, translational and systems biology teams to develop and apply a systems genetics strategy for target discovery. This will involve representing genetic associations based on curated mechanistic pathways and exploring both experimental and statistical ways of testing how genetic perturbations are mechanistically transmitted.&lt;/p&gt;
&lt;p&gt;As a member of the Calico’s Computing team, you will work closely with a cross-functional group of computational biologists, machine learning engineers, data scientists, translational project leads, scientists, and biostatisticians to advance Calico’s pipeline. This role offers a unique opportunity to innovate at the leading edge of data science and quantitative systems pharmacology.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Responsibilities: &lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Lead the integration of our human genetics and systems biology platforms&lt;/li&gt;
&lt;li&gt;Plan, prioritize, and execute on high-value systems genetics projects aimed to support both target identification and indication selection&lt;/li&gt;
&lt;li&gt;Establish a process for testing genetic variants with experimental perturbations in cellular systems&lt;/li&gt;
&lt;li&gt;Communicate clearly and effectively in verbal, visual, and written form to stakeholders with varying levels of technical knowledge&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;&lt;strong&gt;Position requirements:&lt;/strong&gt;&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;PhD. /MS and four years of work experience in a quantitative field such as Computer Science, Bioinformatics, Computational Biology, Statistics, Biological Sciences, Genomics, or equivalent preparation&lt;/li&gt;
&lt;li&gt;Experience in human genetics including analysis of rare and common variation, variant prioritization, analysis of multivariate phenotypes (e.g., colocalization) and causal inference&lt;/li&gt;
&lt;li&gt;Familiarity with modeling mechanistic pathways using molecular data&lt;/li&gt;
&lt;li&gt;Fundamental understanding of statistics and machine learning&lt;/li&gt;
&lt;li&gt;Fluency with Python (pandas, numpy, jupyter) and/or R (tidyverse)&lt;/li&gt;
&lt;li&gt;Track record of effective cross-functional collaboration&lt;/li&gt;
&lt;/ul&gt;

Data Scientist Jobs in South San-francisco